| Full name: pantothenate kinase 1 | Alias Symbol: MGC24596|PANK1a|PANK1b | ||
| Type: protein-coding gene | Cytoband: 10q23.31 | ||
| Entrez ID: 53354 | HGNC ID: HGNC:8598 | Ensembl Gene: ENSG00000152782 | OMIM ID: 606160 |
| Drug and gene relationship at DGIdb | |||
Expression of PANK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PANK1 | 53354 | 226649_at | -0.2994 | 0.7581 | |
| GSE26886 | PANK1 | 53354 | 226649_at | -1.5575 | 0.0000 | |
| GSE45670 | PANK1 | 53354 | 226649_at | -0.2703 | 0.3775 | |
| GSE53622 | PANK1 | 53354 | 85565 | -1.0175 | 0.0000 | |
| GSE53624 | PANK1 | 53354 | 85565 | -1.1076 | 0.0000 | |
| GSE63941 | PANK1 | 53354 | 226649_at | 0.2195 | 0.7802 | |
| GSE77861 | PANK1 | 53354 | 226649_at | -0.4079 | 0.1057 | |
| GSE97050 | PANK1 | 53354 | A_33_P3227788 | -0.2408 | 0.2659 | |
| SRP007169 | PANK1 | 53354 | RNAseq | -1.5616 | 0.0014 | |
| SRP008496 | PANK1 | 53354 | RNAseq | -1.0258 | 0.0062 | |
| SRP064894 | PANK1 | 53354 | RNAseq | -0.9306 | 0.0000 | |
| SRP133303 | PANK1 | 53354 | RNAseq | -0.5262 | 0.0590 | |
| SRP159526 | PANK1 | 53354 | RNAseq | -0.4879 | 0.1160 | |
| SRP193095 | PANK1 | 53354 | RNAseq | -1.0837 | 0.0000 | |
| SRP219564 | PANK1 | 53354 | RNAseq | -1.1414 | 0.0076 | |
| TCGA | PANK1 | 53354 | RNAseq | -0.3780 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PANK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PANK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PANK1 | 53354 | 2 | 7 | 21 | |
| GSE20123 | PANK1 | 53354 | 2 | 6 | 22 | |
| GSE43470 | PANK1 | 53354 | 0 | 8 | 35 | |
| GSE46452 | PANK1 | 53354 | 0 | 11 | 48 | |
| GSE47630 | PANK1 | 53354 | 2 | 14 | 24 | |
| GSE54993 | PANK1 | 53354 | 7 | 0 | 63 | |
| GSE54994 | PANK1 | 53354 | 1 | 11 | 41 | |
| GSE60625 | PANK1 | 53354 | 0 | 0 | 11 | |
| GSE74703 | PANK1 | 53354 | 0 | 6 | 30 | |
| GSE74704 | PANK1 | 53354 | 1 | 4 | 15 | |
| TCGA | PANK1 | 53354 | 7 | 27 | 62 |
Total number of gains: 22; Total number of losses: 94; Total Number of normals: 372.
Somatic mutations of PANK1:
Generating mutation plots.
Highly correlated genes for PANK1:
Showing top 20/1216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PANK1 | ACAP2 | 0.799546 | 3 | 0 | 3 |
| PANK1 | TBK1 | 0.798674 | 3 | 0 | 3 |
| PANK1 | LARP4 | 0.787616 | 3 | 0 | 3 |
| PANK1 | CTDSPL | 0.776323 | 3 | 0 | 3 |
| PANK1 | SOCS6 | 0.767088 | 4 | 0 | 4 |
| PANK1 | PIK3CB | 0.76054 | 3 | 0 | 3 |
| PANK1 | POLE3 | 0.758785 | 3 | 0 | 3 |
| PANK1 | PRDM2 | 0.757342 | 4 | 0 | 4 |
| PANK1 | ECD | 0.75444 | 3 | 0 | 3 |
| PANK1 | C2CD2 | 0.750916 | 3 | 0 | 3 |
| PANK1 | USP24 | 0.746418 | 3 | 0 | 3 |
| PANK1 | ZFC3H1 | 0.746073 | 3 | 0 | 3 |
| PANK1 | ZMPSTE24 | 0.739909 | 3 | 0 | 3 |
| PANK1 | ZNF717 | 0.739253 | 3 | 0 | 3 |
| PANK1 | PFDN5 | 0.736095 | 3 | 0 | 3 |
| PANK1 | ARL16 | 0.733188 | 3 | 0 | 3 |
| PANK1 | GDAP2 | 0.731399 | 3 | 0 | 3 |
| PANK1 | ZNF823 | 0.730994 | 7 | 0 | 7 |
| PANK1 | ZNF416 | 0.730916 | 5 | 0 | 4 |
| PANK1 | RCAN3 | 0.730482 | 5 | 0 | 4 |
For details and further investigation, click here
