RIOK1

 

Full name: RIO kinase 1 Alias Symbol: AD034|FLJ30006|bA288G3.1|RRP10
Type: protein-coding gene Cytoband: 6p24.3
Entrez ID: 83732 HGNC ID: HGNC:18656 Ensembl Gene: ENSG00000124784 OMIM ID: 617753
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RIOK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RIOK1 83732 224450_s_at 1.2435 0.0124
GSE26886 RIOK1 83732 224450_s_at 1.7743 0.0000
GSE45670 RIOK1 83732 224450_s_at 0.6124 0.0011
GSE53622 RIOK1 83732 8104 0.5612 0.0000
GSE53624 RIOK1 83732 8104 0.6669 0.0000
GSE63941 RIOK1 83732 224450_s_at 0.3473 0.3682
GSE77861 RIOK1 83732 224450_s_at 0.9935 0.0004
GSE97050 RIOK1 83732 A_24_P8088 0.6602 0.1267
SRP007169 RIOK1 83732 RNAseq 1.9815 0.0009
SRP008496 RIOK1 83732 RNAseq 1.7869 0.0000
SRP064894 RIOK1 83732 RNAseq 0.6310 0.0058
SRP133303 RIOK1 83732 RNAseq 0.5824 0.0013
SRP159526 RIOK1 83732 RNAseq 0.8428 0.0012
SRP193095 RIOK1 83732 RNAseq 0.4052 0.0020
SRP219564 RIOK1 83732 RNAseq 0.1689 0.6348
TCGA RIOK1 83732 RNAseq 0.2414 0.0001

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RIOK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RIOK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RIOK1 83732 4 5 21
GSE20123 RIOK1 83732 4 5 21
GSE43470 RIOK1 83732 8 2 33
GSE46452 RIOK1 83732 1 10 48
GSE47630 RIOK1 83732 7 8 25
GSE54993 RIOK1 83732 1 1 68
GSE54994 RIOK1 83732 10 3 40
GSE60625 RIOK1 83732 0 1 10
GSE74703 RIOK1 83732 7 2 27
GSE74704 RIOK1 83732 2 2 16
TCGA RIOK1 83732 15 29 52

Total number of gains: 59; Total number of losses: 68; Total Number of normals: 361.  

 

Somatic mutations of RIOK1:

 

Generating mutation plots.

 

Highly correlated genes for RIOK1:

 

Showing top 20/1883 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RIOK1AURKAIP10.842253303
RIOK1C1orf350.819779303
RIOK1SFR10.819245303
RIOK1NCBP20.814215404
RIOK1CCT6A0.807189303
RIOK1LRRC580.804543606
RIOK1MACF10.800345303
RIOK1CDK180.80012303
RIOK1ZNF5840.774839303
RIOK1BRAP0.772441303
RIOK1CLCN70.772167403
RIOK1SENP10.768044303
RIOK1U2SURP0.767972605
RIOK1SPIRE10.767178303
RIOK1MCM3AP0.766319303
RIOK1STX160.765571303
RIOK1SP1000.764164303
RIOK1ITM2C0.763321303
RIOK1SRRT0.762044606
RIOK1PPP1R16A0.762023303

For details and further investigation, click here