| Full name: negative regulator of ubiquitin like proteins 1 | Alias Symbol: BS4|NYREN18|NUB1L | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 51667 | HGNC ID: HGNC:17623 | Ensembl Gene: ENSG00000013374 | OMIM ID: 607981 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NUB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUB1 | 51667 | 222512_at | -0.0464 | 0.9597 | |
| GSE26886 | NUB1 | 51667 | 222512_at | -0.2998 | 0.2665 | |
| GSE45670 | NUB1 | 51667 | 222512_at | 0.0355 | 0.8833 | |
| GSE53622 | NUB1 | 51667 | 120378 | 0.0431 | 0.7031 | |
| GSE53624 | NUB1 | 51667 | 120378 | 0.1388 | 0.2262 | |
| GSE63941 | NUB1 | 51667 | 1569030_s_at | -0.0895 | 0.9021 | |
| GSE77861 | NUB1 | 51667 | 222512_at | 0.1693 | 0.3502 | |
| GSE97050 | NUB1 | 51667 | A_23_P215154 | -0.0714 | 0.8026 | |
| SRP007169 | NUB1 | 51667 | RNAseq | 1.1434 | 0.0350 | |
| SRP008496 | NUB1 | 51667 | RNAseq | 1.0323 | 0.0024 | |
| SRP064894 | NUB1 | 51667 | RNAseq | 0.5176 | 0.0001 | |
| SRP133303 | NUB1 | 51667 | RNAseq | 0.2865 | 0.1371 | |
| SRP159526 | NUB1 | 51667 | RNAseq | 0.2461 | 0.4278 | |
| SRP193095 | NUB1 | 51667 | RNAseq | 0.1906 | 0.1316 | |
| SRP219564 | NUB1 | 51667 | RNAseq | 0.1750 | 0.5965 | |
| TCGA | NUB1 | 51667 | RNAseq | 0.0036 | 0.9418 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NUB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUB1 | 51667 | 2 | 4 | 24 | |
| GSE20123 | NUB1 | 51667 | 2 | 4 | 24 | |
| GSE43470 | NUB1 | 51667 | 2 | 5 | 36 | |
| GSE46452 | NUB1 | 51667 | 7 | 2 | 50 | |
| GSE47630 | NUB1 | 51667 | 5 | 9 | 26 | |
| GSE54993 | NUB1 | 51667 | 3 | 3 | 64 | |
| GSE54994 | NUB1 | 51667 | 5 | 8 | 40 | |
| GSE60625 | NUB1 | 51667 | 0 | 0 | 11 | |
| GSE74703 | NUB1 | 51667 | 2 | 4 | 30 | |
| GSE74704 | NUB1 | 51667 | 1 | 4 | 15 | |
| TCGA | NUB1 | 51667 | 27 | 25 | 44 |
Total number of gains: 56; Total number of losses: 68; Total Number of normals: 364.
Somatic mutations of NUB1:
Generating mutation plots.
Highly correlated genes for NUB1:
Showing top 20/406 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUB1 | ZNF506 | 0.818252 | 3 | 0 | 3 |
| NUB1 | ZFP30 | 0.783692 | 3 | 0 | 3 |
| NUB1 | DHPS | 0.781715 | 3 | 0 | 3 |
| NUB1 | C1orf122 | 0.779419 | 3 | 0 | 3 |
| NUB1 | SEC24D | 0.776592 | 3 | 0 | 3 |
| NUB1 | DOCK7 | 0.774314 | 3 | 0 | 3 |
| NUB1 | QTRT1 | 0.772931 | 3 | 0 | 3 |
| NUB1 | PMF1 | 0.767889 | 3 | 0 | 3 |
| NUB1 | TXLNG | 0.763659 | 3 | 0 | 3 |
| NUB1 | TOP2B | 0.762294 | 3 | 0 | 3 |
| NUB1 | EIF3G | 0.759435 | 3 | 0 | 3 |
| NUB1 | DHRS3 | 0.752965 | 3 | 0 | 3 |
| NUB1 | RNF125 | 0.752537 | 4 | 0 | 4 |
| NUB1 | TBCC | 0.75164 | 3 | 0 | 3 |
| NUB1 | LRRC41 | 0.750365 | 3 | 0 | 3 |
| NUB1 | ELOF1 | 0.749321 | 3 | 0 | 3 |
| NUB1 | PPP2R3C | 0.7485 | 4 | 0 | 4 |
| NUB1 | PRKAG1 | 0.748499 | 3 | 0 | 3 |
| NUB1 | BIVM | 0.743822 | 3 | 0 | 3 |
| NUB1 | DR1 | 0.742963 | 3 | 0 | 3 |
For details and further investigation, click here
