| Full name: cysteinyl leukotriene receptor 2 | Alias Symbol: CysLT(2)|CYSLT2R | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 57105 | HGNC ID: HGNC:18274 | Ensembl Gene: ENSG00000152207 | OMIM ID: 605666 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CYSLTR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of CYSLTR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYSLTR2 | 57105 | 220813_at | 0.0473 | 0.8746 | |
| GSE20347 | CYSLTR2 | 57105 | 220813_at | 0.1328 | 0.1209 | |
| GSE23400 | CYSLTR2 | 57105 | 220813_at | -0.0391 | 0.2036 | |
| GSE26886 | CYSLTR2 | 57105 | 220813_at | -0.0631 | 0.5836 | |
| GSE29001 | CYSLTR2 | 57105 | 220813_at | -0.0192 | 0.9110 | |
| GSE38129 | CYSLTR2 | 57105 | 220813_at | -0.0700 | 0.3973 | |
| GSE45670 | CYSLTR2 | 57105 | 220813_at | 0.1013 | 0.2424 | |
| GSE53622 | CYSLTR2 | 57105 | 49516 | -0.1992 | 0.2039 | |
| GSE53624 | CYSLTR2 | 57105 | 49516 | -0.1927 | 0.2409 | |
| GSE63941 | CYSLTR2 | 57105 | 220813_at | 0.2103 | 0.1875 | |
| GSE77861 | CYSLTR2 | 57105 | 220813_at | -0.0991 | 0.2456 | |
| GSE97050 | CYSLTR2 | 57105 | A_23_P319466 | 0.2900 | 0.3497 | |
| SRP007169 | CYSLTR2 | 57105 | RNAseq | 1.4898 | 0.1456 | |
| SRP064894 | CYSLTR2 | 57105 | RNAseq | 0.8166 | 0.0236 | |
| SRP133303 | CYSLTR2 | 57105 | RNAseq | 0.2521 | 0.2397 | |
| SRP159526 | CYSLTR2 | 57105 | RNAseq | -0.4710 | 0.5389 | |
| SRP193095 | CYSLTR2 | 57105 | RNAseq | -0.2227 | 0.0330 | |
| SRP219564 | CYSLTR2 | 57105 | RNAseq | 0.1099 | 0.8392 | |
| TCGA | CYSLTR2 | 57105 | RNAseq | 0.0919 | 0.7688 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYSLTR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYSLTR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYSLTR2 | 57105 | 1 | 13 | 16 | |
| GSE20123 | CYSLTR2 | 57105 | 1 | 12 | 17 | |
| GSE43470 | CYSLTR2 | 57105 | 3 | 13 | 27 | |
| GSE46452 | CYSLTR2 | 57105 | 0 | 32 | 27 | |
| GSE47630 | CYSLTR2 | 57105 | 2 | 27 | 11 | |
| GSE54993 | CYSLTR2 | 57105 | 12 | 2 | 56 | |
| GSE54994 | CYSLTR2 | 57105 | 1 | 17 | 35 | |
| GSE60625 | CYSLTR2 | 57105 | 0 | 3 | 8 | |
| GSE74703 | CYSLTR2 | 57105 | 3 | 10 | 23 | |
| GSE74704 | CYSLTR2 | 57105 | 0 | 9 | 11 | |
| TCGA | CYSLTR2 | 57105 | 7 | 38 | 51 |
Total number of gains: 30; Total number of losses: 176; Total Number of normals: 282.
Somatic mutations of CYSLTR2:
Generating mutation plots.
Highly correlated genes for CYSLTR2:
Showing top 20/826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYSLTR2 | TMEM214 | 0.769405 | 3 | 0 | 3 |
| CYSLTR2 | LMAN1 | 0.769307 | 3 | 0 | 3 |
| CYSLTR2 | RGS18 | 0.751431 | 4 | 0 | 4 |
| CYSLTR2 | GAD2 | 0.749387 | 4 | 0 | 4 |
| CYSLTR2 | SLC6A12 | 0.744775 | 4 | 0 | 4 |
| CYSLTR2 | ERCC4 | 0.74071 | 5 | 0 | 5 |
| CYSLTR2 | AOAH | 0.737136 | 4 | 0 | 4 |
| CYSLTR2 | MTAP | 0.73523 | 5 | 0 | 5 |
| CYSLTR2 | GIMAP5 | 0.728918 | 3 | 0 | 3 |
| CYSLTR2 | STAT2 | 0.723241 | 4 | 0 | 4 |
| CYSLTR2 | OPHN1 | 0.720554 | 5 | 0 | 5 |
| CYSLTR2 | CD163L1 | 0.719763 | 4 | 0 | 4 |
| CYSLTR2 | NEUROD6 | 0.718255 | 4 | 0 | 4 |
| CYSLTR2 | LGI2 | 0.716755 | 4 | 0 | 3 |
| CYSLTR2 | CHST5 | 0.716096 | 5 | 0 | 4 |
| CYSLTR2 | GP1BA | 0.714427 | 4 | 0 | 4 |
| CYSLTR2 | SNAI3 | 0.71442 | 3 | 0 | 3 |
| CYSLTR2 | TNFSF8 | 0.713172 | 6 | 0 | 6 |
| CYSLTR2 | PLA2G2A | 0.70728 | 4 | 0 | 3 |
| CYSLTR2 | CXCR5 | 0.702132 | 5 | 0 | 4 |
For details and further investigation, click here
