| Full name: protein phosphatase 1 regulatory subunit 3D | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 5509 | HGNC ID: HGNC:9294 | Ensembl Gene: ENSG00000132825 | OMIM ID: 603326 |
| Drug and gene relationship at DGIdb | |||
PPP1R3D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance |
Expression of PPP1R3D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R3D | 5509 | 204554_at | 0.5918 | 0.2280 | |
| GSE20347 | PPP1R3D | 5509 | 204554_at | -0.4879 | 0.0262 | |
| GSE23400 | PPP1R3D | 5509 | 204554_at | -0.0827 | 0.3394 | |
| GSE26886 | PPP1R3D | 5509 | 204554_at | -1.0085 | 0.0010 | |
| GSE29001 | PPP1R3D | 5509 | 204555_s_at | -0.1327 | 0.6154 | |
| GSE38129 | PPP1R3D | 5509 | 204554_at | -0.2038 | 0.3246 | |
| GSE45670 | PPP1R3D | 5509 | 204554_at | 0.2216 | 0.2575 | |
| GSE53622 | PPP1R3D | 5509 | 68368 | -0.2348 | 0.0257 | |
| GSE53624 | PPP1R3D | 5509 | 68368 | -0.1921 | 0.0104 | |
| GSE63941 | PPP1R3D | 5509 | 204554_at | 0.3239 | 0.4496 | |
| GSE77861 | PPP1R3D | 5509 | 204554_at | -0.3129 | 0.2464 | |
| GSE97050 | PPP1R3D | 5509 | A_33_P3423859 | 0.1555 | 0.7069 | |
| SRP007169 | PPP1R3D | 5509 | RNAseq | -0.9139 | 0.0416 | |
| SRP008496 | PPP1R3D | 5509 | RNAseq | -0.7486 | 0.0379 | |
| SRP064894 | PPP1R3D | 5509 | RNAseq | -0.1682 | 0.4562 | |
| SRP133303 | PPP1R3D | 5509 | RNAseq | 0.0163 | 0.9378 | |
| SRP159526 | PPP1R3D | 5509 | RNAseq | -0.1257 | 0.7430 | |
| SRP193095 | PPP1R3D | 5509 | RNAseq | -0.4487 | 0.0048 | |
| SRP219564 | PPP1R3D | 5509 | RNAseq | 0.0878 | 0.8310 | |
| TCGA | PPP1R3D | 5509 | RNAseq | 0.1679 | 0.0066 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PPP1R3D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R3D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R3D | 5509 | 13 | 2 | 15 | |
| GSE20123 | PPP1R3D | 5509 | 13 | 2 | 15 | |
| GSE43470 | PPP1R3D | 5509 | 13 | 0 | 30 | |
| GSE46452 | PPP1R3D | 5509 | 29 | 0 | 30 | |
| GSE47630 | PPP1R3D | 5509 | 24 | 1 | 15 | |
| GSE54993 | PPP1R3D | 5509 | 0 | 17 | 53 | |
| GSE54994 | PPP1R3D | 5509 | 29 | 0 | 24 | |
| GSE60625 | PPP1R3D | 5509 | 0 | 0 | 11 | |
| GSE74703 | PPP1R3D | 5509 | 11 | 0 | 25 | |
| GSE74704 | PPP1R3D | 5509 | 10 | 0 | 10 | |
| TCGA | PPP1R3D | 5509 | 43 | 4 | 49 |
Total number of gains: 185; Total number of losses: 26; Total Number of normals: 277.
Somatic mutations of PPP1R3D:
Generating mutation plots.
Highly correlated genes for PPP1R3D:
Showing top 20/423 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R3D | RASA2 | 0.837796 | 3 | 0 | 3 |
| PPP1R3D | TMEM167A | 0.798029 | 3 | 0 | 3 |
| PPP1R3D | GLE1 | 0.79583 | 3 | 0 | 3 |
| PPP1R3D | EAF1 | 0.769823 | 3 | 0 | 3 |
| PPP1R3D | PCNT | 0.76272 | 3 | 0 | 3 |
| PPP1R3D | ELMOD2 | 0.761729 | 3 | 0 | 3 |
| PPP1R3D | C6orf62 | 0.761068 | 3 | 0 | 3 |
| PPP1R3D | RALGAPA2 | 0.760273 | 3 | 0 | 3 |
| PPP1R3D | SNX30 | 0.757891 | 3 | 0 | 3 |
| PPP1R3D | SLC30A4 | 0.757131 | 3 | 0 | 3 |
| PPP1R3D | ANKRD13C | 0.754036 | 3 | 0 | 3 |
| PPP1R3D | RSPRY1 | 0.745619 | 3 | 0 | 3 |
| PPP1R3D | VCPIP1 | 0.745465 | 3 | 0 | 3 |
| PPP1R3D | SLC30A6 | 0.74546 | 3 | 0 | 3 |
| PPP1R3D | GORASP2 | 0.743419 | 3 | 0 | 3 |
| PPP1R3D | CX3CR1 | 0.739004 | 3 | 0 | 3 |
| PPP1R3D | HDAC11 | 0.732238 | 3 | 0 | 3 |
| PPP1R3D | CBL | 0.731348 | 3 | 0 | 3 |
| PPP1R3D | OSTC | 0.727409 | 3 | 0 | 3 |
| PPP1R3D | TTLL4 | 0.725935 | 3 | 0 | 3 |
For details and further investigation, click here
