| Full name: cysteine rich secretory protein 3 | Alias Symbol: SGP28|CRISP-3|CRS3|dJ442L6.3|Aeg2 | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 10321 | HGNC ID: HGNC:16904 | Ensembl Gene: ENSG00000096006 | OMIM ID: 618062 |
| Drug and gene relationship at DGIdb | |||
Expression of CRISP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRISP3 | 10321 | 207802_at | -6.7005 | 0.0057 | |
| GSE20347 | CRISP3 | 10321 | 207802_at | -7.1420 | 0.0000 | |
| GSE23400 | CRISP3 | 10321 | 207802_at | -5.2357 | 0.0000 | |
| GSE26886 | CRISP3 | 10321 | 207802_at | -8.4076 | 0.0000 | |
| GSE29001 | CRISP3 | 10321 | 207802_at | -7.0516 | 0.0000 | |
| GSE38129 | CRISP3 | 10321 | 207802_at | -5.8271 | 0.0000 | |
| GSE45670 | CRISP3 | 10321 | 207802_at | -4.9297 | 0.0024 | |
| GSE53622 | CRISP3 | 10321 | 60381 | -6.0310 | 0.0000 | |
| GSE53624 | CRISP3 | 10321 | 60381 | -5.6672 | 0.0000 | |
| GSE63941 | CRISP3 | 10321 | 207802_at | 0.5946 | 0.6405 | |
| GSE77861 | CRISP3 | 10321 | 207802_at | -5.0086 | 0.0029 | |
| GSE97050 | CRISP3 | 10321 | A_23_P419760 | -3.3848 | 0.1150 | |
| SRP007169 | CRISP3 | 10321 | RNAseq | -15.3182 | 0.0000 | |
| SRP008496 | CRISP3 | 10321 | RNAseq | -8.9969 | 0.0000 | |
| SRP064894 | CRISP3 | 10321 | RNAseq | -7.7640 | 0.0000 | |
| SRP133303 | CRISP3 | 10321 | RNAseq | -8.3515 | 0.0000 | |
| SRP159526 | CRISP3 | 10321 | RNAseq | -5.8242 | 0.0002 | |
| TCGA | CRISP3 | 10321 | RNAseq | -0.9307 | 0.3075 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by CRISP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRISP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRISP3 | 10321 | 5 | 2 | 23 | |
| GSE20123 | CRISP3 | 10321 | 5 | 2 | 23 | |
| GSE43470 | CRISP3 | 10321 | 5 | 0 | 38 | |
| GSE46452 | CRISP3 | 10321 | 2 | 10 | 47 | |
| GSE47630 | CRISP3 | 10321 | 7 | 5 | 28 | |
| GSE54993 | CRISP3 | 10321 | 3 | 1 | 66 | |
| GSE54994 | CRISP3 | 10321 | 8 | 4 | 41 | |
| GSE60625 | CRISP3 | 10321 | 0 | 3 | 8 | |
| GSE74703 | CRISP3 | 10321 | 5 | 0 | 31 | |
| GSE74704 | CRISP3 | 10321 | 2 | 1 | 17 | |
| TCGA | CRISP3 | 10321 | 21 | 12 | 63 |
Total number of gains: 63; Total number of losses: 40; Total Number of normals: 385.
Somatic mutations of CRISP3:
Generating mutation plots.
Highly correlated genes for CRISP3:
Showing top 20/1917 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRISP3 | KRT78 | 0.917683 | 7 | 0 | 7 |
| CRISP3 | GYS2 | 0.915961 | 10 | 0 | 10 |
| CRISP3 | ENDOU | 0.9145 | 11 | 0 | 11 |
| CRISP3 | SASH1 | 0.90674 | 11 | 0 | 11 |
| CRISP3 | CLIC3 | 0.904743 | 9 | 0 | 9 |
| CRISP3 | FAM3D | 0.902181 | 7 | 0 | 7 |
| CRISP3 | ECM1 | 0.901776 | 11 | 0 | 11 |
| CRISP3 | TGM3 | 0.890325 | 11 | 0 | 11 |
| CRISP3 | HCG22 | 0.880624 | 6 | 0 | 6 |
| CRISP3 | UBL3 | 0.878533 | 11 | 0 | 11 |
| CRISP3 | PPL | 0.877367 | 11 | 0 | 11 |
| CRISP3 | EHD3 | 0.876599 | 11 | 0 | 11 |
| CRISP3 | NUCB2 | 0.873892 | 11 | 0 | 11 |
| CRISP3 | SCNN1B | 0.873428 | 11 | 0 | 11 |
| CRISP3 | PADI1 | 0.872449 | 8 | 0 | 8 |
| CRISP3 | SPINK7 | 0.87215 | 7 | 0 | 7 |
| CRISP3 | RANBP9 | 0.872109 | 11 | 0 | 11 |
| CRISP3 | PSCA | 0.870607 | 8 | 0 | 8 |
| CRISP3 | FLG | 0.870455 | 11 | 0 | 11 |
| CRISP3 | ABLIM3 | 0.868089 | 10 | 0 | 10 |
For details and further investigation, click here
