CRK

 

Full name: CRK proto-oncogene, adaptor protein Alias Symbol: 
Type: protein-coding gene Cytoband: 17p13.3
Entrez ID: 1398 HGNC ID: HGNC:2362 Ensembl Gene: ENSG00000167193 OMIM ID: 164762
Drug and gene relationship at DGIdb
Screen Evidence:

 

CRK involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04666Fc gamma R-mediated phagocytosis
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia

 

Expression of CRK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CRK 1398 202225_at 0.1614 0.5862
GSE20347 CRK 1398 202224_at 0.1075 0.3328
GSE23400 CRK 1398 202226_s_at 0.0634 0.2075
GSE26886 CRK 1398 202225_at -0.5954 0.0004
GSE29001 CRK 1398 202225_at -0.0276 0.9446
GSE38129 CRK 1398 202225_at -0.0755 0.4995
GSE45670 CRK 1398 202225_at 0.0488 0.6463
GSE53622 CRK 1398 128696 0.2697 0.0000
GSE53624 CRK 1398 128696 0.0915 0.3187
GSE63941 CRK 1398 202226_s_at 0.9210 0.0228
GSE77861 CRK 1398 202225_at 0.0008 0.9980
GSE97050 CRK 1398 A_24_P270814 0.1890 0.4333
SRP007169 CRK 1398 RNAseq 0.0891 0.7849
SRP008496 CRK 1398 RNAseq 0.2121 0.2839
SRP064894 CRK 1398 RNAseq -0.0838 0.5139
SRP133303 CRK 1398 RNAseq 0.1075 0.3677
SRP159526 CRK 1398 RNAseq 0.0904 0.6657
SRP193095 CRK 1398 RNAseq -0.0251 0.8023
SRP219564 CRK 1398 RNAseq -0.0273 0.9018
TCGA CRK 1398 RNAseq -0.0398 0.3829

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CRK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CRK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CRK 1398 5 2 23
GSE20123 CRK 1398 5 3 22
GSE43470 CRK 1398 3 6 34
GSE46452 CRK 1398 34 1 24
GSE47630 CRK 1398 8 1 31
GSE54993 CRK 1398 9 3 58
GSE54994 CRK 1398 7 9 37
GSE60625 CRK 1398 4 0 7
GSE74703 CRK 1398 2 3 31
GSE74704 CRK 1398 3 1 16
TCGA CRK 1398 19 21 56

Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.  

 

Somatic mutations of CRK:

 

Generating mutation plots.

 

Highly correlated genes for CRK:

 

Showing top 20/485 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CRKCNOT100.836822303
CRKCHD10.789844303
CRKCOCH0.783273303
CRKATXN70.772805303
CRKZNF2270.75116303
CRKSNRNP2000.746338303
CRKXPO40.735595303
CRKPPP4R20.734535303
CRKALG140.722781303
CRKSTAU20.719563303
CRKBLOC1S20.719507303
CRKARL13B0.716241404
CRKOXSM0.713751303
CRKFAM114A20.71195303
CRKMTMR90.709579303
CRKCHCHD40.709323403
CRKRNGTT0.708303505
CRKARPC50.7069404
CRKLTN10.705757303
CRKCMTM40.703573403

For details and further investigation, click here