| Full name: adenylate kinase 3 | Alias Symbol: AKL3L1 | ||
| Type: protein-coding gene | Cytoband: 9p24.1 | ||
| Entrez ID: 50808 | HGNC ID: HGNC:17376 | Ensembl Gene: ENSG00000147853 | OMIM ID: 609290 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AK3 | 50808 | 224655_at | -0.6436 | 0.0642 | |
| GSE26886 | AK3 | 50808 | 224655_at | -0.9630 | 0.0000 | |
| GSE45670 | AK3 | 50808 | 224655_at | -0.5360 | 0.0006 | |
| GSE53622 | AK3 | 50808 | 84884 | -1.1405 | 0.0000 | |
| GSE53624 | AK3 | 50808 | 84884 | -1.0727 | 0.0000 | |
| GSE63941 | AK3 | 50808 | 224655_at | -2.3140 | 0.0069 | |
| GSE77861 | AK3 | 50808 | 224655_at | -0.5294 | 0.1108 | |
| GSE97050 | AK3 | 50808 | A_24_P247106 | -0.7454 | 0.0938 | |
| SRP007169 | AK3 | 50808 | RNAseq | -1.8641 | 0.0001 | |
| SRP008496 | AK3 | 50808 | RNAseq | -1.5562 | 0.0000 | |
| SRP064894 | AK3 | 50808 | RNAseq | -0.7217 | 0.0003 | |
| SRP133303 | AK3 | 50808 | RNAseq | -0.6423 | 0.0006 | |
| SRP159526 | AK3 | 50808 | RNAseq | -1.0631 | 0.0000 | |
| SRP193095 | AK3 | 50808 | RNAseq | -1.1159 | 0.0000 | |
| SRP219564 | AK3 | 50808 | RNAseq | -0.8523 | 0.0002 | |
| TCGA | AK3 | 50808 | RNAseq | -0.3122 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by AK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AK3 | 50808 | 1 | 17 | 12 | |
| GSE20123 | AK3 | 50808 | 1 | 16 | 13 | |
| GSE43470 | AK3 | 50808 | 4 | 11 | 28 | |
| GSE46452 | AK3 | 50808 | 2 | 23 | 34 | |
| GSE47630 | AK3 | 50808 | 5 | 26 | 9 | |
| GSE54993 | AK3 | 50808 | 6 | 3 | 61 | |
| GSE54994 | AK3 | 50808 | 9 | 17 | 27 | |
| GSE60625 | AK3 | 50808 | 0 | 2 | 9 | |
| GSE74703 | AK3 | 50808 | 4 | 8 | 24 | |
| GSE74704 | AK3 | 50808 | 0 | 12 | 8 | |
| TCGA | AK3 | 50808 | 14 | 50 | 32 |
Total number of gains: 46; Total number of losses: 185; Total Number of normals: 257.
Somatic mutations of AK3:
Generating mutation plots.
Highly correlated genes for AK3:
Showing top 20/1666 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AK3 | FBXO8 | 0.80731 | 7 | 0 | 7 |
| AK3 | KDM3A | 0.800916 | 3 | 0 | 3 |
| AK3 | TBCA | 0.798496 | 3 | 0 | 3 |
| AK3 | GPD1L | 0.796508 | 7 | 0 | 7 |
| AK3 | UHRF1BP1L | 0.796106 | 3 | 0 | 3 |
| AK3 | STK38 | 0.795354 | 4 | 0 | 4 |
| AK3 | KANK1 | 0.792756 | 8 | 0 | 8 |
| AK3 | SUCLG2 | 0.792435 | 7 | 0 | 7 |
| AK3 | ASAH1 | 0.791589 | 6 | 0 | 6 |
| AK3 | DLD | 0.789032 | 4 | 0 | 4 |
| AK3 | KIF13B | 0.786991 | 5 | 0 | 5 |
| AK3 | CAMK2G | 0.78564 | 3 | 0 | 3 |
| AK3 | IMPACT | 0.783513 | 3 | 0 | 3 |
| AK3 | BRK1 | 0.779966 | 7 | 0 | 7 |
| AK3 | FAM214A | 0.778559 | 6 | 0 | 6 |
| AK3 | CAB39L | 0.778142 | 7 | 0 | 7 |
| AK3 | CETN2 | 0.776909 | 3 | 0 | 3 |
| AK3 | PPP2CB | 0.774606 | 4 | 0 | 4 |
| AK3 | CRBN | 0.774176 | 5 | 0 | 5 |
| AK3 | CLEC3B | 0.773994 | 3 | 0 | 3 |
For details and further investigation, click here
