| Full name: colony stimulating factor 3 | Alias Symbol: MGC45931 | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 1440 | HGNC ID: HGNC:2438 | Ensembl Gene: ENSG00000108342 | OMIM ID: 138970 |
| Drug and gene relationship at DGIdb | |||
CSF3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of CSF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSF3 | 1440 | 207442_at | 0.3629 | 0.7599 | |
| GSE20347 | CSF3 | 1440 | 207442_at | -0.0674 | 0.5042 | |
| GSE23400 | CSF3 | 1440 | 207442_at | -0.1719 | 0.0065 | |
| GSE26886 | CSF3 | 1440 | 207442_at | 0.2378 | 0.1031 | |
| GSE29001 | CSF3 | 1440 | 207442_at | -0.1757 | 0.2037 | |
| GSE38129 | CSF3 | 1440 | 207442_at | -0.2406 | 0.1770 | |
| GSE45670 | CSF3 | 1440 | 207442_at | 0.0279 | 0.9074 | |
| GSE53622 | CSF3 | 1440 | 50939 | 0.1960 | 0.5671 | |
| GSE53624 | CSF3 | 1440 | 50939 | 0.0542 | 0.8084 | |
| GSE63941 | CSF3 | 1440 | 207442_at | 0.0726 | 0.6070 | |
| GSE77861 | CSF3 | 1440 | 207442_at | -0.1225 | 0.3582 | |
| GSE97050 | CSF3 | 1440 | A_33_P3222424 | 0.5358 | 0.4348 | |
| SRP159526 | CSF3 | 1440 | RNAseq | 0.9711 | 0.2451 | |
| SRP219564 | CSF3 | 1440 | RNAseq | 0.6308 | 0.4759 | |
| TCGA | CSF3 | 1440 | RNAseq | 0.2186 | 0.6187 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CSF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSF3 | 1440 | 9 | 1 | 20 | |
| GSE20123 | CSF3 | 1440 | 9 | 1 | 20 | |
| GSE43470 | CSF3 | 1440 | 1 | 2 | 40 | |
| GSE46452 | CSF3 | 1440 | 34 | 0 | 25 | |
| GSE47630 | CSF3 | 1440 | 8 | 1 | 31 | |
| GSE54993 | CSF3 | 1440 | 3 | 4 | 63 | |
| GSE54994 | CSF3 | 1440 | 9 | 5 | 39 | |
| GSE60625 | CSF3 | 1440 | 4 | 0 | 7 | |
| GSE74703 | CSF3 | 1440 | 1 | 1 | 34 | |
| GSE74704 | CSF3 | 1440 | 5 | 1 | 14 | |
| TCGA | CSF3 | 1440 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 24; Total Number of normals: 358.
Somatic mutations of CSF3:
Generating mutation plots.
Highly correlated genes for CSF3:
Showing top 20/160 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSF3 | LINC00598 | 0.710481 | 4 | 0 | 4 |
| CSF3 | GRP | 0.708713 | 3 | 0 | 3 |
| CSF3 | EVA1B | 0.70037 | 4 | 0 | 3 |
| CSF3 | LINC00475 | 0.693801 | 3 | 0 | 3 |
| CSF3 | RIMS4 | 0.667289 | 4 | 0 | 3 |
| CSF3 | AMER3 | 0.664998 | 3 | 0 | 3 |
| CSF3 | HDAC10 | 0.664673 | 3 | 0 | 3 |
| CSF3 | NFE4 | 0.66215 | 3 | 0 | 3 |
| CSF3 | SEZ6L2 | 0.660189 | 4 | 0 | 3 |
| CSF3 | ASPDH | 0.654541 | 3 | 0 | 3 |
| CSF3 | FIBCD1 | 0.644967 | 4 | 0 | 3 |
| CSF3 | PPP1R3F | 0.643536 | 3 | 0 | 3 |
| CSF3 | TTC9B | 0.638051 | 4 | 0 | 3 |
| CSF3 | LIM2 | 0.634759 | 4 | 0 | 3 |
| CSF3 | XKR7 | 0.62847 | 4 | 0 | 3 |
| CSF3 | KCND3 | 0.626966 | 3 | 0 | 3 |
| CSF3 | ADAMTS14 | 0.625005 | 3 | 0 | 3 |
| CSF3 | C9orf131 | 0.623463 | 4 | 0 | 3 |
| CSF3 | SCUBE1 | 0.615752 | 4 | 0 | 3 |
| CSF3 | OVCH1-AS1 | 0.610028 | 3 | 0 | 3 |
For details and further investigation, click here
