| Full name: cathepsin O | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q32.1 | ||
| Entrez ID: 1519 | HGNC ID: HGNC:2542 | Ensembl Gene: ENSG00000256043 | OMIM ID: 600550 |
| Drug and gene relationship at DGIdb | |||
CTSO involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of CTSO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTSO | 1519 | 203758_at | -0.6255 | 0.5842 | |
| GSE20347 | CTSO | 1519 | 203758_at | -0.2160 | 0.3154 | |
| GSE23400 | CTSO | 1519 | 203758_at | 0.0075 | 0.9430 | |
| GSE26886 | CTSO | 1519 | 203758_at | -0.2111 | 0.6556 | |
| GSE29001 | CTSO | 1519 | 203758_at | 0.1376 | 0.6474 | |
| GSE38129 | CTSO | 1519 | 203758_at | -0.4152 | 0.2223 | |
| GSE45670 | CTSO | 1519 | 203758_at | -1.1239 | 0.0005 | |
| GSE53622 | CTSO | 1519 | 11892 | -0.5537 | 0.0000 | |
| GSE53624 | CTSO | 1519 | 11892 | -0.1339 | 0.2873 | |
| GSE63941 | CTSO | 1519 | 203758_at | -3.2720 | 0.0001 | |
| GSE77861 | CTSO | 1519 | 203758_at | 0.1185 | 0.6826 | |
| GSE97050 | CTSO | 1519 | A_33_P3418025 | -0.5337 | 0.1482 | |
| SRP007169 | CTSO | 1519 | RNAseq | 0.4879 | 0.3785 | |
| SRP008496 | CTSO | 1519 | RNAseq | 0.9932 | 0.0057 | |
| SRP064894 | CTSO | 1519 | RNAseq | 0.2808 | 0.3211 | |
| SRP133303 | CTSO | 1519 | RNAseq | 0.3768 | 0.1372 | |
| SRP159526 | CTSO | 1519 | RNAseq | 0.0611 | 0.8677 | |
| SRP193095 | CTSO | 1519 | RNAseq | -0.2364 | 0.3461 | |
| SRP219564 | CTSO | 1519 | RNAseq | 0.5167 | 0.4486 | |
| TCGA | CTSO | 1519 | RNAseq | -0.2917 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CTSO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CTSO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTSO | 1519 | 0 | 14 | 16 | |
| GSE20123 | CTSO | 1519 | 0 | 14 | 16 | |
| GSE43470 | CTSO | 1519 | 0 | 14 | 29 | |
| GSE46452 | CTSO | 1519 | 1 | 36 | 22 | |
| GSE47630 | CTSO | 1519 | 0 | 23 | 17 | |
| GSE54993 | CTSO | 1519 | 10 | 0 | 60 | |
| GSE54994 | CTSO | 1519 | 1 | 12 | 40 | |
| GSE60625 | CTSO | 1519 | 0 | 1 | 10 | |
| GSE74703 | CTSO | 1519 | 0 | 12 | 24 | |
| GSE74704 | CTSO | 1519 | 0 | 7 | 13 | |
| TCGA | CTSO | 1519 | 10 | 36 | 50 |
Total number of gains: 22; Total number of losses: 169; Total Number of normals: 297.
Somatic mutations of CTSO:
Generating mutation plots.
Highly correlated genes for CTSO:
Showing top 20/1216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTSO | AFF3 | 0.864899 | 3 | 0 | 3 |
| CTSO | FIBIN | 0.804415 | 4 | 0 | 4 |
| CTSO | CACNA2D4 | 0.791638 | 3 | 0 | 3 |
| CTSO | GIMAP5 | 0.779304 | 3 | 0 | 3 |
| CTSO | TCEAL6 | 0.764412 | 3 | 0 | 3 |
| CTSO | LRRN4CL | 0.753523 | 7 | 0 | 6 |
| CTSO | SEC22C | 0.752473 | 5 | 0 | 5 |
| CTSO | USP9Y | 0.751582 | 3 | 0 | 3 |
| CTSO | MBD5 | 0.750451 | 3 | 0 | 3 |
| CTSO | OLFML1 | 0.749281 | 10 | 0 | 10 |
| CTSO | UBE2R2 | 0.743835 | 3 | 0 | 3 |
| CTSO | CCDC80 | 0.734651 | 7 | 0 | 6 |
| CTSO | NR2F1 | 0.731994 | 3 | 0 | 3 |
| CTSO | C11orf96 | 0.731993 | 4 | 0 | 4 |
| CTSO | CNRIP1 | 0.728775 | 8 | 0 | 7 |
| CTSO | TCF21 | 0.723845 | 9 | 0 | 8 |
| CTSO | TCEAL5 | 0.721752 | 3 | 0 | 3 |
| CTSO | NAP1L3 | 0.721672 | 8 | 0 | 8 |
| CTSO | FGF7 | 0.72148 | 8 | 0 | 8 |
| CTSO | MAP4 | 0.719879 | 4 | 0 | 3 |
For details and further investigation, click here
