| Full name: solute carrier family 6 member 12 | Alias Symbol: BGT-1 | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 6539 | HGNC ID: HGNC:11045 | Ensembl Gene: ENSG00000111181 | OMIM ID: 603080 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC6A12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A12 | 6539 | 206058_at | 0.0985 | 0.7318 | |
| GSE20347 | SLC6A12 | 6539 | 206058_at | 0.0790 | 0.4201 | |
| GSE23400 | SLC6A12 | 6539 | 206058_at | -0.1635 | 0.0000 | |
| GSE26886 | SLC6A12 | 6539 | 206058_at | 0.2177 | 0.0388 | |
| GSE29001 | SLC6A12 | 6539 | 206058_at | -0.0087 | 0.9604 | |
| GSE38129 | SLC6A12 | 6539 | 206058_at | 0.0014 | 0.9879 | |
| GSE45670 | SLC6A12 | 6539 | 206058_at | 0.0728 | 0.4023 | |
| GSE53622 | SLC6A12 | 6539 | 23356 | 0.6556 | 0.0000 | |
| GSE53624 | SLC6A12 | 6539 | 56862 | 1.5492 | 0.0000 | |
| GSE63941 | SLC6A12 | 6539 | 206058_at | 0.1653 | 0.3039 | |
| GSE77861 | SLC6A12 | 6539 | 206058_at | -0.0129 | 0.9146 | |
| SRP133303 | SLC6A12 | 6539 | RNAseq | 2.0274 | 0.0000 | |
| SRP219564 | SLC6A12 | 6539 | RNAseq | 3.0015 | 0.0001 | |
| TCGA | SLC6A12 | 6539 | RNAseq | -0.2268 | 0.5504 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SLC6A12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A12 | 6539 | 7 | 4 | 19 | |
| GSE20123 | SLC6A12 | 6539 | 7 | 4 | 19 | |
| GSE43470 | SLC6A12 | 6539 | 8 | 3 | 32 | |
| GSE46452 | SLC6A12 | 6539 | 10 | 1 | 48 | |
| GSE47630 | SLC6A12 | 6539 | 12 | 2 | 26 | |
| GSE54993 | SLC6A12 | 6539 | 1 | 10 | 59 | |
| GSE54994 | SLC6A12 | 6539 | 10 | 2 | 41 | |
| GSE60625 | SLC6A12 | 6539 | 0 | 1 | 10 | |
| GSE74703 | SLC6A12 | 6539 | 7 | 2 | 27 | |
| GSE74704 | SLC6A12 | 6539 | 4 | 2 | 14 | |
| TCGA | SLC6A12 | 6539 | 41 | 7 | 48 |
Total number of gains: 107; Total number of losses: 38; Total Number of normals: 343.
Somatic mutations of SLC6A12:
Generating mutation plots.
Highly correlated genes for SLC6A12:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A12 | CYSLTR2 | 0.744775 | 4 | 0 | 4 |
| SLC6A12 | MAS1 | 0.734569 | 5 | 0 | 5 |
| SLC6A12 | LCT | 0.725315 | 4 | 0 | 4 |
| SLC6A12 | KCNA1 | 0.724887 | 4 | 0 | 4 |
| SLC6A12 | SYT13 | 0.719756 | 4 | 0 | 3 |
| SLC6A12 | RPH3A | 0.711133 | 3 | 0 | 3 |
| SLC6A12 | CBL | 0.708201 | 4 | 0 | 4 |
| SLC6A12 | PPP1R3A | 0.706143 | 5 | 0 | 5 |
| SLC6A12 | OR52A1 | 0.70394 | 4 | 0 | 4 |
| SLC6A12 | MTAP | 0.702451 | 4 | 0 | 4 |
| SLC6A12 | CRP | 0.701488 | 5 | 0 | 5 |
| SLC6A12 | PRLR | 0.700351 | 4 | 0 | 4 |
| SLC6A12 | DNAH9 | 0.695521 | 6 | 0 | 6 |
| SLC6A12 | ZNF460 | 0.693632 | 4 | 0 | 4 |
| SLC6A12 | TRHR | 0.693056 | 4 | 0 | 4 |
| SLC6A12 | OR7C2 | 0.691653 | 5 | 0 | 5 |
| SLC6A12 | CYP2A7 | 0.691432 | 5 | 0 | 4 |
| SLC6A12 | ADAM21 | 0.691395 | 4 | 0 | 4 |
| SLC6A12 | LMAN1L | 0.69099 | 4 | 0 | 4 |
| SLC6A12 | RNF185-AS1 | 0.687895 | 5 | 0 | 4 |
For details and further investigation, click here
