| Full name: C-reactive protein | Alias Symbol: PTX1 | ||
| Type: protein-coding gene | Cytoband: 1q23.2 | ||
| Entrez ID: 1401 | HGNC ID: HGNC:2367 | Ensembl Gene: ENSG00000132693 | OMIM ID: 123260 |
| Drug and gene relationship at DGIdb | |||
Expression of CRP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRP | 1401 | 205753_at | 0.0802 | 0.7791 | |
| GSE20347 | CRP | 1401 | 205753_at | 0.0790 | 0.4415 | |
| GSE23400 | CRP | 1401 | 205753_at | -0.2181 | 0.0000 | |
| GSE26886 | CRP | 1401 | 205753_at | -0.2017 | 0.0636 | |
| GSE29001 | CRP | 1401 | 205753_at | -0.0764 | 0.7527 | |
| GSE38129 | CRP | 1401 | 205753_at | -0.0018 | 0.9859 | |
| GSE45670 | CRP | 1401 | 205753_at | -0.0942 | 0.3821 | |
| GSE53622 | CRP | 1401 | 78275 | 0.2130 | 0.1064 | |
| GSE53624 | CRP | 1401 | 78275 | 0.1515 | 0.0386 | |
| GSE63941 | CRP | 1401 | 205753_at | 0.0719 | 0.5943 | |
| GSE77861 | CRP | 1401 | 37020_at | -0.0162 | 0.8953 | |
| TCGA | CRP | 1401 | RNAseq | 1.6410 | 0.1979 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRP | 1401 | 10 | 0 | 20 | |
| GSE20123 | CRP | 1401 | 10 | 0 | 20 | |
| GSE43470 | CRP | 1401 | 7 | 2 | 34 | |
| GSE46452 | CRP | 1401 | 2 | 1 | 56 | |
| GSE47630 | CRP | 1401 | 14 | 0 | 26 | |
| GSE54993 | CRP | 1401 | 0 | 5 | 65 | |
| GSE54994 | CRP | 1401 | 16 | 0 | 37 | |
| GSE60625 | CRP | 1401 | 0 | 0 | 11 | |
| GSE74703 | CRP | 1401 | 7 | 2 | 27 | |
| GSE74704 | CRP | 1401 | 4 | 0 | 16 | |
| TCGA | CRP | 1401 | 43 | 3 | 50 |
Total number of gains: 113; Total number of losses: 13; Total Number of normals: 362.
Somatic mutations of CRP:
Generating mutation plots.
Highly correlated genes for CRP:
Showing top 20/899 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRP | MEFV | 0.743308 | 3 | 0 | 3 |
| CRP | VGF | 0.743243 | 4 | 0 | 4 |
| CRP | DCC | 0.740512 | 4 | 0 | 4 |
| CRP | CPA2 | 0.724304 | 3 | 0 | 3 |
| CRP | CCDC30 | 0.722287 | 5 | 0 | 5 |
| CRP | CHRM5 | 0.712805 | 4 | 0 | 4 |
| CRP | FOXN3-AS2 | 0.71255 | 5 | 0 | 5 |
| CRP | SOX3 | 0.71057 | 3 | 0 | 3 |
| CRP | CRISP1 | 0.708137 | 4 | 0 | 4 |
| CRP | XPNPEP2 | 0.706937 | 3 | 0 | 3 |
| CRP | SERPINA2 | 0.705826 | 3 | 0 | 3 |
| CRP | IFNA14 | 0.70532 | 5 | 0 | 5 |
| CRP | SLC6A12 | 0.701488 | 5 | 0 | 5 |
| CRP | RNF17 | 0.697253 | 5 | 0 | 5 |
| CRP | IFNA7 | 0.696619 | 5 | 0 | 5 |
| CRP | CHRM2 | 0.696544 | 4 | 0 | 4 |
| CRP | AZU1 | 0.694138 | 3 | 0 | 3 |
| CRP | FSCN3 | 0.69151 | 6 | 0 | 6 |
| CRP | ZNF771 | 0.69143 | 3 | 0 | 3 |
| CRP | IFT122 | 0.690116 | 4 | 0 | 4 |
For details and further investigation, click here
