| Full name: tubulin tyrosine ligase like 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 25809 | HGNC ID: HGNC:1312 | Ensembl Gene: ENSG00000100271 | OMIM ID: 608955 |
| Drug and gene relationship at DGIdb | |||
Expression of TTLL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTLL1 | 25809 | 205652_s_at | 0.0657 | 0.9264 | |
| GSE20347 | TTLL1 | 25809 | 205652_s_at | -0.0809 | 0.6619 | |
| GSE23400 | TTLL1 | 25809 | 205652_s_at | -0.0832 | 0.0546 | |
| GSE26886 | TTLL1 | 25809 | 205652_s_at | 0.5971 | 0.0321 | |
| GSE29001 | TTLL1 | 25809 | 205652_s_at | 0.1014 | 0.7565 | |
| GSE38129 | TTLL1 | 25809 | 205652_s_at | -0.0551 | 0.7183 | |
| GSE45670 | TTLL1 | 25809 | 205652_s_at | -0.1292 | 0.5600 | |
| GSE53622 | TTLL1 | 25809 | 43545 | -0.0588 | 0.5640 | |
| GSE53624 | TTLL1 | 25809 | 43545 | 0.0821 | 0.4109 | |
| GSE63941 | TTLL1 | 25809 | 205652_s_at | -1.0046 | 0.1129 | |
| GSE77861 | TTLL1 | 25809 | 205652_s_at | 0.0033 | 0.9883 | |
| GSE97050 | TTLL1 | 25809 | A_33_P3385957 | -0.4368 | 0.2152 | |
| SRP064894 | TTLL1 | 25809 | RNAseq | 0.8280 | 0.0025 | |
| SRP133303 | TTLL1 | 25809 | RNAseq | -0.0931 | 0.6467 | |
| SRP159526 | TTLL1 | 25809 | RNAseq | 0.4616 | 0.1026 | |
| SRP193095 | TTLL1 | 25809 | RNAseq | -0.0037 | 0.9825 | |
| SRP219564 | TTLL1 | 25809 | RNAseq | 1.2553 | 0.0355 | |
| TCGA | TTLL1 | 25809 | RNAseq | -0.1078 | 0.3457 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TTLL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTLL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTLL1 | 25809 | 6 | 6 | 18 | |
| GSE20123 | TTLL1 | 25809 | 6 | 5 | 19 | |
| GSE43470 | TTLL1 | 25809 | 3 | 6 | 34 | |
| GSE46452 | TTLL1 | 25809 | 31 | 2 | 26 | |
| GSE47630 | TTLL1 | 25809 | 9 | 4 | 27 | |
| GSE54993 | TTLL1 | 25809 | 3 | 6 | 61 | |
| GSE54994 | TTLL1 | 25809 | 11 | 8 | 34 | |
| GSE60625 | TTLL1 | 25809 | 5 | 0 | 6 | |
| GSE74703 | TTLL1 | 25809 | 3 | 4 | 29 | |
| GSE74704 | TTLL1 | 25809 | 3 | 3 | 14 | |
| TCGA | TTLL1 | 25809 | 26 | 15 | 55 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of TTLL1:
Generating mutation plots.
Highly correlated genes for TTLL1:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTLL1 | MEPCE | 0.795545 | 4 | 0 | 4 |
| TTLL1 | CHCHD6 | 0.766082 | 3 | 0 | 3 |
| TTLL1 | FAM89B | 0.757819 | 3 | 0 | 3 |
| TTLL1 | ABHD14B | 0.757316 | 3 | 0 | 3 |
| TTLL1 | ARL6IP4 | 0.752443 | 3 | 0 | 3 |
| TTLL1 | NXF1 | 0.749895 | 3 | 0 | 3 |
| TTLL1 | PAN2 | 0.743587 | 3 | 0 | 3 |
| TTLL1 | PANK4 | 0.742849 | 3 | 0 | 3 |
| TTLL1 | PCID2 | 0.74239 | 3 | 0 | 3 |
| TTLL1 | BTG1 | 0.740547 | 3 | 0 | 3 |
| TTLL1 | ZZEF1 | 0.740402 | 3 | 0 | 3 |
| TTLL1 | PTPN9 | 0.737548 | 3 | 0 | 3 |
| TTLL1 | UQCRFS1 | 0.735018 | 3 | 0 | 3 |
| TTLL1 | METAP1D | 0.734778 | 3 | 0 | 3 |
| TTLL1 | ZNF319 | 0.733928 | 3 | 0 | 3 |
| TTLL1 | HCFC1 | 0.729393 | 3 | 0 | 3 |
| TTLL1 | ZKSCAN1 | 0.725026 | 3 | 0 | 3 |
| TTLL1 | TBC1D5 | 0.723901 | 3 | 0 | 3 |
| TTLL1 | MXD3 | 0.72369 | 3 | 0 | 3 |
| TTLL1 | PPP2R2D | 0.714932 | 3 | 0 | 3 |
For details and further investigation, click here
