DDX58

 

Full name: DExD/H-box helicase 58 Alias Symbol: RIG-I|FLJ13599|DKFZp434J1111|RIG-1|RIG1
Type: protein-coding gene Cytoband: 9p21.1
Entrez ID: 23586 HGNC ID: HGNC:19102 Ensembl Gene: ENSG00000107201 OMIM ID: 609631
Drug and gene relationship at DGIdb

 

DDX58 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of DDX58:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DDX58 23586 218943_s_at 0.0247 0.9843
GSE20347 DDX58 23586 218943_s_at 0.4765 0.1239
GSE23400 DDX58 23586 218943_s_at 0.6221 0.0000
GSE26886 DDX58 23586 242961_x_at 0.1113 0.8074
GSE29001 DDX58 23586 218943_s_at 0.5721 0.1878
GSE38129 DDX58 23586 218943_s_at 0.5138 0.0378
GSE45670 DDX58 23586 242961_x_at 0.4208 0.3252
GSE53622 DDX58 23586 26388 0.5700 0.0000
GSE53624 DDX58 23586 26388 0.9742 0.0000
GSE63941 DDX58 23586 218943_s_at -0.4741 0.7384
GSE77861 DDX58 23586 242961_x_at 0.7879 0.1863
GSE97050 DDX58 23586 A_33_P3372910 -0.1282 0.6523
SRP007169 DDX58 23586 RNAseq 1.0280 0.1597
SRP008496 DDX58 23586 RNAseq 0.8723 0.0586
SRP064894 DDX58 23586 RNAseq 1.1768 0.0000
SRP133303 DDX58 23586 RNAseq 0.5038 0.0197
SRP159526 DDX58 23586 RNAseq -0.6368 0.0712
SRP193095 DDX58 23586 RNAseq 0.6375 0.0006
SRP219564 DDX58 23586 RNAseq 0.0201 0.9714
TCGA DDX58 23586 RNAseq 0.2463 0.0110

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DDX58 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DDX58:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DDX58 23586 2 15 13
GSE20123 DDX58 23586 2 15 13
GSE43470 DDX58 23586 4 10 29
GSE46452 DDX58 23586 6 17 36
GSE47630 DDX58 23586 1 21 18
GSE54993 DDX58 23586 6 0 64
GSE54994 DDX58 23586 7 11 35
GSE60625 DDX58 23586 0 0 11
GSE74703 DDX58 23586 3 7 26
GSE74704 DDX58 23586 0 11 9
TCGA DDX58 23586 16 45 35

Total number of gains: 47; Total number of losses: 152; Total Number of normals: 289.  

 

Somatic mutations of DDX58:

 

Generating mutation plots.

 

Highly correlated genes for DDX58:

 

Showing top 20/180 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DDX58ME20.713965303
DDX58ZSCAN300.691334303
DDX58KLRC40.675505303
DDX58IFI44L0.67108811010
DDX58ZNF8140.669777403
DDX58RSAD20.66901912011
DDX58IFIT10.66103612010
DDX58TBRG10.660069303
DDX58MTX20.658171404
DDX58DDX600.65265912011
DDX58SP1000.6470891008
DDX58IFI440.64381312011
DDX58SRSF110.643013303
DDX58PARP90.635984706
DDX58NBEAL10.633526303
DDX58NAPB0.63204303
DDX58ARHGAP90.630712303
DDX58XAF10.6296561009
DDX58CEBPZ0.628835403
DDX58IFI60.62170111010

For details and further investigation, click here