| Full name: splicing factor 3a subunit 1 | Alias Symbol: SF3a120|SAP114|PRPF21|Prp21 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 10291 | HGNC ID: HGNC:10765 | Ensembl Gene: ENSG00000099995 | OMIM ID: 605595 |
| Drug and gene relationship at DGIdb | |||
Expression of SF3A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SF3A1 | 10291 | 201356_at | -0.2197 | 0.4465 | |
| GSE20347 | SF3A1 | 10291 | 216457_s_at | 0.0107 | 0.9527 | |
| GSE23400 | SF3A1 | 10291 | 201356_at | 0.0727 | 0.0964 | |
| GSE26886 | SF3A1 | 10291 | 201356_at | -0.0127 | 0.9499 | |
| GSE29001 | SF3A1 | 10291 | 201356_at | 0.2165 | 0.3549 | |
| GSE38129 | SF3A1 | 10291 | 216457_s_at | 0.0210 | 0.8639 | |
| GSE45670 | SF3A1 | 10291 | 201356_at | -0.0279 | 0.8046 | |
| GSE53622 | SF3A1 | 10291 | 39034 | -0.6038 | 0.0000 | |
| GSE53624 | SF3A1 | 10291 | 39034 | -0.4887 | 0.0000 | |
| GSE63941 | SF3A1 | 10291 | 216457_s_at | 0.4787 | 0.0338 | |
| GSE77861 | SF3A1 | 10291 | 216457_s_at | 0.2028 | 0.4386 | |
| GSE97050 | SF3A1 | 10291 | A_33_P3210059 | -0.3970 | 0.1255 | |
| SRP007169 | SF3A1 | 10291 | RNAseq | 0.7056 | 0.1481 | |
| SRP008496 | SF3A1 | 10291 | RNAseq | 0.8084 | 0.0164 | |
| SRP064894 | SF3A1 | 10291 | RNAseq | -0.0619 | 0.6512 | |
| SRP133303 | SF3A1 | 10291 | RNAseq | -0.2009 | 0.1324 | |
| SRP159526 | SF3A1 | 10291 | RNAseq | -0.1205 | 0.4113 | |
| SRP193095 | SF3A1 | 10291 | RNAseq | 0.0414 | 0.6694 | |
| SRP219564 | SF3A1 | 10291 | RNAseq | 0.3256 | 0.4340 | |
| TCGA | SF3A1 | 10291 | RNAseq | -0.0105 | 0.7987 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SF3A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SF3A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SF3A1 | 10291 | 5 | 5 | 20 | |
| GSE20123 | SF3A1 | 10291 | 5 | 4 | 21 | |
| GSE43470 | SF3A1 | 10291 | 4 | 6 | 33 | |
| GSE46452 | SF3A1 | 10291 | 31 | 1 | 27 | |
| GSE47630 | SF3A1 | 10291 | 8 | 5 | 27 | |
| GSE54993 | SF3A1 | 10291 | 3 | 6 | 61 | |
| GSE54994 | SF3A1 | 10291 | 11 | 8 | 34 | |
| GSE60625 | SF3A1 | 10291 | 5 | 0 | 6 | |
| GSE74703 | SF3A1 | 10291 | 4 | 5 | 27 | |
| GSE74704 | SF3A1 | 10291 | 2 | 1 | 17 | |
| TCGA | SF3A1 | 10291 | 27 | 15 | 54 |
Total number of gains: 105; Total number of losses: 56; Total Number of normals: 327.
Somatic mutations of SF3A1:
Generating mutation plots.
Highly correlated genes for SF3A1:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SF3A1 | CCNDBP1 | 0.782712 | 3 | 0 | 3 |
| SF3A1 | PRKCE | 0.766094 | 3 | 0 | 3 |
| SF3A1 | NFIA | 0.758968 | 3 | 0 | 3 |
| SF3A1 | KLHDC3 | 0.758623 | 3 | 0 | 3 |
| SF3A1 | BEGAIN | 0.752663 | 3 | 0 | 3 |
| SF3A1 | TMEM219 | 0.740935 | 3 | 0 | 3 |
| SF3A1 | CX3CR1 | 0.740316 | 4 | 0 | 4 |
| SF3A1 | BOD1 | 0.73852 | 3 | 0 | 3 |
| SF3A1 | BEX5 | 0.738368 | 3 | 0 | 3 |
| SF3A1 | CLEC3B | 0.738359 | 3 | 0 | 3 |
| SF3A1 | FBXO10 | 0.735628 | 3 | 0 | 3 |
| SF3A1 | MMRN1 | 0.729846 | 4 | 0 | 4 |
| SF3A1 | EPC1 | 0.728155 | 3 | 0 | 3 |
| SF3A1 | CCDC7 | 0.725516 | 3 | 0 | 3 |
| SF3A1 | C11orf68 | 0.714394 | 3 | 0 | 3 |
| SF3A1 | CHURC1 | 0.713077 | 3 | 0 | 3 |
| SF3A1 | NR2F1 | 0.709521 | 3 | 0 | 3 |
| SF3A1 | FAM199X | 0.708298 | 3 | 0 | 3 |
| SF3A1 | IGIP | 0.707759 | 3 | 0 | 3 |
| SF3A1 | CNOT6L | 0.70427 | 4 | 0 | 3 |
For details and further investigation, click here
