| Full name: CXXC finger protein 4 | Alias Symbol: IDAX | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 80319 | HGNC ID: HGNC:24593 | Ensembl Gene: ENSG00000168772 | OMIM ID: 611645 |
| Drug and gene relationship at DGIdb | |||
CXXC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of CXXC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXXC4 | 80319 | 220277_at | -0.0612 | 0.9078 | |
| GSE20347 | CXXC4 | 80319 | 220277_at | 0.0150 | 0.9040 | |
| GSE23400 | CXXC4 | 80319 | 220277_at | -0.1287 | 0.0008 | |
| GSE26886 | CXXC4 | 80319 | 220277_at | 0.4391 | 0.0077 | |
| GSE29001 | CXXC4 | 80319 | 220277_at | -0.1726 | 0.1795 | |
| GSE38129 | CXXC4 | 80319 | 220277_at | -0.0595 | 0.6928 | |
| GSE45670 | CXXC4 | 80319 | 220277_at | -0.3392 | 0.0001 | |
| GSE53622 | CXXC4 | 80319 | 135413 | -0.5465 | 0.0556 | |
| GSE53624 | CXXC4 | 80319 | 135413 | 0.1437 | 0.5037 | |
| GSE63941 | CXXC4 | 80319 | 220277_at | 0.3295 | 0.3479 | |
| GSE77861 | CXXC4 | 80319 | 220277_at | -0.1127 | 0.2965 | |
| SRP133303 | CXXC4 | 80319 | RNAseq | 0.2087 | 0.6065 | |
| SRP159526 | CXXC4 | 80319 | RNAseq | 2.3954 | 0.0063 | |
| TCGA | CXXC4 | 80319 | RNAseq | -0.2289 | 0.7120 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CXXC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXXC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXXC4 | 80319 | 0 | 12 | 18 | |
| GSE20123 | CXXC4 | 80319 | 0 | 12 | 18 | |
| GSE43470 | CXXC4 | 80319 | 0 | 13 | 30 | |
| GSE46452 | CXXC4 | 80319 | 1 | 36 | 22 | |
| GSE47630 | CXXC4 | 80319 | 0 | 20 | 20 | |
| GSE54993 | CXXC4 | 80319 | 9 | 0 | 61 | |
| GSE54994 | CXXC4 | 80319 | 1 | 10 | 42 | |
| GSE60625 | CXXC4 | 80319 | 0 | 3 | 8 | |
| GSE74703 | CXXC4 | 80319 | 0 | 11 | 25 | |
| GSE74704 | CXXC4 | 80319 | 0 | 6 | 14 | |
| TCGA | CXXC4 | 80319 | 7 | 38 | 51 |
Total number of gains: 18; Total number of losses: 161; Total Number of normals: 309.
Somatic mutations of CXXC4:
Generating mutation plots.
Highly correlated genes for CXXC4:
Showing top 20/156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXXC4 | B4GALT6 | 0.695989 | 4 | 0 | 4 |
| CXXC4 | MAATS1 | 0.647708 | 4 | 0 | 4 |
| CXXC4 | RBPMS2 | 0.628947 | 3 | 0 | 3 |
| CXXC4 | MTFR1L | 0.618716 | 3 | 0 | 3 |
| CXXC4 | CLDN3 | 0.616863 | 5 | 0 | 3 |
| CXXC4 | USP27X-AS1 | 0.61133 | 3 | 0 | 3 |
| CXXC4 | TMEM170B | 0.604753 | 4 | 0 | 3 |
| CXXC4 | RASSF2 | 0.598791 | 5 | 0 | 3 |
| CXXC4 | PLCL1 | 0.594638 | 6 | 0 | 5 |
| CXXC4 | YPEL1 | 0.593889 | 7 | 0 | 5 |
| CXXC4 | TTLL1 | 0.590318 | 4 | 0 | 3 |
| CXXC4 | MYBPC1 | 0.589677 | 4 | 0 | 3 |
| CXXC4 | ZBTB10 | 0.588581 | 3 | 0 | 3 |
| CXXC4 | TRAM2-AS1 | 0.587091 | 4 | 0 | 3 |
| CXXC4 | PENK | 0.586743 | 4 | 0 | 4 |
| CXXC4 | HIGD2A | 0.586548 | 5 | 0 | 3 |
| CXXC4 | MB | 0.586037 | 6 | 0 | 4 |
| CXXC4 | PLEKHB1 | 0.585156 | 7 | 0 | 6 |
| CXXC4 | RNFT2 | 0.579805 | 5 | 0 | 3 |
| CXXC4 | WDR35 | 0.578232 | 5 | 0 | 3 |
For details and further investigation, click here
