| Full name: adrenoceptor alpha 2B | Alias Symbol: ADRARL1 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 151 | HGNC ID: HGNC:282 | Ensembl Gene: ENSG00000274286 | OMIM ID: 104260 |
| Drug and gene relationship at DGIdb | |||
ADRA2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of ADRA2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRA2B | 151 | 208544_at | -0.0718 | 0.8325 | |
| GSE20347 | ADRA2B | 151 | 208544_at | -0.0741 | 0.3476 | |
| GSE23400 | ADRA2B | 151 | 208544_at | -0.1559 | 0.0006 | |
| GSE26886 | ADRA2B | 151 | 208544_at | -0.0432 | 0.8053 | |
| GSE29001 | ADRA2B | 151 | 208544_at | -0.0980 | 0.6416 | |
| GSE38129 | ADRA2B | 151 | 208544_at | -0.1292 | 0.0824 | |
| GSE45670 | ADRA2B | 151 | 208544_at | 0.0901 | 0.3713 | |
| GSE53622 | ADRA2B | 151 | 36953 | -0.0918 | 0.2738 | |
| GSE53624 | ADRA2B | 151 | 36953 | 0.0597 | 0.6020 | |
| GSE63941 | ADRA2B | 151 | 208544_at | 0.2577 | 0.1008 | |
| GSE77861 | ADRA2B | 151 | 208544_at | -0.0050 | 0.9814 | |
| SRP133303 | ADRA2B | 151 | RNAseq | -1.0056 | 0.0175 | |
| SRP159526 | ADRA2B | 151 | RNAseq | 1.9148 | 0.0015 | |
| SRP219564 | ADRA2B | 151 | RNAseq | -0.4672 | 0.5550 | |
| TCGA | ADRA2B | 151 | RNAseq | -0.1103 | 0.7471 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ADRA2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADRA2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRA2B | 151 | 6 | 2 | 22 | |
| GSE20123 | ADRA2B | 151 | 6 | 2 | 22 | |
| GSE43470 | ADRA2B | 151 | 2 | 3 | 38 | |
| GSE46452 | ADRA2B | 151 | 2 | 3 | 54 | |
| GSE47630 | ADRA2B | 151 | 7 | 0 | 33 | |
| GSE54993 | ADRA2B | 151 | 0 | 6 | 64 | |
| GSE54994 | ADRA2B | 151 | 11 | 0 | 42 | |
| GSE60625 | ADRA2B | 151 | 0 | 3 | 8 | |
| GSE74703 | ADRA2B | 151 | 2 | 2 | 32 | |
| GSE74704 | ADRA2B | 151 | 4 | 1 | 15 | |
| TCGA | ADRA2B | 151 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of ADRA2B:
Generating mutation plots.
Highly correlated genes for ADRA2B:
Showing top 20/647 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRA2B | LIPF | 0.739379 | 3 | 0 | 3 |
| ADRA2B | SPTB | 0.728948 | 3 | 0 | 3 |
| ADRA2B | CYP17A1 | 0.707542 | 5 | 0 | 5 |
| ADRA2B | GNRH2 | 0.694445 | 5 | 0 | 5 |
| ADRA2B | CITED1 | 0.691343 | 3 | 0 | 3 |
| ADRA2B | SYT5 | 0.684994 | 3 | 0 | 3 |
| ADRA2B | RHAG | 0.675524 | 4 | 0 | 3 |
| ADRA2B | TNFRSF13B | 0.671955 | 4 | 0 | 3 |
| ADRA2B | ACADS | 0.66923 | 3 | 0 | 3 |
| ADRA2B | CHRD | 0.662958 | 4 | 0 | 3 |
| ADRA2B | ASIC4 | 0.660135 | 5 | 0 | 5 |
| ADRA2B | NR5A1 | 0.659865 | 4 | 0 | 4 |
| ADRA2B | MYOG | 0.657787 | 5 | 0 | 3 |
| ADRA2B | GDF2 | 0.655883 | 5 | 0 | 4 |
| ADRA2B | CD4 | 0.654622 | 3 | 0 | 3 |
| ADRA2B | CELA3B | 0.651506 | 4 | 0 | 4 |
| ADRA2B | HDAC11 | 0.649085 | 5 | 0 | 4 |
| ADRA2B | KCNJ4 | 0.649024 | 3 | 0 | 3 |
| ADRA2B | RBP4 | 0.648848 | 3 | 0 | 3 |
| ADRA2B | CYP11B2 | 0.648218 | 4 | 0 | 3 |
For details and further investigation, click here
