| Full name: DCC netrin 1 receptor | Alias Symbol: IGDCC1|NTN1R1 | ||
| Type: protein-coding gene | Cytoband: 18q21.2 | ||
| Entrez ID: 1630 | HGNC ID: HGNC:2701 | Ensembl Gene: ENSG00000187323 | OMIM ID: 120470 |
| Drug and gene relationship at DGIdb | |||
DCC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa05200 | Pathways in cancer | |
| hsa05210 | Colorectal cancer |
Expression of DCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCC | 1630 | 206939_at | -0.0131 | 0.9771 | |
| GSE20347 | DCC | 1630 | 206939_at | 0.0404 | 0.6619 | |
| GSE23400 | DCC | 1630 | 206939_at | -0.1821 | 0.0007 | |
| GSE26886 | DCC | 1630 | 242653_at | -0.0366 | 0.7605 | |
| GSE29001 | DCC | 1630 | 206939_at | -0.0372 | 0.8500 | |
| GSE38129 | DCC | 1630 | 206939_at | -0.0801 | 0.2361 | |
| GSE45670 | DCC | 1630 | 242653_at | 0.1398 | 0.0362 | |
| GSE53622 | DCC | 1630 | 79263 | 0.6138 | 0.0207 | |
| GSE53624 | DCC | 1630 | 79263 | 0.6819 | 0.0000 | |
| GSE63941 | DCC | 1630 | 206939_at | 0.0970 | 0.4639 | |
| GSE77861 | DCC | 1630 | 242653_at | -0.0301 | 0.8159 | |
| SRP133303 | DCC | 1630 | RNAseq | -0.2703 | 0.6749 | |
| TCGA | DCC | 1630 | RNAseq | 0.8942 | 0.3392 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCC | 1630 | 1 | 9 | 20 | |
| GSE20123 | DCC | 1630 | 1 | 9 | 20 | |
| GSE43470 | DCC | 1630 | 0 | 5 | 38 | |
| GSE46452 | DCC | 1630 | 1 | 26 | 32 | |
| GSE47630 | DCC | 1630 | 5 | 20 | 15 | |
| GSE54993 | DCC | 1630 | 9 | 0 | 61 | |
| GSE54994 | DCC | 1630 | 1 | 17 | 35 | |
| GSE60625 | DCC | 1630 | 0 | 4 | 7 | |
| GSE74703 | DCC | 1630 | 0 | 5 | 31 | |
| GSE74704 | DCC | 1630 | 1 | 6 | 13 | |
| TCGA | DCC | 1630 | 9 | 44 | 43 |
Total number of gains: 28; Total number of losses: 145; Total Number of normals: 315.
Somatic mutations of DCC:
Generating mutation plots.
Highly correlated genes for DCC:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCC | IL1RL1 | 0.769151 | 4 | 0 | 4 |
| DCC | CRP | 0.740512 | 4 | 0 | 4 |
| DCC | PRR34 | 0.729301 | 5 | 0 | 5 |
| DCC | RNF17 | 0.729211 | 4 | 0 | 4 |
| DCC | HECW1 | 0.718035 | 5 | 0 | 5 |
| DCC | INHA | 0.714545 | 3 | 0 | 3 |
| DCC | KRT76 | 0.705331 | 4 | 0 | 4 |
| DCC | NEUROD1 | 0.705024 | 4 | 0 | 4 |
| DCC | IL1RAPL2 | 0.702511 | 4 | 0 | 4 |
| DCC | IFNA10 | 0.700792 | 4 | 0 | 4 |
| DCC | LRRC75B | 0.699355 | 3 | 0 | 3 |
| DCC | AKAP5 | 0.696362 | 4 | 0 | 4 |
| DCC | C1orf68 | 0.693387 | 3 | 0 | 3 |
| DCC | FXYD7 | 0.692066 | 4 | 0 | 4 |
| DCC | IL18BP | 0.687584 | 5 | 0 | 5 |
| DCC | CABP5 | 0.686291 | 4 | 0 | 4 |
| DCC | SMR3A | 0.680153 | 4 | 0 | 4 |
| DCC | NNAT | 0.679816 | 5 | 0 | 5 |
| DCC | APOBEC1 | 0.677407 | 3 | 0 | 3 |
| DCC | SLC17A3 | 0.67546 | 5 | 0 | 5 |
For details and further investigation, click here
