| Full name: fucosyltransferase 3 (Lewis blood group) | Alias Symbol: CD174 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 2525 | HGNC ID: HGNC:4014 | Ensembl Gene: ENSG00000171124 | OMIM ID: 111100 |
| Drug and gene relationship at DGIdb | |||
Expression of FUT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FUT3 | 2525 | 214088_s_at | -1.8708 | 0.1560 | |
| GSE20347 | FUT3 | 2525 | 214088_s_at | -2.3623 | 0.0000 | |
| GSE23400 | FUT3 | 2525 | 214088_s_at | -1.5261 | 0.0000 | |
| GSE26886 | FUT3 | 2525 | 214088_s_at | -3.7772 | 0.0000 | |
| GSE29001 | FUT3 | 2525 | 214088_s_at | -2.8146 | 0.0000 | |
| GSE38129 | FUT3 | 2525 | 214088_s_at | -1.7485 | 0.0001 | |
| GSE45670 | FUT3 | 2525 | 214088_s_at | -0.6250 | 0.1248 | |
| GSE53622 | FUT3 | 2525 | 77425 | -1.4971 | 0.0000 | |
| GSE53624 | FUT3 | 2525 | 77425 | -2.0717 | 0.0000 | |
| GSE63941 | FUT3 | 2525 | 214088_s_at | 0.9015 | 0.4188 | |
| GSE77861 | FUT3 | 2525 | 214088_s_at | -1.5201 | 0.0053 | |
| GSE97050 | FUT3 | 2525 | A_23_P360316 | -0.2167 | 0.5127 | |
| SRP007169 | FUT3 | 2525 | RNAseq | -4.1692 | 0.0000 | |
| SRP008496 | FUT3 | 2525 | RNAseq | -4.7633 | 0.0000 | |
| SRP064894 | FUT3 | 2525 | RNAseq | -3.2289 | 0.0000 | |
| SRP133303 | FUT3 | 2525 | RNAseq | -2.6040 | 0.0000 | |
| SRP159526 | FUT3 | 2525 | RNAseq | -4.6756 | 0.0000 | |
| SRP193095 | FUT3 | 2525 | RNAseq | -2.9267 | 0.0000 | |
| SRP219564 | FUT3 | 2525 | RNAseq | -3.6356 | 0.0006 | |
| TCGA | FUT3 | 2525 | RNAseq | -0.1068 | 0.7361 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by FUT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FUT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FUT3 | 2525 | 5 | 3 | 22 | |
| GSE20123 | FUT3 | 2525 | 4 | 2 | 24 | |
| GSE43470 | FUT3 | 2525 | 2 | 6 | 35 | |
| GSE46452 | FUT3 | 2525 | 47 | 1 | 11 | |
| GSE47630 | FUT3 | 2525 | 5 | 7 | 28 | |
| GSE54993 | FUT3 | 2525 | 16 | 3 | 51 | |
| GSE54994 | FUT3 | 2525 | 6 | 16 | 31 | |
| GSE60625 | FUT3 | 2525 | 9 | 0 | 2 | |
| GSE74703 | FUT3 | 2525 | 2 | 4 | 30 | |
| GSE74704 | FUT3 | 2525 | 1 | 2 | 17 | |
| TCGA | FUT3 | 2525 | 10 | 18 | 68 |
Total number of gains: 107; Total number of losses: 62; Total Number of normals: 319.
Somatic mutations of FUT3:
Generating mutation plots.
Highly correlated genes for FUT3:
Showing top 20/1758 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FUT3 | EPS8L1 | 0.869861 | 13 | 0 | 13 |
| FUT3 | C5orf66-AS1 | 0.864044 | 6 | 0 | 6 |
| FUT3 | PADI1 | 0.862136 | 8 | 0 | 8 |
| FUT3 | SCNN1B | 0.858918 | 12 | 0 | 12 |
| FUT3 | CYSRT1 | 0.853539 | 7 | 0 | 7 |
| FUT3 | TTC9 | 0.853353 | 13 | 0 | 12 |
| FUT3 | CLIC3 | 0.85065 | 10 | 0 | 10 |
| FUT3 | ACPP | 0.847566 | 12 | 0 | 12 |
| FUT3 | CEACAM6 | 0.844072 | 13 | 0 | 13 |
| FUT3 | EVPL | 0.836999 | 12 | 0 | 11 |
| FUT3 | FAM3D | 0.836851 | 9 | 0 | 9 |
| FUT3 | SMAGP | 0.835916 | 12 | 0 | 12 |
| FUT3 | UPK3B | 0.835677 | 3 | 0 | 3 |
| FUT3 | CLCA4 | 0.834689 | 12 | 0 | 12 |
| FUT3 | CEACAM5 | 0.83324 | 13 | 0 | 13 |
| FUT3 | FBXO34 | 0.833142 | 10 | 0 | 10 |
| FUT3 | GDPD3 | 0.830865 | 13 | 0 | 12 |
| FUT3 | ATP13A4 | 0.829179 | 8 | 0 | 8 |
| FUT3 | KLB | 0.82851 | 6 | 0 | 6 |
| FUT3 | NIPAL1 | 0.826233 | 3 | 0 | 3 |
For details and further investigation, click here
