| Full name: sphingosine-1-phosphate lyase 1 | Alias Symbol: SPL | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 8879 | HGNC ID: HGNC:10817 | Ensembl Gene: ENSG00000166224 | OMIM ID: 603729 |
| Drug and gene relationship at DGIdb | |||
Expression of SGPL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGPL1 | 8879 | 212322_at | 0.2779 | 0.7300 | |
| GSE20347 | SGPL1 | 8879 | 212322_at | -0.5113 | 0.0015 | |
| GSE23400 | SGPL1 | 8879 | 212322_at | -0.1434 | 0.1220 | |
| GSE26886 | SGPL1 | 8879 | 212322_at | -1.0164 | 0.0007 | |
| GSE29001 | SGPL1 | 8879 | 212322_at | -0.5248 | 0.0389 | |
| GSE38129 | SGPL1 | 8879 | 212322_at | 0.0599 | 0.8187 | |
| GSE45670 | SGPL1 | 8879 | 212322_at | 0.0925 | 0.5533 | |
| GSE53622 | SGPL1 | 8879 | 8021 | 0.0157 | 0.8762 | |
| GSE53624 | SGPL1 | 8879 | 63464 | -0.0772 | 0.2272 | |
| GSE63941 | SGPL1 | 8879 | 212322_at | 1.0558 | 0.0024 | |
| GSE77861 | SGPL1 | 8879 | 212322_at | -0.5754 | 0.0355 | |
| GSE97050 | SGPL1 | 8879 | A_33_P3327847 | 0.1240 | 0.5271 | |
| SRP007169 | SGPL1 | 8879 | RNAseq | -1.2059 | 0.0010 | |
| SRP008496 | SGPL1 | 8879 | RNAseq | -0.8939 | 0.0000 | |
| SRP064894 | SGPL1 | 8879 | RNAseq | -0.3420 | 0.0525 | |
| SRP133303 | SGPL1 | 8879 | RNAseq | 0.1244 | 0.4589 | |
| SRP159526 | SGPL1 | 8879 | RNAseq | -0.3870 | 0.3318 | |
| SRP193095 | SGPL1 | 8879 | RNAseq | -0.3298 | 0.0061 | |
| SRP219564 | SGPL1 | 8879 | RNAseq | -0.3323 | 0.5066 | |
| TCGA | SGPL1 | 8879 | RNAseq | 0.2124 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by SGPL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGPL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGPL1 | 8879 | 2 | 4 | 24 | |
| GSE20123 | SGPL1 | 8879 | 2 | 3 | 25 | |
| GSE43470 | SGPL1 | 8879 | 1 | 7 | 35 | |
| GSE46452 | SGPL1 | 8879 | 0 | 11 | 48 | |
| GSE47630 | SGPL1 | 8879 | 2 | 14 | 24 | |
| GSE54993 | SGPL1 | 8879 | 7 | 0 | 63 | |
| GSE54994 | SGPL1 | 8879 | 2 | 11 | 40 | |
| GSE60625 | SGPL1 | 8879 | 0 | 0 | 11 | |
| GSE74703 | SGPL1 | 8879 | 1 | 4 | 31 | |
| GSE74704 | SGPL1 | 8879 | 1 | 1 | 18 | |
| TCGA | SGPL1 | 8879 | 10 | 24 | 62 |
Total number of gains: 28; Total number of losses: 79; Total Number of normals: 381.
Somatic mutations of SGPL1:
Generating mutation plots.
Highly correlated genes for SGPL1:
Showing top 20/812 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGPL1 | ALDH5A1 | 0.775717 | 3 | 0 | 3 |
| SGPL1 | CNOT6L | 0.753307 | 3 | 0 | 3 |
| SGPL1 | BROX | 0.750784 | 3 | 0 | 3 |
| SGPL1 | WDR77 | 0.72672 | 3 | 0 | 3 |
| SGPL1 | ANKZF1 | 0.715679 | 3 | 0 | 3 |
| SGPL1 | ANKRD31 | 0.711617 | 3 | 0 | 3 |
| SGPL1 | KIAA1522 | 0.709161 | 4 | 0 | 4 |
| SGPL1 | TTC30B | 0.706457 | 3 | 0 | 3 |
| SGPL1 | FLII | 0.705918 | 3 | 0 | 3 |
| SGPL1 | BCL2L11 | 0.704932 | 3 | 0 | 3 |
| SGPL1 | CNOT10 | 0.702797 | 4 | 0 | 4 |
| SGPL1 | ATP6V1B2 | 0.696976 | 3 | 0 | 3 |
| SGPL1 | HEATR5B | 0.695454 | 3 | 0 | 3 |
| SGPL1 | AP3M1 | 0.683962 | 3 | 0 | 3 |
| SGPL1 | RAB3D | 0.6766 | 7 | 0 | 5 |
| SGPL1 | TP53RK | 0.674703 | 3 | 0 | 3 |
| SGPL1 | PDIK1L | 0.670345 | 5 | 0 | 4 |
| SGPL1 | AP1M2 | 0.66888 | 9 | 0 | 9 |
| SGPL1 | RNF149 | 0.668155 | 4 | 0 | 3 |
| SGPL1 | ZNF770 | 0.667561 | 5 | 0 | 4 |
For details and further investigation, click here
