| Full name: MEFV innate immuity regulator, pyrin | Alias Symbol: FMF|TRIM20 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 4210 | HGNC ID: HGNC:6998 | Ensembl Gene: ENSG00000103313 | OMIM ID: 608107 |
| Drug and gene relationship at DGIdb | |||
MEFV involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of MEFV:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEFV | 4210 | 208262_x_at | -0.0535 | 0.8687 | |
| GSE20347 | MEFV | 4210 | 208262_x_at | 0.0552 | 0.7375 | |
| GSE23400 | MEFV | 4210 | 208262_x_at | -0.0016 | 0.9643 | |
| GSE26886 | MEFV | 4210 | 208262_x_at | -0.0235 | 0.8535 | |
| GSE29001 | MEFV | 4210 | 208262_x_at | -0.0587 | 0.8135 | |
| GSE38129 | MEFV | 4210 | 208262_x_at | -0.0350 | 0.7884 | |
| GSE45670 | MEFV | 4210 | 208262_x_at | 0.1992 | 0.0127 | |
| GSE53622 | MEFV | 4210 | 100434 | 0.6777 | 0.0000 | |
| GSE53624 | MEFV | 4210 | 100434 | 0.5143 | 0.0000 | |
| GSE63941 | MEFV | 4210 | 208262_x_at | 0.7296 | 0.0000 | |
| GSE77861 | MEFV | 4210 | 208262_x_at | -0.0988 | 0.4634 | |
| GSE97050 | MEFV | 4210 | A_23_P140967 | 0.3903 | 0.1711 | |
| SRP133303 | MEFV | 4210 | RNAseq | 0.7524 | 0.0000 | |
| SRP193095 | MEFV | 4210 | RNAseq | 1.3774 | 0.0000 | |
| SRP219564 | MEFV | 4210 | RNAseq | 1.1183 | 0.0642 | |
| TCGA | MEFV | 4210 | RNAseq | 0.8285 | 0.0153 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MEFV expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEFV:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEFV | 4210 | 5 | 5 | 20 | |
| GSE20123 | MEFV | 4210 | 5 | 4 | 21 | |
| GSE43470 | MEFV | 4210 | 4 | 7 | 32 | |
| GSE46452 | MEFV | 4210 | 38 | 1 | 20 | |
| GSE47630 | MEFV | 4210 | 13 | 6 | 21 | |
| GSE54993 | MEFV | 4210 | 3 | 5 | 62 | |
| GSE54994 | MEFV | 4210 | 5 | 9 | 39 | |
| GSE60625 | MEFV | 4210 | 4 | 0 | 7 | |
| GSE74703 | MEFV | 4210 | 4 | 5 | 27 | |
| GSE74704 | MEFV | 4210 | 3 | 2 | 15 | |
| TCGA | MEFV | 4210 | 19 | 13 | 64 |
Total number of gains: 103; Total number of losses: 57; Total Number of normals: 328.
Somatic mutations of MEFV:
Generating mutation plots.
Highly correlated genes for MEFV:
Showing top 20/564 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEFV | ERN1 | 0.776908 | 3 | 0 | 3 |
| MEFV | MTAP | 0.755131 | 3 | 0 | 3 |
| MEFV | CRP | 0.743308 | 3 | 0 | 3 |
| MEFV | LRTM1 | 0.740131 | 3 | 0 | 3 |
| MEFV | DNMT3L | 0.729962 | 3 | 0 | 3 |
| MEFV | GK2 | 0.726032 | 3 | 0 | 3 |
| MEFV | SLC16A8 | 0.724938 | 3 | 0 | 3 |
| MEFV | RFPL3 | 0.724389 | 3 | 0 | 3 |
| MEFV | UTS2R | 0.72251 | 3 | 0 | 3 |
| MEFV | CAMKV | 0.718617 | 3 | 0 | 3 |
| MEFV | RNF17 | 0.717307 | 3 | 0 | 3 |
| MEFV | KCNA1 | 0.713931 | 4 | 0 | 4 |
| MEFV | CD22 | 0.697838 | 4 | 0 | 4 |
| MEFV | FCGR2C | 0.697128 | 5 | 0 | 5 |
| MEFV | CACNG3 | 0.695498 | 4 | 0 | 4 |
| MEFV | AQP8 | 0.69236 | 4 | 0 | 4 |
| MEFV | RFX2 | 0.690596 | 3 | 0 | 3 |
| MEFV | NAT2 | 0.68575 | 3 | 0 | 3 |
| MEFV | CYP1A2 | 0.68536 | 4 | 0 | 4 |
| MEFV | IFNA10 | 0.684459 | 3 | 0 | 3 |
For details and further investigation, click here
