| Full name: chimerin 1 | Alias Symbol: RhoGAP2|ARHGAP2|n-chimerin | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 1123 | HGNC ID: HGNC:1943 | Ensembl Gene: ENSG00000128656 | OMIM ID: 118423 |
| Drug and gene relationship at DGIdb | |||
Expression of CHN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHN1 | 1123 | 212624_s_at | 0.5902 | 0.5947 | |
| GSE20347 | CHN1 | 1123 | 212624_s_at | 0.7424 | 0.0001 | |
| GSE23400 | CHN1 | 1123 | 212624_s_at | 0.5588 | 0.0000 | |
| GSE26886 | CHN1 | 1123 | 212624_s_at | 1.1177 | 0.0066 | |
| GSE29001 | CHN1 | 1123 | 212624_s_at | 0.9855 | 0.0035 | |
| GSE38129 | CHN1 | 1123 | 212624_s_at | 0.6225 | 0.0173 | |
| GSE45670 | CHN1 | 1123 | 212624_s_at | 0.0384 | 0.9474 | |
| GSE53622 | CHN1 | 1123 | 2194 | 1.6127 | 0.0000 | |
| GSE53624 | CHN1 | 1123 | 2194 | 1.7091 | 0.0000 | |
| GSE63941 | CHN1 | 1123 | 212624_s_at | -2.9620 | 0.0035 | |
| GSE77861 | CHN1 | 1123 | 212624_s_at | 0.7216 | 0.0158 | |
| GSE97050 | CHN1 | 1123 | A_33_P3325723 | 0.5162 | 0.2151 | |
| SRP007169 | CHN1 | 1123 | RNAseq | 2.8327 | 0.0000 | |
| SRP008496 | CHN1 | 1123 | RNAseq | 3.0629 | 0.0000 | |
| SRP064894 | CHN1 | 1123 | RNAseq | 1.6786 | 0.0000 | |
| SRP133303 | CHN1 | 1123 | RNAseq | 1.7129 | 0.0000 | |
| SRP159526 | CHN1 | 1123 | RNAseq | 1.0398 | 0.0020 | |
| SRP193095 | CHN1 | 1123 | RNAseq | 2.9568 | 0.0000 | |
| SRP219564 | CHN1 | 1123 | RNAseq | 0.5802 | 0.4534 | |
| TCGA | CHN1 | 1123 | RNAseq | 0.4086 | 0.0011 |
Upregulated datasets: 9; Downregulated datasets: 1.
Survival by CHN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHN1 | 1123 | 9 | 0 | 21 | |
| GSE20123 | CHN1 | 1123 | 9 | 0 | 21 | |
| GSE43470 | CHN1 | 1123 | 6 | 1 | 36 | |
| GSE46452 | CHN1 | 1123 | 1 | 4 | 54 | |
| GSE47630 | CHN1 | 1123 | 5 | 3 | 32 | |
| GSE54993 | CHN1 | 1123 | 0 | 5 | 65 | |
| GSE54994 | CHN1 | 1123 | 12 | 3 | 38 | |
| GSE60625 | CHN1 | 1123 | 0 | 3 | 8 | |
| GSE74703 | CHN1 | 1123 | 5 | 1 | 30 | |
| GSE74704 | CHN1 | 1123 | 5 | 0 | 15 | |
| TCGA | CHN1 | 1123 | 29 | 5 | 62 |
Total number of gains: 81; Total number of losses: 25; Total Number of normals: 382.
Somatic mutations of CHN1:
Generating mutation plots.
Highly correlated genes for CHN1:
Showing top 20/1518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHN1 | RFTN2 | 0.812964 | 3 | 0 | 3 |
| CHN1 | MMD | 0.812165 | 13 | 0 | 13 |
| CHN1 | FCGR3A | 0.804201 | 3 | 0 | 3 |
| CHN1 | COL6A3 | 0.803907 | 13 | 0 | 13 |
| CHN1 | VCAN | 0.803363 | 13 | 0 | 13 |
| CHN1 | FADS1 | 0.802289 | 3 | 0 | 3 |
| CHN1 | SPARC | 0.798464 | 13 | 0 | 13 |
| CHN1 | C11orf96 | 0.794479 | 4 | 0 | 4 |
| CHN1 | CTSK | 0.792884 | 13 | 0 | 13 |
| CHN1 | FSTL1 | 0.790823 | 13 | 0 | 13 |
| CHN1 | COL6A1 | 0.789546 | 13 | 0 | 13 |
| CHN1 | PCOLCE | 0.787057 | 13 | 0 | 13 |
| CHN1 | CALU | 0.786827 | 12 | 0 | 12 |
| CHN1 | PDGFRB | 0.782519 | 12 | 0 | 12 |
| CHN1 | COL3A1 | 0.779203 | 12 | 0 | 12 |
| CHN1 | TNFAIP6 | 0.777638 | 13 | 0 | 13 |
| CHN1 | FBN1 | 0.774078 | 11 | 0 | 11 |
| CHN1 | COL12A1 | 0.769171 | 9 | 0 | 8 |
| CHN1 | COL8A1 | 0.767839 | 10 | 0 | 10 |
| CHN1 | LRRC8C | 0.7657 | 3 | 0 | 3 |
For details and further investigation, click here
