CREB3L1

 

Full name: cAMP responsive element binding protein 3 like 1 Alias Symbol: OASIS
Type: protein-coding gene Cytoband: 11p11.2
Entrez ID: 90993 HGNC ID: HGNC:18856 Ensembl Gene: ENSG00000157613 OMIM ID: 616215
Drug and gene relationship at DGIdb

 

CREB3L1 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB3L1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB3L1 90993 213059_at 0.2349 0.6820
GSE20347 CREB3L1 90993 213059_at 0.5902 0.0000
GSE23400 CREB3L1 90993 213059_at 0.2256 0.0011
GSE26886 CREB3L1 90993 213059_at 0.6468 0.0210
GSE29001 CREB3L1 90993 213059_at 0.1251 0.6571
GSE38129 CREB3L1 90993 213059_at 0.3787 0.0598
GSE45670 CREB3L1 90993 213059_at -0.1043 0.6001
GSE53622 CREB3L1 90993 143403 0.9384 0.0000
GSE53624 CREB3L1 90993 143403 0.7671 0.0000
GSE63941 CREB3L1 90993 213059_at -2.1315 0.0026
GSE77861 CREB3L1 90993 213059_at 0.2482 0.1714
GSE97050 CREB3L1 90993 A_23_P150407 0.5336 0.1372
SRP007169 CREB3L1 90993 RNAseq 6.5529 0.0000
SRP064894 CREB3L1 90993 RNAseq 1.2021 0.0063
SRP133303 CREB3L1 90993 RNAseq 0.6725 0.2399
SRP159526 CREB3L1 90993 RNAseq 0.7270 0.1216
SRP219564 CREB3L1 90993 RNAseq 2.2702 0.0057
TCGA CREB3L1 90993 RNAseq -0.6683 0.0000

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by CREB3L1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB3L1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB3L1 90993 3 7 20
GSE20123 CREB3L1 90993 3 6 21
GSE43470 CREB3L1 90993 2 5 36
GSE46452 CREB3L1 90993 8 5 46
GSE47630 CREB3L1 90993 3 9 28
GSE54993 CREB3L1 90993 3 0 67
GSE54994 CREB3L1 90993 1 10 42
GSE60625 CREB3L1 90993 0 0 11
GSE74703 CREB3L1 90993 2 2 32
GSE74704 CREB3L1 90993 2 4 14
TCGA CREB3L1 90993 16 19 61

Total number of gains: 43; Total number of losses: 67; Total Number of normals: 378.  

 

Somatic mutations of CREB3L1:

 

Generating mutation plots.

 

Highly correlated genes for CREB3L1:

 

Showing top 20/783 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB3L1RAB11FIP50.76442303
CREB3L1KIAA12110.741481303
CREB3L1URM10.725181303
CREB3L1RAPH10.716447303
CREB3L1CLDN110.711996404
CREB3L1FMOD0.71107211010
CREB3L1LTA0.699127404
CREB3L1R3HDM20.697104303
CREB3L1DGKZ0.694358303
CREB3L1C11orf960.693269303
CREB3L1DDRGK10.686517303
CREB3L1KCNC40.685759303
CREB3L1LPP-AS20.684954303
CREB3L1GPR1530.679016504
CREB3L1FBXL180.677669303
CREB3L1ZNF3580.677164303
CREB3L1DPP70.675449303
CREB3L1TMEM200A0.672996605
CREB3L1IL13RA20.672815605
CREB3L1SPHK20.672628303

For details and further investigation, click here