SENP1

 

Full name: SUMO specific peptidase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q13.11
Entrez ID: 29843 HGNC ID: HGNC:17927 Ensembl Gene: ENSG00000079387 OMIM ID: 612157
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SENP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SENP1 29843 226619_at 0.4026 0.2893
GSE26886 SENP1 29843 226619_at 0.4284 0.0846
GSE45670 SENP1 29843 226619_at 0.0844 0.5111
GSE53622 SENP1 29843 20474 -0.0690 0.5263
GSE53624 SENP1 29843 20474 -0.2314 0.0774
GSE63941 SENP1 29843 226619_at 0.2108 0.4968
GSE77861 SENP1 29843 226619_at 0.2778 0.0271
GSE97050 SENP1 29843 A_33_P3304528 -0.1714 0.5435
SRP007169 SENP1 29843 RNAseq 0.3961 0.3081
SRP008496 SENP1 29843 RNAseq 0.5298 0.0105
SRP064894 SENP1 29843 RNAseq 0.3198 0.0544
SRP133303 SENP1 29843 RNAseq 0.5729 0.0030
SRP159526 SENP1 29843 RNAseq 0.5669 0.0115
SRP193095 SENP1 29843 RNAseq 0.5200 0.0002
SRP219564 SENP1 29843 RNAseq 0.3119 0.2573
TCGA SENP1 29843 RNAseq 0.1890 0.0004

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SENP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SENP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SENP1 29843 7 1 22
GSE20123 SENP1 29843 7 1 22
GSE43470 SENP1 29843 3 1 39
GSE46452 SENP1 29843 8 1 50
GSE47630 SENP1 29843 11 2 27
GSE54993 SENP1 29843 0 5 65
GSE54994 SENP1 29843 6 1 46
GSE60625 SENP1 29843 0 0 11
GSE74703 SENP1 29843 3 1 32
GSE74704 SENP1 29843 4 1 15
TCGA SENP1 29843 16 12 68

Total number of gains: 65; Total number of losses: 26; Total Number of normals: 397.  

 

Somatic mutations of SENP1:

 

Generating mutation plots.

 

Highly correlated genes for SENP1:

 

Showing top 20/447 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SENP1LRRC580.814552303
SENP1MED260.81077303
SENP1ZNF30.798721303
SENP1KIR3DL20.769406303
SENP1AGPS0.768684303
SENP1RIOK10.768044303
SENP1RNF1380.765826303
SENP1KDM5A0.765787303
SENP1COCH0.76507303
SENP1RNPS10.76387303
SENP1CRKL0.760429303
SENP1LRRC340.758824303
SENP1TOPBP10.755316404
SENP1SERPINB100.753216303
SENP1TMEM150A0.753194303
SENP1POGLUT10.753181303
SENP1EMG10.752713303
SENP1ZBTB410.75258303
SENP1SKA10.752172303
SENP1M6PR0.746246303

For details and further investigation, click here