| Full name: ADAM metallopeptidase domain 22 | Alias Symbol: MDC2 | ||
| Type: protein-coding gene | Cytoband: 7q21.12 | ||
| Entrez ID: 53616 | HGNC ID: HGNC:201 | Ensembl Gene: ENSG00000008277 | OMIM ID: 603709 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM22 | 53616 | 208227_x_at | 0.1775 | 0.3965 | |
| GSE20347 | ADAM22 | 53616 | 208227_x_at | 0.1471 | 0.2611 | |
| GSE23400 | ADAM22 | 53616 | 208227_x_at | -0.1284 | 0.0015 | |
| GSE26886 | ADAM22 | 53616 | 208226_x_at | -0.0137 | 0.9174 | |
| GSE29001 | ADAM22 | 53616 | 208227_x_at | -0.0832 | 0.6868 | |
| GSE38129 | ADAM22 | 53616 | 208227_x_at | -0.0358 | 0.7311 | |
| GSE45670 | ADAM22 | 53616 | 208227_x_at | 0.1002 | 0.2459 | |
| GSE53622 | ADAM22 | 53616 | 63657 | -0.3508 | 0.2094 | |
| GSE53624 | ADAM22 | 53616 | 28984 | -1.3002 | 0.0000 | |
| GSE63941 | ADAM22 | 53616 | 208227_x_at | 0.7026 | 0.0654 | |
| GSE77861 | ADAM22 | 53616 | 208226_x_at | -0.0373 | 0.6229 | |
| GSE97050 | ADAM22 | 53616 | A_24_P243741 | 0.0342 | 0.8915 | |
| SRP007169 | ADAM22 | 53616 | RNAseq | 2.6178 | 0.0073 | |
| SRP064894 | ADAM22 | 53616 | RNAseq | -0.1743 | 0.4941 | |
| SRP133303 | ADAM22 | 53616 | RNAseq | 0.1561 | 0.7454 | |
| SRP159526 | ADAM22 | 53616 | RNAseq | -0.3507 | 0.5493 | |
| SRP193095 | ADAM22 | 53616 | RNAseq | 0.2443 | 0.4225 | |
| SRP219564 | ADAM22 | 53616 | RNAseq | -0.2508 | 0.6518 | |
| TCGA | ADAM22 | 53616 | RNAseq | -0.2294 | 0.6119 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ADAM22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM22 | 53616 | 13 | 1 | 16 | |
| GSE20123 | ADAM22 | 53616 | 13 | 1 | 16 | |
| GSE43470 | ADAM22 | 53616 | 5 | 1 | 37 | |
| GSE46452 | ADAM22 | 53616 | 12 | 0 | 47 | |
| GSE47630 | ADAM22 | 53616 | 8 | 2 | 30 | |
| GSE54993 | ADAM22 | 53616 | 2 | 7 | 61 | |
| GSE54994 | ADAM22 | 53616 | 17 | 2 | 34 | |
| GSE60625 | ADAM22 | 53616 | 0 | 0 | 11 | |
| GSE74703 | ADAM22 | 53616 | 4 | 1 | 31 | |
| GSE74704 | ADAM22 | 53616 | 9 | 1 | 10 | |
| TCGA | ADAM22 | 53616 | 54 | 5 | 37 |
Total number of gains: 137; Total number of losses: 21; Total Number of normals: 330.
Somatic mutations of ADAM22:
Generating mutation plots.
Highly correlated genes for ADAM22:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM22 | SAG | 0.791331 | 5 | 0 | 5 |
| ADAM22 | MIER2 | 0.7796 | 3 | 0 | 3 |
| ADAM22 | NTNG1 | 0.767325 | 4 | 0 | 4 |
| ADAM22 | ITGB3 | 0.76147 | 4 | 0 | 4 |
| ADAM22 | CLDN18 | 0.757002 | 3 | 0 | 3 |
| ADAM22 | NEUROD2 | 0.75536 | 4 | 0 | 4 |
| ADAM22 | UBE2O | 0.754709 | 3 | 0 | 3 |
| ADAM22 | KCNV1 | 0.750124 | 3 | 0 | 3 |
| ADAM22 | MTAP | 0.737283 | 5 | 0 | 5 |
| ADAM22 | CCDC7 | 0.734674 | 5 | 0 | 5 |
| ADAM22 | NEU3 | 0.730908 | 5 | 0 | 5 |
| ADAM22 | SLC5A7 | 0.725556 | 4 | 0 | 4 |
| ADAM22 | ZMIZ2 | 0.725277 | 3 | 0 | 3 |
| ADAM22 | HAND1 | 0.717645 | 5 | 0 | 5 |
| ADAM22 | UBE2D4 | 0.712148 | 5 | 0 | 4 |
| ADAM22 | CLASRP | 0.705803 | 3 | 0 | 3 |
| ADAM22 | SSTR4 | 0.704852 | 3 | 0 | 3 |
| ADAM22 | ODF1 | 0.703835 | 4 | 0 | 4 |
| ADAM22 | ATG10 | 0.703063 | 7 | 0 | 6 |
| ADAM22 | CRHR2 | 0.696076 | 4 | 0 | 4 |
For details and further investigation, click here
