| Full name: RAD51 paralog C | Alias Symbol: RAD51L2|FANCO | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 5889 | HGNC ID: HGNC:9820 | Ensembl Gene: ENSG00000108384 | OMIM ID: 602774 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RAD51C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of RAD51C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAD51C | 5889 | 209849_s_at | 0.1330 | 0.8520 | |
| GSE20347 | RAD51C | 5889 | 209849_s_at | 0.5985 | 0.0105 | |
| GSE23400 | RAD51C | 5889 | 209849_s_at | 0.3876 | 0.0000 | |
| GSE26886 | RAD51C | 5889 | 209849_s_at | 0.3350 | 0.1035 | |
| GSE29001 | RAD51C | 5889 | 209849_s_at | 0.5321 | 0.1767 | |
| GSE38129 | RAD51C | 5889 | 209849_s_at | 0.4857 | 0.0121 | |
| GSE45670 | RAD51C | 5889 | 209849_s_at | 0.3294 | 0.1781 | |
| GSE53622 | RAD51C | 5889 | 14830 | 0.2800 | 0.0007 | |
| GSE53624 | RAD51C | 5889 | 43047 | 0.6871 | 0.0000 | |
| GSE63941 | RAD51C | 5889 | 209849_s_at | 0.5005 | 0.3079 | |
| GSE77861 | RAD51C | 5889 | 206066_s_at | 0.3616 | 0.0578 | |
| GSE97050 | RAD51C | 5889 | A_23_P207014 | 0.0626 | 0.8312 | |
| SRP007169 | RAD51C | 5889 | RNAseq | 1.0351 | 0.0268 | |
| SRP008496 | RAD51C | 5889 | RNAseq | 1.5572 | 0.0034 | |
| SRP064894 | RAD51C | 5889 | RNAseq | 0.4156 | 0.0310 | |
| SRP133303 | RAD51C | 5889 | RNAseq | 0.6261 | 0.0002 | |
| SRP159526 | RAD51C | 5889 | RNAseq | 1.0329 | 0.0080 | |
| SRP193095 | RAD51C | 5889 | RNAseq | 0.2721 | 0.0053 | |
| SRP219564 | RAD51C | 5889 | RNAseq | 0.5391 | 0.1489 | |
| TCGA | RAD51C | 5889 | RNAseq | 0.1687 | 0.0156 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by RAD51C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAD51C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAD51C | 5889 | 6 | 1 | 23 | |
| GSE20123 | RAD51C | 5889 | 6 | 1 | 23 | |
| GSE43470 | RAD51C | 5889 | 3 | 0 | 40 | |
| GSE46452 | RAD51C | 5889 | 32 | 0 | 27 | |
| GSE47630 | RAD51C | 5889 | 7 | 1 | 32 | |
| GSE54993 | RAD51C | 5889 | 2 | 5 | 63 | |
| GSE54994 | RAD51C | 5889 | 8 | 6 | 39 | |
| GSE60625 | RAD51C | 5889 | 4 | 0 | 7 | |
| GSE74703 | RAD51C | 5889 | 3 | 0 | 33 | |
| GSE74704 | RAD51C | 5889 | 5 | 1 | 14 | |
| TCGA | RAD51C | 5889 | 26 | 7 | 63 |
Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.
Somatic mutations of RAD51C:
Generating mutation plots.
Highly correlated genes for RAD51C:
Showing top 20/187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAD51C | SF3A3 | 0.685871 | 4 | 0 | 3 |
| RAD51C | NSUN6 | 0.660898 | 3 | 0 | 3 |
| RAD51C | POC1B | 0.647424 | 3 | 0 | 3 |
| RAD51C | MPC2 | 0.634863 | 5 | 0 | 4 |
| RAD51C | ALX1 | 0.633797 | 3 | 0 | 3 |
| RAD51C | SLC5A6 | 0.63235 | 6 | 0 | 5 |
| RAD51C | CX3CL1 | 0.631322 | 4 | 0 | 4 |
| RAD51C | ASB16-AS1 | 0.630712 | 3 | 0 | 3 |
| RAD51C | BEND7 | 0.629308 | 3 | 0 | 3 |
| RAD51C | ZNF48 | 0.616059 | 4 | 0 | 3 |
| RAD51C | POLR3K | 0.60909 | 9 | 0 | 7 |
| RAD51C | MIIP | 0.605079 | 4 | 0 | 3 |
| RAD51C | ACTR3B | 0.59296 | 9 | 0 | 8 |
| RAD51C | RAD51D | 0.592817 | 6 | 0 | 5 |
| RAD51C | SNRNP25 | 0.59168 | 10 | 0 | 7 |
| RAD51C | FAHD2A | 0.59132 | 7 | 0 | 5 |
| RAD51C | SLC9B2 | 0.588439 | 3 | 0 | 3 |
| RAD51C | HIRIP3 | 0.587583 | 9 | 0 | 6 |
| RAD51C | MDC1 | 0.585917 | 9 | 0 | 7 |
| RAD51C | CHP2 | 0.585236 | 4 | 0 | 3 |
For details and further investigation, click here
