| Full name: cyclin dependent kinase inhibitor 1C | Alias Symbol: P57|KIP2 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 1028 | HGNC ID: HGNC:1786 | Ensembl Gene: ENSG00000129757 | OMIM ID: 600856 |
| Drug and gene relationship at DGIdb | |||
CDKN1C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDKN1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKN1C | 1028 | 213348_at | -1.2577 | 0.0997 | |
| GSE20347 | CDKN1C | 1028 | 213348_at | -0.0351 | 0.9319 | |
| GSE23400 | CDKN1C | 1028 | 213348_at | -0.6009 | 0.0000 | |
| GSE26886 | CDKN1C | 1028 | 213348_at | 2.4314 | 0.0000 | |
| GSE29001 | CDKN1C | 1028 | 213348_at | -0.1375 | 0.7924 | |
| GSE38129 | CDKN1C | 1028 | 213348_at | -0.2674 | 0.6169 | |
| GSE45670 | CDKN1C | 1028 | 213348_at | -1.6748 | 0.0000 | |
| GSE53622 | CDKN1C | 1028 | 139632 | -0.3207 | 0.0006 | |
| GSE53624 | CDKN1C | 1028 | 139632 | -0.3873 | 0.0000 | |
| GSE63941 | CDKN1C | 1028 | 213348_at | -2.1537 | 0.0211 | |
| GSE77861 | CDKN1C | 1028 | 213348_at | 0.9495 | 0.0857 | |
| GSE97050 | CDKN1C | 1028 | A_23_P428129 | -0.7720 | 0.1297 | |
| SRP007169 | CDKN1C | 1028 | RNAseq | -0.6972 | 0.2958 | |
| SRP064894 | CDKN1C | 1028 | RNAseq | -0.6534 | 0.1277 | |
| SRP133303 | CDKN1C | 1028 | RNAseq | -0.7287 | 0.0185 | |
| SRP159526 | CDKN1C | 1028 | RNAseq | -0.9102 | 0.0094 | |
| SRP193095 | CDKN1C | 1028 | RNAseq | 0.5535 | 0.0262 | |
| TCGA | CDKN1C | 1028 | RNAseq | -0.5285 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CDKN1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKN1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKN1C | 1028 | 1 | 11 | 18 | |
| GSE20123 | CDKN1C | 1028 | 1 | 12 | 17 | |
| GSE43470 | CDKN1C | 1028 | 1 | 10 | 32 | |
| GSE46452 | CDKN1C | 1028 | 7 | 8 | 44 | |
| GSE47630 | CDKN1C | 1028 | 4 | 12 | 24 | |
| GSE54993 | CDKN1C | 1028 | 3 | 1 | 66 | |
| GSE54994 | CDKN1C | 1028 | 1 | 12 | 40 | |
| GSE60625 | CDKN1C | 1028 | 0 | 0 | 11 | |
| GSE74703 | CDKN1C | 1028 | 1 | 8 | 27 | |
| GSE74704 | CDKN1C | 1028 | 0 | 8 | 12 | |
| TCGA | CDKN1C | 1028 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of CDKN1C:
Generating mutation plots.
Highly correlated genes for CDKN1C:
Showing top 20/887 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKN1C | ZFAND3 | 0.830803 | 3 | 0 | 3 |
| CDKN1C | ING1 | 0.819291 | 3 | 0 | 3 |
| CDKN1C | RNASEH2C | 0.801953 | 3 | 0 | 3 |
| CDKN1C | TNRC18 | 0.786458 | 3 | 0 | 3 |
| CDKN1C | SIN3A | 0.773201 | 3 | 0 | 3 |
| CDKN1C | RIMKLB | 0.770955 | 3 | 0 | 3 |
| CDKN1C | DGKH | 0.76513 | 3 | 0 | 3 |
| CDKN1C | ZNF496 | 0.764026 | 3 | 0 | 3 |
| CDKN1C | PLEKHA3 | 0.763908 | 3 | 0 | 3 |
| CDKN1C | PET117 | 0.762877 | 3 | 0 | 3 |
| CDKN1C | ZHX2 | 0.758589 | 3 | 0 | 3 |
| CDKN1C | PDCD4 | 0.758187 | 3 | 0 | 3 |
| CDKN1C | KLHL13 | 0.757203 | 3 | 0 | 3 |
| CDKN1C | EID2 | 0.751052 | 3 | 0 | 3 |
| CDKN1C | CLASP1 | 0.749081 | 3 | 0 | 3 |
| CDKN1C | HCFC1R1 | 0.746565 | 4 | 0 | 4 |
| CDKN1C | MRPL33 | 0.746516 | 3 | 0 | 3 |
| CDKN1C | CDC42EP4 | 0.744463 | 3 | 0 | 3 |
| CDKN1C | SPIRE1 | 0.743299 | 3 | 0 | 3 |
| CDKN1C | TRIM47 | 0.738741 | 3 | 0 | 3 |
For details and further investigation, click here
