| Full name: laminin subunit gamma 3 | Alias Symbol: DKFZp434E202 | ||
| Type: protein-coding gene | Cytoband: 9q34.12 | ||
| Entrez ID: 10319 | HGNC ID: HGNC:6494 | Ensembl Gene: ENSG00000050555 | OMIM ID: 604349 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
LAMC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMC3 | 10319 | 219407_s_at | -0.0181 | 0.9819 | |
| GSE20347 | LAMC3 | 10319 | 219407_s_at | -0.2916 | 0.0030 | |
| GSE23400 | LAMC3 | 10319 | 219407_s_at | -0.2412 | 0.0000 | |
| GSE26886 | LAMC3 | 10319 | 219407_s_at | -0.0267 | 0.9158 | |
| GSE29001 | LAMC3 | 10319 | 219407_s_at | -0.2290 | 0.3208 | |
| GSE38129 | LAMC3 | 10319 | 219407_s_at | -0.1281 | 0.2570 | |
| GSE45670 | LAMC3 | 10319 | 219407_s_at | 0.0401 | 0.8323 | |
| GSE53622 | LAMC3 | 10319 | 22470 | -0.1538 | 0.1235 | |
| GSE53624 | LAMC3 | 10319 | 22470 | 0.1506 | 0.0790 | |
| GSE63941 | LAMC3 | 10319 | 219407_s_at | 0.5545 | 0.0623 | |
| GSE77861 | LAMC3 | 10319 | 219407_s_at | -0.0843 | 0.6150 | |
| GSE97050 | LAMC3 | 10319 | A_33_P3277532 | -0.2142 | 0.6076 | |
| SRP064894 | LAMC3 | 10319 | RNAseq | 0.0736 | 0.8474 | |
| SRP133303 | LAMC3 | 10319 | RNAseq | -0.1129 | 0.6910 | |
| SRP159526 | LAMC3 | 10319 | RNAseq | 1.4731 | 0.0587 | |
| SRP193095 | LAMC3 | 10319 | RNAseq | 1.1243 | 0.0000 | |
| SRP219564 | LAMC3 | 10319 | RNAseq | -0.1585 | 0.8654 | |
| TCGA | LAMC3 | 10319 | RNAseq | 0.5836 | 0.0109 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LAMC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMC3 | 10319 | 6 | 9 | 15 | |
| GSE20123 | LAMC3 | 10319 | 6 | 9 | 15 | |
| GSE43470 | LAMC3 | 10319 | 5 | 7 | 31 | |
| GSE46452 | LAMC3 | 10319 | 6 | 13 | 40 | |
| GSE47630 | LAMC3 | 10319 | 3 | 16 | 21 | |
| GSE54993 | LAMC3 | 10319 | 3 | 3 | 64 | |
| GSE54994 | LAMC3 | 10319 | 12 | 9 | 32 | |
| GSE60625 | LAMC3 | 10319 | 0 | 0 | 11 | |
| GSE74703 | LAMC3 | 10319 | 5 | 5 | 26 | |
| GSE74704 | LAMC3 | 10319 | 3 | 7 | 10 | |
| TCGA | LAMC3 | 10319 | 27 | 26 | 43 |
Total number of gains: 76; Total number of losses: 104; Total Number of normals: 308.
Somatic mutations of LAMC3:
Generating mutation plots.
Highly correlated genes for LAMC3:
Showing top 20/610 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMC3 | RHAG | 0.72382 | 3 | 0 | 3 |
| LAMC3 | FAM107A | 0.715817 | 3 | 0 | 3 |
| LAMC3 | SIX5 | 0.694764 | 3 | 0 | 3 |
| LAMC3 | TSPAN7 | 0.69391 | 3 | 0 | 3 |
| LAMC3 | VWA7 | 0.692399 | 5 | 0 | 5 |
| LAMC3 | INO80D | 0.676231 | 5 | 0 | 4 |
| LAMC3 | G6PC2 | 0.676128 | 3 | 0 | 3 |
| LAMC3 | CLEC4E | 0.673873 | 4 | 0 | 4 |
| LAMC3 | ZNF771 | 0.665528 | 4 | 0 | 4 |
| LAMC3 | MYH7 | 0.665381 | 3 | 0 | 3 |
| LAMC3 | SLC6A6 | 0.663383 | 3 | 0 | 3 |
| LAMC3 | GNG7 | 0.662565 | 3 | 0 | 3 |
| LAMC3 | PDYN | 0.66185 | 5 | 0 | 4 |
| LAMC3 | ADAMTS10 | 0.661021 | 5 | 0 | 5 |
| LAMC3 | PROP1 | 0.660026 | 4 | 0 | 4 |
| LAMC3 | ZNF263 | 0.659817 | 3 | 0 | 3 |
| LAMC3 | INSRR | 0.659644 | 5 | 0 | 4 |
| LAMC3 | UMOD | 0.658413 | 4 | 0 | 4 |
| LAMC3 | ZNF546 | 0.657776 | 3 | 0 | 3 |
| LAMC3 | RASGRP2 | 0.656989 | 3 | 0 | 3 |
For details and further investigation, click here
