GYS2

 

Full name: glycogen synthase 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 12p12.1
Entrez ID: 2998 HGNC ID: HGNC:4707 Ensembl Gene: ENSG00000111713 OMIM ID: 138571
Drug and gene relationship at DGIdb

 

GYS2 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04910Insulin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance

 

Expression of GYS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GYS2 2998 214621_at -2.9272 0.0542
GSE20347 GYS2 2998 214621_at -2.9973 0.0000
GSE23400 GYS2 2998 214621_at -1.6403 0.0000
GSE26886 GYS2 2998 214621_at -4.0860 0.0000
GSE29001 GYS2 2998 214621_at -3.7801 0.0000
GSE38129 GYS2 2998 214621_at -2.7159 0.0000
GSE45670 GYS2 2998 214621_at -2.7303 0.0018
GSE53622 GYS2 2998 22906 -5.0787 0.0000
GSE53624 GYS2 2998 22906 -5.9009 0.0000
GSE63941 GYS2 2998 214621_at -0.0186 0.9095
GSE77861 GYS2 2998 214621_at -3.4740 0.0010
SRP007169 GYS2 2998 RNAseq -9.7530 0.0000
SRP008496 GYS2 2998 RNAseq -8.2436 0.0000
SRP064894 GYS2 2998 RNAseq -6.5189 0.0000
SRP133303 GYS2 2998 RNAseq -6.9596 0.0000
SRP159526 GYS2 2998 RNAseq -6.9905 0.0000
TCGA GYS2 2998 RNAseq 1.4399 0.1418

Upregulated datasets: 0; Downregulated datasets: 14.  

 

Survival by GYS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GYS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GYS2 2998 9 2 19
GSE20123 GYS2 2998 9 2 19
GSE43470 GYS2 2998 9 4 30
GSE46452 GYS2 2998 10 1 48
GSE47630 GYS2 2998 14 1 25
GSE54993 GYS2 2998 1 9 60
GSE54994 GYS2 2998 11 2 40
GSE60625 GYS2 2998 0 1 10
GSE74703 GYS2 2998 9 3 24
GSE74704 GYS2 2998 6 1 13
TCGA GYS2 2998 42 5 49

Total number of gains: 120; Total number of losses: 31; Total Number of normals: 337.  

 

Somatic mutations of GYS2:

 

Generating mutation plots.

 

Highly correlated genes for GYS2:

 

Showing top 20/1920 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GYS2SFTA20.930062404
GYS2CRISP30.91596110010
GYS2ENDOU0.90601710010
GYS2RANBP90.90295110010
GYS2EHD30.90090310010
GYS2UBL30.8980210010
GYS2ECM10.8928410010
GYS2SPNS20.892182404
GYS2FLG0.89157310010
GYS2TP53I30.89093910010
GYS2SCNN1B0.89070710010
GYS2C18orf250.88733510010
GYS2MXD10.8869410010
GYS2FNDC40.88407310010
GYS2TRIP100.8837810010
GYS2ATG9B0.883313606
GYS2SASH10.88259110010
GYS2EPB41L30.8806210010
GYS2YOD10.88031510010
GYS2SLURP10.87988510010

For details and further investigation, click here