| Full name: CCR4-NOT transcription complex subunit 6 like | Alias Symbol: DKFZp434K098|Ccr4b | ||
| Type: protein-coding gene | Cytoband: 4q21.1 | ||
| Entrez ID: 246175 | HGNC ID: HGNC:18042 | Ensembl Gene: ENSG00000138767 | OMIM ID: 618069 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT6L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT6L | 246175 | 226153_s_at | -0.2470 | 0.6935 | |
| GSE26886 | CNOT6L | 246175 | 226153_s_at | -1.0192 | 0.0032 | |
| GSE45670 | CNOT6L | 246175 | 226153_s_at | -0.5338 | 0.0011 | |
| GSE53622 | CNOT6L | 246175 | 48308 | -0.5407 | 0.0000 | |
| GSE53624 | CNOT6L | 246175 | 48308 | -0.7775 | 0.0000 | |
| GSE63941 | CNOT6L | 246175 | 226153_s_at | 0.3556 | 0.2536 | |
| GSE77861 | CNOT6L | 246175 | 226153_s_at | -0.5197 | 0.0992 | |
| GSE97050 | CNOT6L | 246175 | A_33_P3249214 | -0.3088 | 0.2082 | |
| SRP007169 | CNOT6L | 246175 | RNAseq | -1.0216 | 0.0069 | |
| SRP008496 | CNOT6L | 246175 | RNAseq | -0.9548 | 0.0000 | |
| SRP064894 | CNOT6L | 246175 | RNAseq | -0.3989 | 0.0511 | |
| SRP133303 | CNOT6L | 246175 | RNAseq | -0.3335 | 0.0762 | |
| SRP159526 | CNOT6L | 246175 | RNAseq | -0.6847 | 0.0015 | |
| SRP193095 | CNOT6L | 246175 | RNAseq | -0.6969 | 0.0000 | |
| SRP219564 | CNOT6L | 246175 | RNAseq | -0.3024 | 0.3782 | |
| TCGA | CNOT6L | 246175 | RNAseq | -0.1748 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CNOT6L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT6L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT6L | 246175 | 2 | 9 | 19 | |
| GSE20123 | CNOT6L | 246175 | 2 | 9 | 19 | |
| GSE43470 | CNOT6L | 246175 | 1 | 12 | 30 | |
| GSE46452 | CNOT6L | 246175 | 1 | 36 | 22 | |
| GSE47630 | CNOT6L | 246175 | 1 | 19 | 20 | |
| GSE54993 | CNOT6L | 246175 | 7 | 0 | 63 | |
| GSE54994 | CNOT6L | 246175 | 0 | 9 | 44 | |
| GSE60625 | CNOT6L | 246175 | 0 | 0 | 11 | |
| GSE74703 | CNOT6L | 246175 | 1 | 10 | 25 | |
| GSE74704 | CNOT6L | 246175 | 2 | 5 | 13 | |
| TCGA | CNOT6L | 246175 | 14 | 32 | 50 |
Total number of gains: 31; Total number of losses: 141; Total Number of normals: 316.
Somatic mutations of CNOT6L:
Generating mutation plots.
Highly correlated genes for CNOT6L:
Showing top 20/1001 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT6L | SLTM | 0.765455 | 4 | 0 | 4 |
| CNOT6L | TMEM50A | 0.763922 | 4 | 0 | 4 |
| CNOT6L | SGPL1 | 0.753307 | 3 | 0 | 3 |
| CNOT6L | YTHDF2 | 0.747729 | 3 | 0 | 3 |
| CNOT6L | NIPAL3 | 0.743284 | 4 | 0 | 4 |
| CNOT6L | DCAF10 | 0.739248 | 4 | 0 | 3 |
| CNOT6L | C6orf120 | 0.736204 | 3 | 0 | 3 |
| CNOT6L | RNASEL | 0.735943 | 3 | 0 | 3 |
| CNOT6L | ZFAND1 | 0.731473 | 3 | 0 | 3 |
| CNOT6L | RCHY1 | 0.728995 | 7 | 0 | 6 |
| CNOT6L | SYPL1 | 0.72755 | 3 | 0 | 3 |
| CNOT6L | CCDC28A | 0.723598 | 7 | 0 | 7 |
| CNOT6L | PANK1 | 0.720565 | 4 | 0 | 4 |
| CNOT6L | TRAPPC8 | 0.718028 | 4 | 0 | 4 |
| CNOT6L | RBL2 | 0.7173 | 4 | 0 | 3 |
| CNOT6L | NUB1 | 0.717164 | 3 | 0 | 3 |
| CNOT6L | OGFRL1 | 0.715356 | 5 | 0 | 5 |
| CNOT6L | CCDC7 | 0.713915 | 3 | 0 | 3 |
| CNOT6L | ATP6V1B2 | 0.710018 | 3 | 0 | 3 |
| CNOT6L | CCNJ | 0.709191 | 3 | 0 | 3 |
For details and further investigation, click here
