| Full name: lymphotoxin alpha | Alias Symbol: TNFSF1|LT | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 4049 | HGNC ID: HGNC:6709 | Ensembl Gene: ENSG00000226979 | OMIM ID: 153440 |
| Drug and gene relationship at DGIdb | |||
LTA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04668 | TNF signaling pathway |
Expression of LTA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTA | 4049 | 206975_at | 0.0909 | 0.6999 | |
| GSE20347 | LTA | 4049 | 206975_at | -0.0600 | 0.4863 | |
| GSE23400 | LTA | 4049 | 206975_at | -0.0679 | 0.0912 | |
| GSE26886 | LTA | 4049 | 206975_at | 0.1012 | 0.4274 | |
| GSE29001 | LTA | 4049 | 206975_at | -0.1993 | 0.1597 | |
| GSE38129 | LTA | 4049 | 206975_at | -0.1569 | 0.0256 | |
| GSE45670 | LTA | 4049 | 206975_at | -0.0000 | 0.9998 | |
| GSE53622 | LTA | 4049 | 42426 | 0.5918 | 0.0000 | |
| GSE53624 | LTA | 4049 | 42426 | 0.3966 | 0.0000 | |
| GSE63941 | LTA | 4049 | 206975_at | 0.0281 | 0.8668 | |
| GSE77861 | LTA | 4049 | 206975_at | -0.0079 | 0.9515 | |
| GSE97050 | LTA | 4049 | A_23_P156683 | 0.9497 | 0.1163 | |
| TCGA | LTA | 4049 | RNAseq | 1.1160 | 0.0136 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LTA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTA | 4049 | 5 | 1 | 24 | |
| GSE20123 | LTA | 4049 | 5 | 1 | 24 | |
| GSE43470 | LTA | 4049 | 6 | 3 | 34 | |
| GSE46452 | LTA | 4049 | 1 | 10 | 48 | |
| GSE47630 | LTA | 4049 | 7 | 5 | 28 | |
| GSE54993 | LTA | 4049 | 2 | 1 | 67 | |
| GSE54994 | LTA | 4049 | 11 | 4 | 38 | |
| GSE60625 | LTA | 4049 | 0 | 1 | 10 | |
| GSE74703 | LTA | 4049 | 6 | 1 | 29 | |
| GSE74704 | LTA | 4049 | 2 | 0 | 18 | |
| TCGA | LTA | 4049 | 16 | 16 | 64 |
Total number of gains: 61; Total number of losses: 43; Total Number of normals: 384.
Somatic mutations of LTA:
Generating mutation plots.
Highly correlated genes for LTA:
Showing top 20/702 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTA | MEIS3 | 0.745802 | 3 | 0 | 3 |
| LTA | PLCB2 | 0.72325 | 6 | 0 | 6 |
| LTA | MUC16 | 0.712604 | 3 | 0 | 3 |
| LTA | C11orf72 | 0.704723 | 3 | 0 | 3 |
| LTA | GJB1 | 0.701335 | 5 | 0 | 4 |
| LTA | CREB3L1 | 0.699127 | 4 | 0 | 4 |
| LTA | LMAN1 | 0.699053 | 4 | 0 | 3 |
| LTA | ZDHHC24 | 0.697088 | 3 | 0 | 3 |
| LTA | SPX | 0.690363 | 5 | 0 | 5 |
| LTA | C16orf71 | 0.675518 | 3 | 0 | 3 |
| LTA | RPS6KA4 | 0.674958 | 4 | 0 | 4 |
| LTA | C4BPB | 0.674223 | 4 | 0 | 4 |
| LTA | RBP5 | 0.673005 | 3 | 0 | 3 |
| LTA | MCC | 0.672945 | 3 | 0 | 3 |
| LTA | ZNF469 | 0.667601 | 3 | 0 | 3 |
| LTA | KCND3 | 0.665325 | 4 | 0 | 4 |
| LTA | CIITA | 0.660559 | 7 | 0 | 5 |
| LTA | LZTS1 | 0.659957 | 7 | 0 | 5 |
| LTA | SPINK4 | 0.659472 | 4 | 0 | 4 |
| LTA | RUNX1T1 | 0.6577 | 3 | 0 | 3 |
For details and further investigation, click here
