| Full name: protein kinase cAMP-dependent type II regulatory subunit alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 5576 | HGNC ID: HGNC:9391 | Ensembl Gene: ENSG00000114302 | OMIM ID: 176910 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PRKAR2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway |
Expression of PRKAR2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKAR2A | 5576 | 225011_at | -0.2875 | 0.5948 | |
| GSE20347 | PRKAR2A | 5576 | 204842_x_at | -0.0050 | 0.9833 | |
| GSE23400 | PRKAR2A | 5576 | 213052_at | -0.3318 | 0.0000 | |
| GSE26886 | PRKAR2A | 5576 | 225011_at | -0.8311 | 0.0027 | |
| GSE29001 | PRKAR2A | 5576 | 204842_x_at | -0.1483 | 0.3442 | |
| GSE38129 | PRKAR2A | 5576 | 204842_x_at | -0.1813 | 0.3870 | |
| GSE45670 | PRKAR2A | 5576 | 225011_at | -0.3926 | 0.0150 | |
| GSE53622 | PRKAR2A | 5576 | 646 | -0.7170 | 0.0000 | |
| GSE53624 | PRKAR2A | 5576 | 646 | -0.6956 | 0.0000 | |
| GSE63941 | PRKAR2A | 5576 | 204842_x_at | 0.0914 | 0.6701 | |
| GSE77861 | PRKAR2A | 5576 | 225000_at | -1.1162 | 0.0004 | |
| GSE97050 | PRKAR2A | 5576 | A_23_P22214 | 0.0721 | 0.7691 | |
| SRP007169 | PRKAR2A | 5576 | RNAseq | -1.1653 | 0.0001 | |
| SRP008496 | PRKAR2A | 5576 | RNAseq | -1.1834 | 0.0000 | |
| SRP064894 | PRKAR2A | 5576 | RNAseq | -0.4969 | 0.0015 | |
| SRP133303 | PRKAR2A | 5576 | RNAseq | -0.5883 | 0.0006 | |
| SRP159526 | PRKAR2A | 5576 | RNAseq | -0.7580 | 0.0116 | |
| SRP193095 | PRKAR2A | 5576 | RNAseq | -0.8396 | 0.0000 | |
| SRP219564 | PRKAR2A | 5576 | RNAseq | -0.7459 | 0.0025 | |
| TCGA | PRKAR2A | 5576 | RNAseq | -0.3122 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PRKAR2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRKAR2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKAR2A | 5576 | 0 | 18 | 12 | |
| GSE20123 | PRKAR2A | 5576 | 0 | 19 | 11 | |
| GSE43470 | PRKAR2A | 5576 | 0 | 19 | 24 | |
| GSE46452 | PRKAR2A | 5576 | 3 | 16 | 40 | |
| GSE47630 | PRKAR2A | 5576 | 1 | 24 | 15 | |
| GSE54993 | PRKAR2A | 5576 | 6 | 2 | 62 | |
| GSE54994 | PRKAR2A | 5576 | 0 | 37 | 16 | |
| GSE60625 | PRKAR2A | 5576 | 5 | 0 | 6 | |
| GSE74703 | PRKAR2A | 5576 | 0 | 15 | 21 | |
| GSE74704 | PRKAR2A | 5576 | 0 | 12 | 8 | |
| TCGA | PRKAR2A | 5576 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 240; Total Number of normals: 233.
Somatic mutations of PRKAR2A:
Generating mutation plots.
Highly correlated genes for PRKAR2A:
Showing top 20/1488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKAR2A | SCP2 | 0.806846 | 6 | 0 | 6 |
| PRKAR2A | TRIP11 | 0.784436 | 3 | 0 | 3 |
| PRKAR2A | BLOC1S1 | 0.774065 | 5 | 0 | 5 |
| PRKAR2A | OSBPL8 | 0.767 | 5 | 0 | 5 |
| PRKAR2A | HDHD2 | 0.7605 | 4 | 0 | 4 |
| PRKAR2A | ZNF70 | 0.752481 | 3 | 0 | 3 |
| PRKAR2A | GJA5 | 0.750122 | 3 | 0 | 3 |
| PRKAR2A | EEA1 | 0.743347 | 8 | 0 | 6 |
| PRKAR2A | PITHD1 | 0.741442 | 6 | 0 | 6 |
| PRKAR2A | CMPK1 | 0.740288 | 7 | 0 | 6 |
| PRKAR2A | SYPL1 | 0.739998 | 4 | 0 | 4 |
| PRKAR2A | SMDT1 | 0.739655 | 3 | 0 | 3 |
| PRKAR2A | HIBCH | 0.737286 | 4 | 0 | 4 |
| PRKAR2A | FBXO10 | 0.736491 | 4 | 0 | 4 |
| PRKAR2A | ZNF626 | 0.735365 | 5 | 0 | 5 |
| PRKAR2A | GORASP1 | 0.734 | 7 | 0 | 7 |
| PRKAR2A | MPP7 | 0.732759 | 7 | 0 | 7 |
| PRKAR2A | EIF4E3 | 0.731797 | 5 | 0 | 4 |
| PRKAR2A | ZNF823 | 0.731681 | 7 | 0 | 7 |
| PRKAR2A | ZNF33A | 0.730831 | 3 | 0 | 3 |
For details and further investigation, click here
