| Full name: RB transcriptional corepressor like 2 | Alias Symbol: Rb2|p130 | ||
| Type: protein-coding gene | Cytoband: 16q12.2 | ||
| Entrez ID: 5934 | HGNC ID: HGNC:9894 | Ensembl Gene: ENSG00000103479 | OMIM ID: 180203 |
| Drug and gene relationship at DGIdb | |||
RBL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04110 | Cell cycle | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of RBL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBL2 | 5934 | 212331_at | -0.1148 | 0.8098 | |
| GSE20347 | RBL2 | 5934 | 212331_at | -0.0108 | 0.9215 | |
| GSE23400 | RBL2 | 5934 | 212331_at | -0.0074 | 0.9279 | |
| GSE26886 | RBL2 | 5934 | 212331_at | -0.1071 | 0.7167 | |
| GSE29001 | RBL2 | 5934 | 212331_at | 0.1427 | 0.5183 | |
| GSE38129 | RBL2 | 5934 | 212331_at | -0.1435 | 0.0749 | |
| GSE45670 | RBL2 | 5934 | 212331_at | -0.2100 | 0.2514 | |
| GSE53622 | RBL2 | 5934 | 48173 | -0.1123 | 0.0539 | |
| GSE53624 | RBL2 | 5934 | 48173 | -0.1679 | 0.0345 | |
| GSE63941 | RBL2 | 5934 | 212331_at | -0.0421 | 0.9332 | |
| GSE77861 | RBL2 | 5934 | 212331_at | -0.2528 | 0.5817 | |
| GSE97050 | RBL2 | 5934 | A_24_P416159 | -0.3268 | 0.2151 | |
| SRP007169 | RBL2 | 5934 | RNAseq | -0.3271 | 0.3278 | |
| SRP008496 | RBL2 | 5934 | RNAseq | -0.3355 | 0.1504 | |
| SRP064894 | RBL2 | 5934 | RNAseq | -0.6019 | 0.0535 | |
| SRP133303 | RBL2 | 5934 | RNAseq | -0.1264 | 0.3404 | |
| SRP159526 | RBL2 | 5934 | RNAseq | -0.1559 | 0.5880 | |
| SRP193095 | RBL2 | 5934 | RNAseq | -0.3206 | 0.0028 | |
| SRP219564 | RBL2 | 5934 | RNAseq | -0.6826 | 0.0412 | |
| TCGA | RBL2 | 5934 | RNAseq | -0.1285 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RBL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBL2 | 5934 | 3 | 0 | 27 | |
| GSE20123 | RBL2 | 5934 | 3 | 0 | 27 | |
| GSE43470 | RBL2 | 5934 | 2 | 7 | 34 | |
| GSE46452 | RBL2 | 5934 | 38 | 1 | 20 | |
| GSE47630 | RBL2 | 5934 | 11 | 7 | 22 | |
| GSE54993 | RBL2 | 5934 | 2 | 5 | 63 | |
| GSE54994 | RBL2 | 5934 | 6 | 10 | 37 | |
| GSE60625 | RBL2 | 5934 | 4 | 0 | 7 | |
| GSE74703 | RBL2 | 5934 | 2 | 4 | 30 | |
| GSE74704 | RBL2 | 5934 | 3 | 0 | 17 | |
| TCGA | RBL2 | 5934 | 26 | 11 | 59 |
Total number of gains: 100; Total number of losses: 45; Total Number of normals: 343.
Somatic mutations of RBL2:
Generating mutation plots.
Highly correlated genes for RBL2:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBL2 | HSD11B1 | 0.788757 | 3 | 0 | 3 |
| RBL2 | MACROD2 | 0.765289 | 3 | 0 | 3 |
| RBL2 | NUDT16 | 0.761288 | 3 | 0 | 3 |
| RBL2 | AP3M1 | 0.750734 | 3 | 0 | 3 |
| RBL2 | ST6GALNAC6 | 0.745272 | 3 | 0 | 3 |
| RBL2 | STK38L | 0.741467 | 3 | 0 | 3 |
| RBL2 | CYP4V2 | 0.729013 | 4 | 0 | 3 |
| RBL2 | RNF214 | 0.724675 | 3 | 0 | 3 |
| RBL2 | COMMD3 | 0.724091 | 4 | 0 | 3 |
| RBL2 | XPC | 0.719711 | 4 | 0 | 3 |
| RBL2 | CNOT6L | 0.7173 | 4 | 0 | 3 |
| RBL2 | ARHGEF9 | 0.713254 | 4 | 0 | 4 |
| RBL2 | RBM18 | 0.711902 | 3 | 0 | 3 |
| RBL2 | ZEB2 | 0.706679 | 3 | 0 | 3 |
| RBL2 | EPHX1 | 0.705908 | 3 | 0 | 3 |
| RBL2 | S100PBP | 0.705223 | 3 | 0 | 3 |
| RBL2 | LOXL4 | 0.702022 | 3 | 0 | 3 |
| RBL2 | C11orf68 | 0.699421 | 3 | 0 | 3 |
| RBL2 | TXNL4A | 0.69579 | 3 | 0 | 3 |
| RBL2 | CEP44 | 0.69453 | 5 | 0 | 4 |
For details and further investigation, click here
