| Full name: diacylglycerol kinase zeta | Alias Symbol: DAGK5|hDGKzeta|DGK-ZETA|DAGK6 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 8525 | HGNC ID: HGNC:2857 | Ensembl Gene: ENSG00000149091 | OMIM ID: 601441 |
| Drug and gene relationship at DGIdb | |||
Expression of DGKZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGKZ | 8525 | 207556_s_at | 0.7218 | 0.1747 | |
| GSE20347 | DGKZ | 8525 | 207556_s_at | 0.4207 | 0.0024 | |
| GSE23400 | DGKZ | 8525 | 207556_s_at | 0.3742 | 0.0000 | |
| GSE26886 | DGKZ | 8525 | 207556_s_at | 0.7300 | 0.0003 | |
| GSE29001 | DGKZ | 8525 | 207556_s_at | 0.0781 | 0.7817 | |
| GSE38129 | DGKZ | 8525 | 207556_s_at | 0.4714 | 0.0003 | |
| GSE45670 | DGKZ | 8525 | 207556_s_at | 0.3542 | 0.0026 | |
| GSE53622 | DGKZ | 8525 | 55294 | 0.2698 | 0.0000 | |
| GSE53624 | DGKZ | 8525 | 55294 | 0.4638 | 0.0000 | |
| GSE63941 | DGKZ | 8525 | 207556_s_at | 0.4158 | 0.3810 | |
| GSE77861 | DGKZ | 8525 | 207556_s_at | 0.3576 | 0.0495 | |
| GSE97050 | DGKZ | 8525 | A_33_P3239338 | 0.3295 | 0.2592 | |
| SRP007169 | DGKZ | 8525 | RNAseq | 0.2298 | 0.6795 | |
| SRP008496 | DGKZ | 8525 | RNAseq | 0.5713 | 0.0818 | |
| SRP064894 | DGKZ | 8525 | RNAseq | 0.6916 | 0.0000 | |
| SRP133303 | DGKZ | 8525 | RNAseq | 0.2743 | 0.0958 | |
| SRP159526 | DGKZ | 8525 | RNAseq | 0.1397 | 0.5194 | |
| SRP193095 | DGKZ | 8525 | RNAseq | 0.5589 | 0.0026 | |
| SRP219564 | DGKZ | 8525 | RNAseq | 0.3707 | 0.2305 | |
| TCGA | DGKZ | 8525 | RNAseq | 0.0579 | 0.2626 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DGKZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGKZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGKZ | 8525 | 3 | 7 | 20 | |
| GSE20123 | DGKZ | 8525 | 3 | 6 | 21 | |
| GSE43470 | DGKZ | 8525 | 2 | 5 | 36 | |
| GSE46452 | DGKZ | 8525 | 8 | 5 | 46 | |
| GSE47630 | DGKZ | 8525 | 3 | 9 | 28 | |
| GSE54993 | DGKZ | 8525 | 3 | 0 | 67 | |
| GSE54994 | DGKZ | 8525 | 1 | 10 | 42 | |
| GSE60625 | DGKZ | 8525 | 0 | 0 | 11 | |
| GSE74703 | DGKZ | 8525 | 2 | 2 | 32 | |
| GSE74704 | DGKZ | 8525 | 2 | 4 | 14 | |
| TCGA | DGKZ | 8525 | 16 | 19 | 61 |
Total number of gains: 43; Total number of losses: 67; Total Number of normals: 378.
Somatic mutations of DGKZ:
Generating mutation plots.
Highly correlated genes for DGKZ:
Showing top 20/502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGKZ | HAGLROS | 0.786428 | 3 | 0 | 3 |
| DGKZ | IL22RA2 | 0.725302 | 3 | 0 | 3 |
| DGKZ | PSTPIP1 | 0.711713 | 4 | 0 | 3 |
| DGKZ | OR4F21 | 0.702919 | 3 | 0 | 3 |
| DGKZ | G6PD | 0.702772 | 3 | 0 | 3 |
| DGKZ | FASTK | 0.69741 | 4 | 0 | 3 |
| DGKZ | CREB3L1 | 0.694358 | 3 | 0 | 3 |
| DGKZ | POLL | 0.691224 | 3 | 0 | 3 |
| DGKZ | KCNK9 | 0.685721 | 3 | 0 | 3 |
| DGKZ | LRFN1 | 0.684496 | 5 | 0 | 3 |
| DGKZ | OR7A17 | 0.683264 | 3 | 0 | 3 |
| DGKZ | FUT7 | 0.681266 | 3 | 0 | 3 |
| DGKZ | C4orf47 | 0.681043 | 3 | 0 | 3 |
| DGKZ | S1PR4 | 0.676614 | 3 | 0 | 3 |
| DGKZ | POU4F1 | 0.675014 | 4 | 0 | 3 |
| DGKZ | CSGALNACT2 | 0.674212 | 3 | 0 | 3 |
| DGKZ | SLC22A31 | 0.66628 | 3 | 0 | 3 |
| DGKZ | TERT | 0.666215 | 3 | 0 | 3 |
| DGKZ | FERMT3 | 0.661293 | 3 | 0 | 3 |
| DGKZ | TDRD10 | 0.659591 | 3 | 0 | 3 |
For details and further investigation, click here
