| Full name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Alias Symbol: SDR11E1 | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 3283 | HGNC ID: HGNC:5217 | Ensembl Gene: ENSG00000203857 | OMIM ID: 109715 |
| Drug and gene relationship at DGIdb | |||
HSD3B1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis |
Expression of HSD3B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD3B1 | 3283 | 241111_at | 0.2022 | 0.3831 | |
| GSE20347 | HSD3B1 | 3283 | 204515_at | 0.0701 | 0.3412 | |
| GSE23400 | HSD3B1 | 3283 | 204515_at | -0.0075 | 0.7979 | |
| GSE26886 | HSD3B1 | 3283 | 241111_at | -0.0232 | 0.8412 | |
| GSE29001 | HSD3B1 | 3283 | 204515_at | -0.1525 | 0.2460 | |
| GSE38129 | HSD3B1 | 3283 | 204515_at | -0.0399 | 0.6040 | |
| GSE45670 | HSD3B1 | 3283 | 241111_at | 0.1557 | 0.0848 | |
| GSE63941 | HSD3B1 | 3283 | 204515_at | 0.2525 | 0.0546 | |
| GSE77861 | HSD3B1 | 3283 | 204515_at | 0.0321 | 0.6712 | |
| GSE97050 | HSD3B1 | 3283 | A_24_P350397 | -0.2188 | 0.4608 | |
| TCGA | HSD3B1 | 3283 | RNAseq | 0.2850 | 0.9030 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSD3B1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HSD3B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD3B1 | 3283 | 3 | 5 | 22 | |
| GSE20123 | HSD3B1 | 3283 | 4 | 5 | 21 | |
| GSE43470 | HSD3B1 | 3283 | 1 | 3 | 39 | |
| GSE46452 | HSD3B1 | 3283 | 2 | 1 | 56 | |
| GSE47630 | HSD3B1 | 3283 | 10 | 4 | 26 | |
| GSE54993 | HSD3B1 | 3283 | 0 | 2 | 68 | |
| GSE54994 | HSD3B1 | 3283 | 12 | 1 | 40 | |
| GSE60625 | HSD3B1 | 3283 | 0 | 0 | 11 | |
| GSE74703 | HSD3B1 | 3283 | 1 | 3 | 32 | |
| GSE74704 | HSD3B1 | 3283 | 2 | 3 | 15 | |
| TCGA | HSD3B1 | 3283 | 18 | 23 | 55 |
Total number of gains: 53; Total number of losses: 50; Total Number of normals: 385.
Somatic mutations of HSD3B1:
Generating mutation plots.
Highly correlated genes for HSD3B1:
Showing top 20/622 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD3B1 | ACTL6B | 0.749557 | 3 | 0 | 3 |
| HSD3B1 | CPLX2 | 0.749132 | 3 | 0 | 3 |
| HSD3B1 | GRID2 | 0.73714 | 3 | 0 | 3 |
| HSD3B1 | MYH14 | 0.734975 | 3 | 0 | 3 |
| HSD3B1 | KRTAP3-1 | 0.729135 | 3 | 0 | 3 |
| HSD3B1 | SLC6A13 | 0.727862 | 5 | 0 | 5 |
| HSD3B1 | GRIN1 | 0.726476 | 4 | 0 | 4 |
| HSD3B1 | CDH4 | 0.724889 | 4 | 0 | 3 |
| HSD3B1 | FXYD2 | 0.718595 | 3 | 0 | 3 |
| HSD3B1 | PGC | 0.715214 | 4 | 0 | 3 |
| HSD3B1 | SHARPIN | 0.712593 | 3 | 0 | 3 |
| HSD3B1 | CYP17A1 | 0.707046 | 4 | 0 | 4 |
| HSD3B1 | CAMK1G | 0.70063 | 3 | 0 | 3 |
| HSD3B1 | CABP4 | 0.700541 | 3 | 0 | 3 |
| HSD3B1 | NPAS1 | 0.698369 | 3 | 0 | 3 |
| HSD3B1 | CPNE6 | 0.697541 | 4 | 0 | 4 |
| HSD3B1 | TNR | 0.691844 | 5 | 0 | 5 |
| HSD3B1 | PRODH2 | 0.691664 | 5 | 0 | 5 |
| HSD3B1 | MAMSTR | 0.691183 | 4 | 0 | 3 |
| HSD3B1 | TNN | 0.690647 | 4 | 0 | 4 |
For details and further investigation, click here
