PHACTR4

 

Full name: phosphatase and actin regulator 4 Alias Symbol: FLJ13171|PPP1R124
Type: protein-coding gene Cytoband: 1p35.3
Entrez ID: 65979 HGNC ID: HGNC:25793 Ensembl Gene: ENSG00000204138 OMIM ID: 608726
Drug and gene relationship at DGIdb

 

Expression of PHACTR4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PHACTR4 65979 226823_at -0.9413 0.1144
GSE20347 PHACTR4 65979 219235_s_at -1.3452 0.0000
GSE23400 PHACTR4 65979 219235_s_at -1.3179 0.0000
GSE26886 PHACTR4 65979 226823_at -1.7315 0.0000
GSE29001 PHACTR4 65979 219235_s_at -1.7660 0.0008
GSE38129 PHACTR4 65979 219235_s_at -1.0343 0.0000
GSE45670 PHACTR4 65979 226823_at -0.5401 0.1042
GSE53622 PHACTR4 65979 24714 -1.4270 0.0000
GSE53624 PHACTR4 65979 24714 -1.4745 0.0000
GSE63941 PHACTR4 65979 226823_at 0.4979 0.0547
GSE77861 PHACTR4 65979 226823_at -1.6389 0.0006
GSE97050 PHACTR4 65979 A_33_P3321611 -0.8562 0.1927
SRP007169 PHACTR4 65979 RNAseq -2.4565 0.0000
SRP008496 PHACTR4 65979 RNAseq -2.7715 0.0000
SRP064894 PHACTR4 65979 RNAseq -1.6950 0.0000
SRP133303 PHACTR4 65979 RNAseq -1.1666 0.0000
SRP159526 PHACTR4 65979 RNAseq -1.4292 0.0000
SRP193095 PHACTR4 65979 RNAseq -1.9631 0.0000
SRP219564 PHACTR4 65979 RNAseq -1.7122 0.0005
TCGA PHACTR4 65979 RNAseq -0.0169 0.7523

Upregulated datasets: 0; Downregulated datasets: 15.  

 

Survival by PHACTR4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PHACTR4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PHACTR4 65979 0 6 24
GSE20123 PHACTR4 65979 0 5 25
GSE43470 PHACTR4 65979 3 6 34
GSE46452 PHACTR4 65979 5 1 53
GSE47630 PHACTR4 65979 8 3 29
GSE54993 PHACTR4 65979 2 1 67
GSE54994 PHACTR4 65979 10 4 39
GSE60625 PHACTR4 65979 0 0 11
GSE74703 PHACTR4 65979 2 4 30
GSE74704 PHACTR4 65979 0 0 20
TCGA PHACTR4 65979 11 22 63

Total number of gains: 41; Total number of losses: 52; Total Number of normals: 395.  

 

Somatic mutations of PHACTR4:

 

Generating mutation plots.

 

Highly correlated genes for PHACTR4:

 

Showing top 20/1493 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PHACTR4SPNS20.883762505
PHACTR4TCP11L20.878275505
PHACTR4GYS20.86753310010
PHACTR4SFTA20.858465404
PHACTR4FAM214A0.855107606
PHACTR4KRT780.851458707
PHACTR4C5orf66-AS10.84956606
PHACTR4KLB0.84906606
PHACTR4ZNRF10.842399404
PHACTR4SPINK70.836659606
PHACTR4FAM3D0.834395707
PHACTR4SMIM50.834072606
PHACTR4RAET1E0.83197606
PHACTR4TTC90.83193311011
PHACTR4SASH10.83107611011
PHACTR4ATG9B0.830497707
PHACTR4CAPN140.828765606
PHACTR4CRISP30.82395211011
PHACTR4MAGI30.82226606
PHACTR4TMOD30.82208211011

For details and further investigation, click here