| Full name: serum response factor | Alias Symbol: MCM1 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 6722 | HGNC ID: HGNC:11291 | Ensembl Gene: ENSG00000112658 | OMIM ID: 600589 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SRF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway |
Expression of SRF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRF | 6722 | 202401_s_at | 0.2506 | 0.7321 | |
| GSE20347 | SRF | 6722 | 202401_s_at | 0.0186 | 0.9247 | |
| GSE23400 | SRF | 6722 | 202401_s_at | -0.2878 | 0.0013 | |
| GSE26886 | SRF | 6722 | 202401_s_at | 0.1393 | 0.5095 | |
| GSE29001 | SRF | 6722 | 202401_s_at | 0.0378 | 0.9090 | |
| GSE38129 | SRF | 6722 | 202401_s_at | -0.1919 | 0.3546 | |
| GSE45670 | SRF | 6722 | 202401_s_at | -0.4155 | 0.0009 | |
| GSE53622 | SRF | 6722 | 66392 | -0.0952 | 0.1710 | |
| GSE53624 | SRF | 6722 | 101676 | -0.2233 | 0.0004 | |
| GSE63941 | SRF | 6722 | 202401_s_at | 0.3667 | 0.2511 | |
| GSE77861 | SRF | 6722 | 202401_s_at | 0.1330 | 0.3486 | |
| GSE97050 | SRF | 6722 | A_24_P337657 | -0.9063 | 0.1072 | |
| SRP007169 | SRF | 6722 | RNAseq | 0.6938 | 0.1042 | |
| SRP008496 | SRF | 6722 | RNAseq | 0.9317 | 0.0050 | |
| SRP064894 | SRF | 6722 | RNAseq | -0.2257 | 0.2665 | |
| SRP133303 | SRF | 6722 | RNAseq | -0.1511 | 0.4813 | |
| SRP159526 | SRF | 6722 | RNAseq | -0.0054 | 0.9854 | |
| SRP193095 | SRF | 6722 | RNAseq | 0.2170 | 0.1498 | |
| SRP219564 | SRF | 6722 | RNAseq | -0.4936 | 0.4566 | |
| TCGA | SRF | 6722 | RNAseq | -0.0796 | 0.1208 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRF | 6722 | 7 | 0 | 23 | |
| GSE20123 | SRF | 6722 | 7 | 0 | 23 | |
| GSE43470 | SRF | 6722 | 6 | 0 | 37 | |
| GSE46452 | SRF | 6722 | 2 | 9 | 48 | |
| GSE47630 | SRF | 6722 | 8 | 4 | 28 | |
| GSE54993 | SRF | 6722 | 3 | 2 | 65 | |
| GSE54994 | SRF | 6722 | 11 | 4 | 38 | |
| GSE60625 | SRF | 6722 | 0 | 1 | 10 | |
| GSE74703 | SRF | 6722 | 6 | 0 | 30 | |
| GSE74704 | SRF | 6722 | 3 | 0 | 17 | |
| TCGA | SRF | 6722 | 21 | 13 | 62 |
Total number of gains: 74; Total number of losses: 33; Total Number of normals: 381.
Somatic mutations of SRF:
Generating mutation plots.
Highly correlated genes for SRF:
Showing top 20/491 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRF | CYP2U1 | 0.72801 | 3 | 0 | 3 |
| SRF | CTXN1 | 0.703951 | 3 | 0 | 3 |
| SRF | ZNF850 | 0.696851 | 3 | 0 | 3 |
| SRF | BHLHB9 | 0.695872 | 3 | 0 | 3 |
| SRF | DDX42 | 0.683601 | 3 | 0 | 3 |
| SRF | ARMCX3 | 0.67552 | 3 | 0 | 3 |
| SRF | ZBTB40 | 0.673557 | 5 | 0 | 5 |
| SRF | CBY1 | 0.669084 | 4 | 0 | 3 |
| SRF | CNN1 | 0.665785 | 6 | 0 | 5 |
| SRF | C7 | 0.66518 | 4 | 0 | 4 |
| SRF | FOXC1 | 0.663161 | 3 | 0 | 3 |
| SRF | B3GALNT2 | 0.660203 | 3 | 0 | 3 |
| SRF | HADH | 0.659716 | 4 | 0 | 3 |
| SRF | ADAMTSL3 | 0.652811 | 4 | 0 | 3 |
| SRF | LPP | 0.651599 | 7 | 0 | 6 |
| SRF | FAM20B | 0.651032 | 5 | 0 | 4 |
| SRF | RBMX2 | 0.647709 | 3 | 0 | 3 |
| SRF | TSPAN15 | 0.646805 | 4 | 0 | 3 |
| SRF | OAZ2 | 0.646258 | 3 | 0 | 3 |
| SRF | UST | 0.643104 | 4 | 0 | 3 |
For details and further investigation, click here
