| Full name: claudin 11 | Alias Symbol: OSP | ||
| Type: protein-coding gene | Cytoband: 3q26.2 | ||
| Entrez ID: 5010 | HGNC ID: HGNC:8514 | Ensembl Gene: ENSG00000013297 | OMIM ID: 601326 |
| Drug and gene relationship at DGIdb | |||
CLDN11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN11 | 5010 | 228335_at | -2.3510 | 0.0559 | |
| GSE20347 | CLDN11 | 5010 | 206908_s_at | 0.0121 | 0.9182 | |
| GSE23400 | CLDN11 | 5010 | 206908_s_at | -0.2122 | 0.0000 | |
| GSE26886 | CLDN11 | 5010 | 206908_s_at | 0.2479 | 0.0865 | |
| GSE29001 | CLDN11 | 5010 | 206908_s_at | 0.0756 | 0.7171 | |
| GSE38129 | CLDN11 | 5010 | 206908_s_at | -0.1011 | 0.2177 | |
| GSE45670 | CLDN11 | 5010 | 228335_at | -2.4844 | 0.0000 | |
| GSE53622 | CLDN11 | 5010 | 147584 | -1.3918 | 0.0000 | |
| GSE53624 | CLDN11 | 5010 | 147584 | -1.6800 | 0.0000 | |
| GSE63941 | CLDN11 | 5010 | 228335_at | -6.4704 | 0.0008 | |
| GSE77861 | CLDN11 | 5010 | 206908_s_at | -0.1523 | 0.0787 | |
| GSE97050 | CLDN11 | 5010 | A_33_P3255404 | 0.0229 | 0.9340 | |
| SRP064894 | CLDN11 | 5010 | RNAseq | -1.1970 | 0.0001 | |
| SRP133303 | CLDN11 | 5010 | RNAseq | -1.5023 | 0.0000 | |
| SRP159526 | CLDN11 | 5010 | RNAseq | -0.3514 | 0.5890 | |
| SRP193095 | CLDN11 | 5010 | RNAseq | 0.5974 | 0.0190 | |
| SRP219564 | CLDN11 | 5010 | RNAseq | -0.3954 | 0.5026 | |
| TCGA | CLDN11 | 5010 | RNAseq | -0.5971 | 0.0407 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by CLDN11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN11 | 5010 | 22 | 0 | 8 | |
| GSE20123 | CLDN11 | 5010 | 22 | 0 | 8 | |
| GSE43470 | CLDN11 | 5010 | 24 | 0 | 19 | |
| GSE46452 | CLDN11 | 5010 | 19 | 1 | 39 | |
| GSE47630 | CLDN11 | 5010 | 27 | 2 | 11 | |
| GSE54993 | CLDN11 | 5010 | 1 | 14 | 55 | |
| GSE54994 | CLDN11 | 5010 | 41 | 0 | 12 | |
| GSE60625 | CLDN11 | 5010 | 0 | 6 | 5 | |
| GSE74703 | CLDN11 | 5010 | 20 | 0 | 16 | |
| GSE74704 | CLDN11 | 5010 | 14 | 0 | 6 | |
| TCGA | CLDN11 | 5010 | 80 | 0 | 16 |
Total number of gains: 270; Total number of losses: 23; Total Number of normals: 195.
Somatic mutations of CLDN11:
Generating mutation plots.
Highly correlated genes for CLDN11:
Showing top 20/813 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN11 | LINC01279 | 0.814707 | 3 | 0 | 3 |
| CLDN11 | NR2F1 | 0.802724 | 3 | 0 | 3 |
| CLDN11 | LINC01082 | 0.775092 | 5 | 0 | 5 |
| CLDN11 | TMEM100 | 0.77292 | 5 | 0 | 5 |
| CLDN11 | IL13RA2 | 0.738823 | 3 | 0 | 3 |
| CLDN11 | ASPA | 0.735983 | 7 | 0 | 6 |
| CLDN11 | RAPGEF1 | 0.734833 | 4 | 0 | 4 |
| CLDN11 | CXCL12 | 0.730967 | 6 | 0 | 6 |
| CLDN11 | GPRASP2 | 0.730735 | 3 | 0 | 3 |
| CLDN11 | ARSG | 0.727398 | 3 | 0 | 3 |
| CLDN11 | ARHGAP31 | 0.727387 | 6 | 0 | 5 |
| CLDN11 | FIBIN | 0.722527 | 4 | 0 | 4 |
| CLDN11 | XPC | 0.719582 | 4 | 0 | 3 |
| CLDN11 | GFRA1 | 0.71674 | 8 | 0 | 7 |
| CLDN11 | RERG | 0.712829 | 5 | 0 | 5 |
| CLDN11 | RERGL | 0.712666 | 5 | 0 | 5 |
| CLDN11 | CREB3L1 | 0.711996 | 4 | 0 | 4 |
| CLDN11 | EBF1 | 0.711211 | 6 | 0 | 6 |
| CLDN11 | CNRIP1 | 0.711151 | 6 | 0 | 5 |
| CLDN11 | CCDC3 | 0.710601 | 5 | 0 | 4 |
For details and further investigation, click here
