CBLB

 

Full name: Cbl proto-oncogene B Alias Symbol: RNF56|Cbl-b
Type: protein-coding gene Cytoband: 3q13.11
Entrez ID: 868 HGNC ID: HGNC:1542 Ensembl Gene: ENSG00000114423 OMIM ID: 604491
Drug and gene relationship at DGIdb

 

CBLB involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04660T cell receptor signaling pathway
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05162Measles
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05220Chronic myeloid leukemia

 

Expression of CBLB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CBLB 868 209682_at 0.7723 0.0618
GSE20347 CBLB 868 209682_at 1.3179 0.0000
GSE23400 CBLB 868 209682_at 1.1014 0.0000
GSE26886 CBLB 868 209682_at 2.3504 0.0000
GSE29001 CBLB 868 209682_at 1.3437 0.0002
GSE38129 CBLB 868 209682_at 0.7965 0.0004
GSE45670 CBLB 868 209682_at 0.3543 0.3348
GSE53622 CBLB 868 68614 0.8371 0.0000
GSE53624 CBLB 868 106282 1.1212 0.0000
GSE63941 CBLB 868 209682_at -1.1121 0.1536
GSE77861 CBLB 868 209682_at 1.4841 0.0031
GSE97050 CBLB 868 A_23_P29830 0.8745 0.0828
SRP007169 CBLB 868 RNAseq 1.5117 0.0000
SRP008496 CBLB 868 RNAseq 1.8138 0.0000
SRP064894 CBLB 868 RNAseq 0.7758 0.0033
SRP133303 CBLB 868 RNAseq 0.5118 0.0005
SRP159526 CBLB 868 RNAseq 0.3622 0.1208
SRP193095 CBLB 868 RNAseq 1.0001 0.0001
SRP219564 CBLB 868 RNAseq 0.7492 0.0030
TCGA CBLB 868 RNAseq 0.0500 0.4963

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by CBLB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CBLB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CBLB 868 17 1 12
GSE20123 CBLB 868 16 1 13
GSE43470 CBLB 868 17 1 25
GSE46452 CBLB 868 12 6 41
GSE47630 CBLB 868 16 6 18
GSE54993 CBLB 868 2 5 63
GSE54994 CBLB 868 28 5 20
GSE60625 CBLB 868 0 6 5
GSE74703 CBLB 868 14 1 21
GSE74704 CBLB 868 12 2 6
TCGA CBLB 868 49 8 39

Total number of gains: 183; Total number of losses: 42; Total Number of normals: 263.  

 

Somatic mutations of CBLB:

 

Generating mutation plots.

 

Highly correlated genes for CBLB:

 

Showing top 20/1740 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CBLBZC3HC10.87971303
CBLBTMTC40.824945303
CBLBZNF6280.816945303
CBLBPKN30.815692303
CBLBPKIG0.805829303
CBLBTMEM63B0.780578303
CBLBPTPRK0.76914410010
CBLBGNG100.769034303
CBLBKIAA01000.763963303
CBLBDDX540.760027404
CBLBSSBP40.759581505
CBLBTMED80.757335505
CBLBZNF5790.754844303
CBLBWDR810.753472404
CBLBSLC39A30.751673403
CBLBTP53I130.748267504
CBLBPDE7A0.746041606
CBLBZNF5740.737072303
CBLBMRPS50.734847303
CBLBSLC39A140.73333410010

For details and further investigation, click here