| Full name: C-X3-C motif chemokine ligand 1 | Alias Symbol: NTN|C3Xkine|ABCD-3|CXC3C|CXC3|fractalkine|neurotactin | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 6376 | HGNC ID: HGNC:10647 | Ensembl Gene: ENSG00000006210 | OMIM ID: 601880 |
| Drug and gene relationship at DGIdb | |||
CX3CL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CX3CL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CX3CL1 | 6376 | 823_at | 0.0662 | 0.9714 | |
| GSE20347 | CX3CL1 | 6376 | 823_at | 0.4435 | 0.1552 | |
| GSE23400 | CX3CL1 | 6376 | 203687_at | 0.0452 | 0.7306 | |
| GSE26886 | CX3CL1 | 6376 | 823_at | 1.0449 | 0.0303 | |
| GSE29001 | CX3CL1 | 6376 | 823_at | 0.1176 | 0.7467 | |
| GSE38129 | CX3CL1 | 6376 | 823_at | 0.2247 | 0.5008 | |
| GSE45670 | CX3CL1 | 6376 | 823_at | -0.3528 | 0.4494 | |
| GSE53622 | CX3CL1 | 6376 | 23777 | -0.2496 | 0.1175 | |
| GSE53624 | CX3CL1 | 6376 | 23777 | 0.0003 | 0.9978 | |
| GSE63941 | CX3CL1 | 6376 | 203687_at | 0.4447 | 0.4380 | |
| GSE77861 | CX3CL1 | 6376 | 203687_at | 0.1197 | 0.6240 | |
| GSE97050 | CX3CL1 | 6376 | A_24_P390495 | -0.3983 | 0.3366 | |
| SRP007169 | CX3CL1 | 6376 | RNAseq | 2.9052 | 0.0000 | |
| SRP064894 | CX3CL1 | 6376 | RNAseq | 0.1873 | 0.5999 | |
| SRP133303 | CX3CL1 | 6376 | RNAseq | 0.1529 | 0.7009 | |
| SRP159526 | CX3CL1 | 6376 | RNAseq | 1.0525 | 0.0669 | |
| SRP193095 | CX3CL1 | 6376 | RNAseq | 1.0485 | 0.0002 | |
| SRP219564 | CX3CL1 | 6376 | RNAseq | 1.5418 | 0.0517 | |
| TCGA | CX3CL1 | 6376 | RNAseq | 0.1144 | 0.4899 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CX3CL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CX3CL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CX3CL1 | 6376 | 6 | 0 | 24 | |
| GSE20123 | CX3CL1 | 6376 | 6 | 1 | 23 | |
| GSE43470 | CX3CL1 | 6376 | 3 | 6 | 34 | |
| GSE46452 | CX3CL1 | 6376 | 38 | 1 | 20 | |
| GSE47630 | CX3CL1 | 6376 | 10 | 8 | 22 | |
| GSE54993 | CX3CL1 | 6376 | 2 | 4 | 64 | |
| GSE54994 | CX3CL1 | 6376 | 7 | 10 | 36 | |
| GSE60625 | CX3CL1 | 6376 | 4 | 0 | 7 | |
| GSE74703 | CX3CL1 | 6376 | 3 | 3 | 30 | |
| GSE74704 | CX3CL1 | 6376 | 5 | 0 | 15 | |
| TCGA | CX3CL1 | 6376 | 26 | 12 | 58 |
Total number of gains: 110; Total number of losses: 45; Total Number of normals: 333.
Somatic mutations of CX3CL1:
Generating mutation plots.
Highly correlated genes for CX3CL1:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CX3CL1 | SLC35F1 | 0.658851 | 3 | 0 | 3 |
| CX3CL1 | CEBPD | 0.657748 | 3 | 0 | 3 |
| CX3CL1 | TSPYL5 | 0.642457 | 4 | 0 | 3 |
| CX3CL1 | RAD51C | 0.631322 | 4 | 0 | 4 |
| CX3CL1 | CORO6 | 0.631033 | 3 | 0 | 3 |
| CX3CL1 | SMG9 | 0.627179 | 4 | 0 | 4 |
| CX3CL1 | TCTN1 | 0.622387 | 5 | 0 | 4 |
| CX3CL1 | PELI3 | 0.613783 | 4 | 0 | 4 |
| CX3CL1 | SLC25A6 | 0.609869 | 3 | 0 | 3 |
| CX3CL1 | STOX1 | 0.609296 | 5 | 0 | 4 |
| CX3CL1 | REM1 | 0.605111 | 3 | 0 | 3 |
| CX3CL1 | SRF | 0.603586 | 3 | 0 | 3 |
| CX3CL1 | KLF12 | 0.60311 | 4 | 0 | 3 |
| CX3CL1 | ZBTB38 | 0.602142 | 3 | 0 | 3 |
| CX3CL1 | CUEDC2 | 0.60098 | 8 | 0 | 5 |
| CX3CL1 | DAP | 0.596994 | 4 | 0 | 4 |
| CX3CL1 | TMEM71 | 0.596744 | 4 | 0 | 3 |
| CX3CL1 | MYEF2 | 0.592932 | 4 | 0 | 3 |
| CX3CL1 | C15orf65 | 0.591507 | 3 | 0 | 3 |
| CX3CL1 | ZBTB40 | 0.590986 | 4 | 0 | 3 |
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