| Full name: cholinergic receptor nicotinic beta 4 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 1143 | HGNC ID: HGNC:1964 | Ensembl Gene: ENSG00000117971 | OMIM ID: 118509 |
| Drug and gene relationship at DGIdb | |||
CHRNB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse |
Expression of CHRNB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNB4 | 1143 | 207516_at | 0.1995 | 0.4419 | |
| GSE20347 | CHRNB4 | 1143 | 207516_at | 0.0413 | 0.4674 | |
| GSE23400 | CHRNB4 | 1143 | 207516_at | -0.0391 | 0.1548 | |
| GSE26886 | CHRNB4 | 1143 | 207516_at | 0.1698 | 0.0207 | |
| GSE29001 | CHRNB4 | 1143 | 207516_at | -0.0822 | 0.4517 | |
| GSE38129 | CHRNB4 | 1143 | 207516_at | -0.0036 | 0.9487 | |
| GSE45670 | CHRNB4 | 1143 | 207516_at | 0.1325 | 0.1130 | |
| GSE53622 | CHRNB4 | 1143 | 4971 | 0.0446 | 0.8319 | |
| GSE53624 | CHRNB4 | 1143 | 4971 | 0.3438 | 0.0008 | |
| GSE63941 | CHRNB4 | 1143 | 207516_at | -0.0017 | 0.9911 | |
| GSE77861 | CHRNB4 | 1143 | 207516_at | -0.1319 | 0.2455 | |
| GSE97050 | CHRNB4 | 1143 | A_23_P332789 | -0.1872 | 0.6430 | |
| SRP133303 | CHRNB4 | 1143 | RNAseq | 0.0720 | 0.7366 | |
| SRP159526 | CHRNB4 | 1143 | RNAseq | 0.7212 | 0.1356 | |
| SRP193095 | CHRNB4 | 1143 | RNAseq | 0.5107 | 0.0025 | |
| TCGA | CHRNB4 | 1143 | RNAseq | 1.1360 | 0.0012 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHRNB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNB4 | 1143 | 7 | 1 | 22 | |
| GSE20123 | CHRNB4 | 1143 | 7 | 1 | 22 | |
| GSE43470 | CHRNB4 | 1143 | 4 | 5 | 34 | |
| GSE46452 | CHRNB4 | 1143 | 3 | 7 | 49 | |
| GSE47630 | CHRNB4 | 1143 | 8 | 10 | 22 | |
| GSE54993 | CHRNB4 | 1143 | 5 | 6 | 59 | |
| GSE54994 | CHRNB4 | 1143 | 5 | 6 | 42 | |
| GSE60625 | CHRNB4 | 1143 | 4 | 0 | 7 | |
| GSE74703 | CHRNB4 | 1143 | 4 | 3 | 29 | |
| GSE74704 | CHRNB4 | 1143 | 3 | 1 | 16 | |
| TCGA | CHRNB4 | 1143 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of CHRNB4:
Generating mutation plots.
Highly correlated genes for CHRNB4:
Showing top 20/214 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNB4 | CYP17A1 | 0.761126 | 3 | 0 | 3 |
| CHRNB4 | MAGEE1 | 0.740613 | 3 | 0 | 3 |
| CHRNB4 | ADAM21 | 0.728146 | 3 | 0 | 3 |
| CHRNB4 | KLHL35 | 0.712054 | 3 | 0 | 3 |
| CHRNB4 | GNG13 | 0.70705 | 3 | 0 | 3 |
| CHRNB4 | CAPN10 | 0.698051 | 3 | 0 | 3 |
| CHRNB4 | MAGEA8 | 0.694737 | 3 | 0 | 3 |
| CHRNB4 | LRRC31 | 0.691675 | 3 | 0 | 3 |
| CHRNB4 | TEX13A | 0.690844 | 4 | 0 | 3 |
| CHRNB4 | DBF4B | 0.689771 | 3 | 0 | 3 |
| CHRNB4 | POLE4 | 0.689614 | 3 | 0 | 3 |
| CHRNB4 | PHOSPHO1 | 0.685636 | 3 | 0 | 3 |
| CHRNB4 | CADPS | 0.683151 | 3 | 0 | 3 |
| CHRNB4 | C1QTNF6 | 0.67762 | 3 | 0 | 3 |
| CHRNB4 | AQP8 | 0.676766 | 3 | 0 | 3 |
| CHRNB4 | USP51 | 0.675773 | 3 | 0 | 3 |
| CHRNB4 | MEPE | 0.673951 | 3 | 0 | 3 |
| CHRNB4 | GRID2 | 0.671209 | 3 | 0 | 3 |
| CHRNB4 | CYP2D6 | 0.665009 | 4 | 0 | 3 |
| CHRNB4 | BCL2L10 | 0.662703 | 4 | 0 | 3 |
For details and further investigation, click here
