| Full name: HIG1 hypoxia inducible domain family member 2A | Alias Symbol: MGC2198|RCF1B | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 192286 | HGNC ID: HGNC:28311 | Ensembl Gene: ENSG00000146066 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HIGD2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIGD2A | 192286 | 209329_x_at | -0.0337 | 0.9569 | |
| GSE20347 | HIGD2A | 192286 | 209329_x_at | -0.2539 | 0.1343 | |
| GSE23400 | HIGD2A | 192286 | 209329_x_at | -0.0444 | 0.5324 | |
| GSE26886 | HIGD2A | 192286 | 209329_x_at | 0.3977 | 0.0623 | |
| GSE29001 | HIGD2A | 192286 | 209329_x_at | -0.2032 | 0.4715 | |
| GSE38129 | HIGD2A | 192286 | 209329_x_at | -0.3012 | 0.0354 | |
| GSE45670 | HIGD2A | 192286 | 209329_x_at | -0.2834 | 0.0345 | |
| GSE53622 | HIGD2A | 192286 | 93823 | -0.1113 | 0.1608 | |
| GSE53624 | HIGD2A | 192286 | 93823 | 0.0183 | 0.8360 | |
| GSE63941 | HIGD2A | 192286 | 209329_x_at | 1.2013 | 0.0019 | |
| GSE77861 | HIGD2A | 192286 | 209329_x_at | -0.0706 | 0.7723 | |
| GSE97050 | HIGD2A | 192286 | A_23_P304386 | 0.0545 | 0.8914 | |
| SRP007169 | HIGD2A | 192286 | RNAseq | -0.6458 | 0.0321 | |
| SRP008496 | HIGD2A | 192286 | RNAseq | -0.9284 | 0.0001 | |
| SRP064894 | HIGD2A | 192286 | RNAseq | 0.2450 | 0.4683 | |
| SRP133303 | HIGD2A | 192286 | RNAseq | -0.2575 | 0.0399 | |
| SRP159526 | HIGD2A | 192286 | RNAseq | -0.1974 | 0.5891 | |
| SRP193095 | HIGD2A | 192286 | RNAseq | -0.5504 | 0.0000 | |
| SRP219564 | HIGD2A | 192286 | RNAseq | 0.0510 | 0.9198 | |
| TCGA | HIGD2A | 192286 | RNAseq | -0.0625 | 0.2675 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HIGD2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIGD2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIGD2A | 192286 | 2 | 13 | 15 | |
| GSE20123 | HIGD2A | 192286 | 2 | 13 | 15 | |
| GSE43470 | HIGD2A | 192286 | 1 | 11 | 31 | |
| GSE46452 | HIGD2A | 192286 | 0 | 27 | 32 | |
| GSE47630 | HIGD2A | 192286 | 0 | 20 | 20 | |
| GSE54993 | HIGD2A | 192286 | 10 | 2 | 58 | |
| GSE54994 | HIGD2A | 192286 | 2 | 17 | 34 | |
| GSE60625 | HIGD2A | 192286 | 1 | 0 | 10 | |
| GSE74703 | HIGD2A | 192286 | 1 | 7 | 28 | |
| GSE74704 | HIGD2A | 192286 | 1 | 6 | 13 | |
| TCGA | HIGD2A | 192286 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of HIGD2A:
Generating mutation plots.
Highly correlated genes for HIGD2A:
Showing top 20/495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIGD2A | CPNE1 | 0.769665 | 3 | 0 | 3 |
| HIGD2A | BBX | 0.768182 | 3 | 0 | 3 |
| HIGD2A | TAB1 | 0.716714 | 4 | 0 | 3 |
| HIGD2A | KCND3 | 0.716052 | 3 | 0 | 3 |
| HIGD2A | ZXDB | 0.715621 | 4 | 0 | 4 |
| HIGD2A | ANP32B | 0.71423 | 3 | 0 | 3 |
| HIGD2A | DMAP1 | 0.712884 | 4 | 0 | 3 |
| HIGD2A | ORAI1 | 0.71263 | 3 | 0 | 3 |
| HIGD2A | TSNARE1 | 0.707297 | 4 | 0 | 3 |
| HIGD2A | ZXDA | 0.707225 | 3 | 0 | 3 |
| HIGD2A | RBP2 | 0.705369 | 3 | 0 | 3 |
| HIGD2A | C6orf136 | 0.70462 | 3 | 0 | 3 |
| HIGD2A | PTPN6 | 0.701326 | 4 | 0 | 3 |
| HIGD2A | DNAJB12 | 0.697926 | 3 | 0 | 3 |
| HIGD2A | INPP5K | 0.695505 | 3 | 0 | 3 |
| HIGD2A | USP19 | 0.69387 | 4 | 0 | 4 |
| HIGD2A | METTL23 | 0.693016 | 3 | 0 | 3 |
| HIGD2A | EIF4A3 | 0.692124 | 3 | 0 | 3 |
| HIGD2A | ATG4C | 0.691014 | 3 | 0 | 3 |
| HIGD2A | TTLL1 | 0.67407 | 5 | 0 | 3 |
For details and further investigation, click here
