| Full name: C-X3-C motif chemokine receptor 1 | Alias Symbol: CMKDR1|V28|CCRL1 | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 1524 | HGNC ID: HGNC:2558 | Ensembl Gene: ENSG00000168329 | OMIM ID: 601470 |
| Drug and gene relationship at DGIdb | |||
CX3CR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CX3CR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CX3CR1 | 1524 | 205898_at | -0.4131 | 0.6545 | |
| GSE20347 | CX3CR1 | 1524 | 205898_at | -0.6007 | 0.0013 | |
| GSE23400 | CX3CR1 | 1524 | 205898_at | -0.2373 | 0.0000 | |
| GSE26886 | CX3CR1 | 1524 | 205898_at | -2.1975 | 0.0000 | |
| GSE29001 | CX3CR1 | 1524 | 205898_at | -0.3439 | 0.4745 | |
| GSE38129 | CX3CR1 | 1524 | 205898_at | -0.6111 | 0.0012 | |
| GSE45670 | CX3CR1 | 1524 | 205898_at | -1.0396 | 0.0742 | |
| GSE53622 | CX3CR1 | 1524 | 18262 | -1.6846 | 0.0000 | |
| GSE53624 | CX3CR1 | 1524 | 18262 | -1.5547 | 0.0000 | |
| GSE63941 | CX3CR1 | 1524 | 1568934_at | 0.1484 | 0.3459 | |
| GSE77861 | CX3CR1 | 1524 | 1568934_at | 0.0036 | 0.9717 | |
| GSE97050 | CX3CR1 | 1524 | A_23_P407565 | -0.5604 | 0.1466 | |
| SRP133303 | CX3CR1 | 1524 | RNAseq | -1.1301 | 0.0350 | |
| SRP159526 | CX3CR1 | 1524 | RNAseq | -2.4129 | 0.0057 | |
| SRP219564 | CX3CR1 | 1524 | RNAseq | -2.4942 | 0.0000 | |
| TCGA | CX3CR1 | 1524 | RNAseq | 0.0435 | 0.8848 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by CX3CR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CX3CR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CX3CR1 | 1524 | 0 | 19 | 11 | |
| GSE20123 | CX3CR1 | 1524 | 0 | 19 | 11 | |
| GSE43470 | CX3CR1 | 1524 | 0 | 20 | 23 | |
| GSE46452 | CX3CR1 | 1524 | 2 | 17 | 40 | |
| GSE47630 | CX3CR1 | 1524 | 1 | 25 | 14 | |
| GSE54993 | CX3CR1 | 1524 | 7 | 2 | 61 | |
| GSE54994 | CX3CR1 | 1524 | 1 | 33 | 19 | |
| GSE60625 | CX3CR1 | 1524 | 5 | 0 | 6 | |
| GSE74703 | CX3CR1 | 1524 | 0 | 16 | 20 | |
| GSE74704 | CX3CR1 | 1524 | 0 | 13 | 7 | |
| TCGA | CX3CR1 | 1524 | 1 | 71 | 24 |
Total number of gains: 17; Total number of losses: 235; Total Number of normals: 236.
Somatic mutations of CX3CR1:
Generating mutation plots.
Highly correlated genes for CX3CR1:
Showing top 20/890 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CX3CR1 | NR2F1 | 0.77862 | 3 | 0 | 3 |
| CX3CR1 | GIMAP5 | 0.771388 | 3 | 0 | 3 |
| CX3CR1 | CYP2U1 | 0.761148 | 4 | 0 | 4 |
| CX3CR1 | CLEC3B | 0.750367 | 3 | 0 | 3 |
| CX3CR1 | GPRASP2 | 0.743231 | 3 | 0 | 3 |
| CX3CR1 | KBTBD3 | 0.742255 | 3 | 0 | 3 |
| CX3CR1 | SF3A1 | 0.740316 | 4 | 0 | 4 |
| CX3CR1 | PPP1R3D | 0.739004 | 3 | 0 | 3 |
| CX3CR1 | CYYR1 | 0.727043 | 5 | 0 | 5 |
| CX3CR1 | TNFSF12 | 0.722901 | 3 | 0 | 3 |
| CX3CR1 | SORCS1 | 0.722027 | 3 | 0 | 3 |
| CX3CR1 | EIF4E3 | 0.721533 | 5 | 0 | 5 |
| CX3CR1 | FEM1B | 0.719305 | 3 | 0 | 3 |
| CX3CR1 | OXNAD1 | 0.716773 | 3 | 0 | 3 |
| CX3CR1 | GAB3 | 0.71642 | 4 | 0 | 4 |
| CX3CR1 | ZNF879 | 0.714738 | 5 | 0 | 5 |
| CX3CR1 | HGF | 0.714418 | 3 | 0 | 3 |
| CX3CR1 | CYP4V2 | 0.710396 | 3 | 0 | 3 |
| CX3CR1 | UTP14C | 0.70439 | 3 | 0 | 3 |
| CX3CR1 | ZNF17 | 0.698363 | 3 | 0 | 3 |
For details and further investigation, click here
