IFNA14

 

Full name: interferon alpha 14 Alias Symbol: LEIF2H|IFN-alphaH
Type: protein-coding gene Cytoband: 9p21.3
Entrez ID: 3448 HGNC ID: HGNC:5420 Ensembl Gene: ENSG00000228083 OMIM ID: 147579
Drug and gene relationship at DGIdb

 

IFNA14 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles

 

Expression of IFNA14:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNA14 3448 208182_x_at -0.0203 0.9529
GSE20347 IFNA14 3448 208182_x_at 0.0463 0.5995
GSE23400 IFNA14 3448 208182_x_at -0.1941 0.0002
GSE26886 IFNA14 3448 208182_x_at -0.2088 0.0092
GSE29001 IFNA14 3448 208182_x_at -0.1219 0.4876
GSE38129 IFNA14 3448 208182_x_at -0.0609 0.4522
GSE45670 IFNA14 3448 208182_x_at 0.0608 0.5059
GSE53622 IFNA14 3448 118593 -0.0434 0.8492
GSE53624 IFNA14 3448 118593 0.0406 0.7258
GSE63941 IFNA14 3448 208182_x_at -0.1932 0.1381
GSE77861 IFNA14 3448 208182_x_at -0.2063 0.0781

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IFNA14 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNA14:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNA14 3448 2 17 11
GSE20123 IFNA14 3448 2 17 11
GSE43470 IFNA14 3448 4 13 26
GSE46452 IFNA14 3448 2 23 34
GSE47630 IFNA14 3448 3 27 10
GSE54993 IFNA14 3448 7 2 61
GSE54994 IFNA14 3448 8 16 29
GSE60625 IFNA14 3448 3 0 8
GSE74703 IFNA14 3448 4 10 22
GSE74704 IFNA14 3448 0 13 7
TCGA IFNA14 3448 11 53 32

Total number of gains: 46; Total number of losses: 191; Total Number of normals: 251.  

 

Somatic mutations of IFNA14:

 

Generating mutation plots.

 

Highly correlated genes for IFNA14:

 

Showing top 20/755 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNA14MTAP0.747893404
IFNA14FOXN3-AS20.744643505
IFNA14CHAT0.733888404
IFNA14C1orf680.725038303
IFNA14FOLH10.724884505
IFNA14NTNG10.719356404
IFNA14CRP0.70532505
IFNA14GRM10.69973404
IFNA14CCR90.698798404
IFNA14NCR10.69765404
IFNA14MTTP0.696716303
IFNA14RNF170.695654505
IFNA14CPA20.690062404
IFNA14OR2J20.686909604
IFNA14UMOD0.683352505
IFNA14KRTAP5-80.682798606
IFNA14CCZ10.682545404
IFNA14NEUROD20.681223403
IFNA14CCL160.679212403
IFNA14IL17A0.678827504

For details and further investigation, click here