| Full name: transcription factor 21 | Alias Symbol: POD1|bHLHa23 | ||
| Type: protein-coding gene | Cytoband: 6q23.2 | ||
| Entrez ID: 6943 | HGNC ID: HGNC:11632 | Ensembl Gene: ENSG00000118526 | OMIM ID: 603306 |
| Drug and gene relationship at DGIdb | |||
Expression of TCF21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCF21 | 6943 | 204931_at | -2.0883 | 0.0343 | |
| GSE20347 | TCF21 | 6943 | 204931_at | -0.3467 | 0.0115 | |
| GSE23400 | TCF21 | 6943 | 204931_at | -0.3832 | 0.0000 | |
| GSE26886 | TCF21 | 6943 | 229529_at | 0.0248 | 0.8903 | |
| GSE29001 | TCF21 | 6943 | 204931_at | -0.4923 | 0.0126 | |
| GSE38129 | TCF21 | 6943 | 204931_at | -0.9793 | 0.0120 | |
| GSE45670 | TCF21 | 6943 | 204931_at | -2.7022 | 0.0000 | |
| GSE53622 | TCF21 | 6943 | 72447 | -2.1556 | 0.0000 | |
| GSE53624 | TCF21 | 6943 | 72447 | -2.1037 | 0.0000 | |
| GSE63941 | TCF21 | 6943 | 229529_at | -6.8091 | 0.0000 | |
| GSE77861 | TCF21 | 6943 | 229529_at | 0.0072 | 0.9519 | |
| GSE97050 | TCF21 | 6943 | A_23_P156890 | -1.3472 | 0.0750 | |
| SRP007169 | TCF21 | 6943 | RNAseq | 0.1164 | 0.8680 | |
| SRP064894 | TCF21 | 6943 | RNAseq | -1.5664 | 0.0000 | |
| SRP133303 | TCF21 | 6943 | RNAseq | -1.8781 | 0.0000 | |
| SRP159526 | TCF21 | 6943 | RNAseq | -1.1728 | 0.0007 | |
| SRP219564 | TCF21 | 6943 | RNAseq | -0.8233 | 0.3351 | |
| TCGA | TCF21 | 6943 | RNAseq | -1.1354 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by TCF21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCF21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCF21 | 6943 | 3 | 4 | 23 | |
| GSE20123 | TCF21 | 6943 | 4 | 3 | 23 | |
| GSE43470 | TCF21 | 6943 | 5 | 0 | 38 | |
| GSE46452 | TCF21 | 6943 | 3 | 10 | 46 | |
| GSE47630 | TCF21 | 6943 | 9 | 4 | 27 | |
| GSE54993 | TCF21 | 6943 | 3 | 2 | 65 | |
| GSE54994 | TCF21 | 6943 | 9 | 7 | 37 | |
| GSE60625 | TCF21 | 6943 | 0 | 1 | 10 | |
| GSE74703 | TCF21 | 6943 | 4 | 0 | 32 | |
| GSE74704 | TCF21 | 6943 | 1 | 1 | 18 | |
| TCGA | TCF21 | 6943 | 11 | 18 | 67 |
Total number of gains: 52; Total number of losses: 50; Total Number of normals: 386.
Somatic mutations of TCF21:
Generating mutation plots.
Highly correlated genes for TCF21:
Showing top 20/1513 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCF21 | AFF3 | 0.918102 | 3 | 0 | 3 |
| TCF21 | LINC01082 | 0.892922 | 5 | 0 | 5 |
| TCF21 | FAM13C | 0.86102 | 4 | 0 | 4 |
| TCF21 | MAGI2-AS3 | 0.851445 | 6 | 0 | 6 |
| TCF21 | C1QTNF7 | 0.851115 | 5 | 0 | 5 |
| TCF21 | MFAP4 | 0.836633 | 11 | 0 | 11 |
| TCF21 | CLEC3B | 0.828453 | 3 | 0 | 3 |
| TCF21 | ARHGAP6 | 0.82577 | 10 | 0 | 10 |
| TCF21 | NR2F1 | 0.82369 | 3 | 0 | 3 |
| TCF21 | RCAN2 | 0.820424 | 12 | 0 | 12 |
| TCF21 | TMEM100 | 0.817905 | 10 | 0 | 9 |
| TCF21 | FENDRR | 0.817736 | 5 | 0 | 5 |
| TCF21 | SLC4A4 | 0.81637 | 6 | 0 | 6 |
| TCF21 | MRVI1 | 0.815501 | 7 | 0 | 7 |
| TCF21 | LRRN4CL | 0.81114 | 8 | 0 | 7 |
| TCF21 | ANGPTL1 | 0.811026 | 6 | 0 | 6 |
| TCF21 | LINC01279 | 0.810956 | 4 | 0 | 4 |
| TCF21 | SYNPO2 | 0.804433 | 6 | 0 | 6 |
| TCF21 | PGM5-AS1 | 0.803878 | 3 | 0 | 3 |
| TCF21 | RSPO2 | 0.803209 | 3 | 0 | 3 |
For details and further investigation, click here
