| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 14 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 140766 | HGNC ID: HGNC:14899 | Ensembl Gene: ENSG00000138316 | OMIM ID: 607506 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS14 | 140766 | 230167_at | 0.2863 | 0.3004 | |
| GSE26886 | ADAMTS14 | 140766 | 230167_at | 0.2675 | 0.0407 | |
| GSE45670 | ADAMTS14 | 140766 | 230167_at | 0.2817 | 0.0013 | |
| GSE63941 | ADAMTS14 | 140766 | 230167_at | -0.1650 | 0.2902 | |
| GSE77861 | ADAMTS14 | 140766 | 230167_at | -0.1251 | 0.4615 | |
| GSE97050 | ADAMTS14 | 140766 | A_24_P275073 | 1.0259 | 0.1156 | |
| SRP007169 | ADAMTS14 | 140766 | RNAseq | 1.4694 | 0.0436 | |
| SRP064894 | ADAMTS14 | 140766 | RNAseq | 2.8185 | 0.0000 | |
| SRP133303 | ADAMTS14 | 140766 | RNAseq | 2.8121 | 0.0000 | |
| SRP159526 | ADAMTS14 | 140766 | RNAseq | 1.5216 | 0.0010 | |
| SRP193095 | ADAMTS14 | 140766 | RNAseq | 2.3774 | 0.0000 | |
| SRP219564 | ADAMTS14 | 140766 | RNAseq | 2.8270 | 0.0000 | |
| TCGA | ADAMTS14 | 140766 | RNAseq | 0.8521 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by ADAMTS14 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS14 | 140766 | 2 | 4 | 24 | |
| GSE20123 | ADAMTS14 | 140766 | 2 | 3 | 25 | |
| GSE43470 | ADAMTS14 | 140766 | 1 | 7 | 35 | |
| GSE46452 | ADAMTS14 | 140766 | 0 | 11 | 48 | |
| GSE47630 | ADAMTS14 | 140766 | 2 | 14 | 24 | |
| GSE54993 | ADAMTS14 | 140766 | 7 | 0 | 63 | |
| GSE54994 | ADAMTS14 | 140766 | 2 | 11 | 40 | |
| GSE60625 | ADAMTS14 | 140766 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS14 | 140766 | 1 | 4 | 31 | |
| GSE74704 | ADAMTS14 | 140766 | 1 | 1 | 18 | |
| TCGA | ADAMTS14 | 140766 | 10 | 24 | 62 |
Total number of gains: 28; Total number of losses: 79; Total Number of normals: 381.
Somatic mutations of ADAMTS14:
Generating mutation plots.
Highly correlated genes for ADAMTS14:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS14 | FSCN1 | 0.758087 | 4 | 0 | 4 |
| ADAMTS14 | AJUBA | 0.756482 | 3 | 0 | 3 |
| ADAMTS14 | TMSB10 | 0.741185 | 4 | 0 | 4 |
| ADAMTS14 | TNS4 | 0.727485 | 4 | 0 | 4 |
| ADAMTS14 | MPHOSPH6 | 0.718032 | 3 | 0 | 3 |
| ADAMTS14 | SLC16A10 | 0.717229 | 3 | 0 | 3 |
| ADAMTS14 | S100A7A | 0.716995 | 3 | 0 | 3 |
| ADAMTS14 | C11orf24 | 0.706359 | 3 | 0 | 3 |
| ADAMTS14 | SERPINE1 | 0.699925 | 4 | 0 | 3 |
| ADAMTS14 | SNX29 | 0.698032 | 3 | 0 | 3 |
| ADAMTS14 | NRG1 | 0.696239 | 4 | 0 | 4 |
| ADAMTS14 | BMP1 | 0.696182 | 4 | 0 | 4 |
| ADAMTS14 | GPC1 | 0.693487 | 3 | 0 | 3 |
| ADAMTS14 | NMB | 0.690067 | 4 | 0 | 4 |
| ADAMTS14 | SLC7A8 | 0.688628 | 3 | 0 | 3 |
| ADAMTS14 | EIF2AK1 | 0.688174 | 3 | 0 | 3 |
| ADAMTS14 | DOK1 | 0.68813 | 3 | 0 | 3 |
| ADAMTS14 | ERVMER34-1 | 0.684172 | 3 | 0 | 3 |
| ADAMTS14 | TTYH3 | 0.684072 | 4 | 0 | 4 |
| ADAMTS14 | COL22A1 | 0.681594 | 3 | 0 | 3 |
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