| Full name: signal peptide, CUB domain and EGF like domain containing 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 80274 | HGNC ID: HGNC:13441 | Ensembl Gene: ENSG00000159307 | OMIM ID: 611746 |
| Drug and gene relationship at DGIdb | |||
Expression of SCUBE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCUBE1 | 80274 | 233988_x_at | 0.0993 | 0.7511 | |
| GSE26886 | SCUBE1 | 80274 | 233988_x_at | 0.5060 | 0.0001 | |
| GSE45670 | SCUBE1 | 80274 | 233988_x_at | -0.0318 | 0.7693 | |
| GSE53622 | SCUBE1 | 80274 | 29457 | 0.0401 | 0.6714 | |
| GSE53624 | SCUBE1 | 80274 | 29457 | 0.1957 | 0.0680 | |
| GSE63941 | SCUBE1 | 80274 | 233988_x_at | 0.1723 | 0.1153 | |
| GSE77861 | SCUBE1 | 80274 | 233988_x_at | 0.0577 | 0.7354 | |
| GSE97050 | SCUBE1 | 80274 | A_33_P3417487 | -0.2800 | 0.3632 | |
| SRP064894 | SCUBE1 | 80274 | RNAseq | -0.7317 | 0.1078 | |
| SRP133303 | SCUBE1 | 80274 | RNAseq | -0.9019 | 0.1685 | |
| SRP159526 | SCUBE1 | 80274 | RNAseq | -3.1064 | 0.0000 | |
| SRP193095 | SCUBE1 | 80274 | RNAseq | -0.4292 | 0.0763 | |
| TCGA | SCUBE1 | 80274 | RNAseq | -1.5824 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SCUBE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCUBE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCUBE1 | 80274 | 5 | 7 | 18 | |
| GSE20123 | SCUBE1 | 80274 | 5 | 6 | 19 | |
| GSE43470 | SCUBE1 | 80274 | 3 | 6 | 34 | |
| GSE46452 | SCUBE1 | 80274 | 31 | 2 | 26 | |
| GSE47630 | SCUBE1 | 80274 | 9 | 4 | 27 | |
| GSE54993 | SCUBE1 | 80274 | 3 | 6 | 61 | |
| GSE54994 | SCUBE1 | 80274 | 11 | 8 | 34 | |
| GSE60625 | SCUBE1 | 80274 | 5 | 0 | 6 | |
| GSE74703 | SCUBE1 | 80274 | 3 | 4 | 29 | |
| GSE74704 | SCUBE1 | 80274 | 2 | 3 | 15 | |
| TCGA | SCUBE1 | 80274 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of SCUBE1:
Generating mutation plots.
Highly correlated genes for SCUBE1:
Showing top 20/431 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCUBE1 | TM6SF2 | 0.802712 | 3 | 0 | 3 |
| SCUBE1 | CPAMD8 | 0.797038 | 3 | 0 | 3 |
| SCUBE1 | TTC9B | 0.781498 | 3 | 0 | 3 |
| SCUBE1 | ZNF428 | 0.770502 | 3 | 0 | 3 |
| SCUBE1 | CACNA1A | 0.765897 | 3 | 0 | 3 |
| SCUBE1 | RPP25 | 0.756794 | 3 | 0 | 3 |
| SCUBE1 | IGFALS | 0.754828 | 5 | 0 | 5 |
| SCUBE1 | TMEM151B | 0.734401 | 3 | 0 | 3 |
| SCUBE1 | ARVCF | 0.731484 | 5 | 0 | 4 |
| SCUBE1 | ZNF446 | 0.72907 | 3 | 0 | 3 |
| SCUBE1 | LINC00598 | 0.726215 | 3 | 0 | 3 |
| SCUBE1 | CLSTN3 | 0.724353 | 4 | 0 | 4 |
| SCUBE1 | STMN4 | 0.720943 | 3 | 0 | 3 |
| SCUBE1 | SLC4A1 | 0.720448 | 3 | 0 | 3 |
| SCUBE1 | L3MBTL1 | 0.72017 | 4 | 0 | 3 |
| SCUBE1 | ZNF646 | 0.720058 | 5 | 0 | 5 |
| SCUBE1 | SDHAF1 | 0.715554 | 3 | 0 | 3 |
| SCUBE1 | SYCE1L | 0.71349 | 3 | 0 | 3 |
| SCUBE1 | FAM186B | 0.70309 | 4 | 0 | 4 |
| SCUBE1 | DOHH | 0.702842 | 4 | 0 | 3 |
For details and further investigation, click here
