| Full name: XIAP associated factor 1 | Alias Symbol: BIRC4BP|XIAPAF1|HSXIAPAF1 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 54739 | HGNC ID: HGNC:30932 | Ensembl Gene: ENSG00000132530 | OMIM ID: 606717 |
| Drug and gene relationship at DGIdb | |||
Expression of XAF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XAF1 | 54739 | 228617_at | 0.1820 | 0.9155 | |
| GSE20347 | XAF1 | 54739 | 206133_at | 0.7448 | 0.0031 | |
| GSE23400 | XAF1 | 54739 | 206133_at | 0.6917 | 0.0000 | |
| GSE26886 | XAF1 | 54739 | 228617_at | 1.5015 | 0.0131 | |
| GSE29001 | XAF1 | 54739 | 206133_at | 1.6617 | 0.0121 | |
| GSE38129 | XAF1 | 54739 | 206133_at | 0.6922 | 0.0095 | |
| GSE45670 | XAF1 | 54739 | 228617_at | 1.7179 | 0.0001 | |
| GSE53622 | XAF1 | 54739 | 159665 | 1.0067 | 0.0000 | |
| GSE53624 | XAF1 | 54739 | 159665 | 0.9979 | 0.0000 | |
| GSE63941 | XAF1 | 54739 | 206133_at | -3.1376 | 0.0144 | |
| GSE77861 | XAF1 | 54739 | 228617_at | 0.1787 | 0.7734 | |
| GSE97050 | XAF1 | 54739 | A_33_P3258346 | 0.8020 | 0.1819 | |
| SRP007169 | XAF1 | 54739 | RNAseq | 1.5121 | 0.0019 | |
| SRP008496 | XAF1 | 54739 | RNAseq | 1.3265 | 0.0007 | |
| SRP064894 | XAF1 | 54739 | RNAseq | 1.8534 | 0.0000 | |
| SRP133303 | XAF1 | 54739 | RNAseq | 0.4509 | 0.0076 | |
| SRP159526 | XAF1 | 54739 | RNAseq | -0.3187 | 0.5958 | |
| SRP193095 | XAF1 | 54739 | RNAseq | 0.7420 | 0.0000 | |
| SRP219564 | XAF1 | 54739 | RNAseq | 1.0319 | 0.0790 | |
| TCGA | XAF1 | 54739 | RNAseq | 0.3460 | 0.0054 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by XAF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XAF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XAF1 | 54739 | 4 | 2 | 24 | |
| GSE20123 | XAF1 | 54739 | 4 | 3 | 23 | |
| GSE43470 | XAF1 | 54739 | 1 | 6 | 36 | |
| GSE46452 | XAF1 | 54739 | 34 | 1 | 24 | |
| GSE47630 | XAF1 | 54739 | 7 | 1 | 32 | |
| GSE54993 | XAF1 | 54739 | 4 | 3 | 63 | |
| GSE54994 | XAF1 | 54739 | 5 | 8 | 40 | |
| GSE60625 | XAF1 | 54739 | 4 | 0 | 7 | |
| GSE74703 | XAF1 | 54739 | 1 | 3 | 32 | |
| GSE74704 | XAF1 | 54739 | 2 | 1 | 17 | |
| TCGA | XAF1 | 54739 | 19 | 20 | 57 |
Total number of gains: 85; Total number of losses: 48; Total Number of normals: 355.
Somatic mutations of XAF1:
Generating mutation plots.
Highly correlated genes for XAF1:
Showing top 20/431 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XAF1 | USP41 | 0.793608 | 3 | 0 | 3 |
| XAF1 | IFI44 | 0.784144 | 13 | 0 | 13 |
| XAF1 | IFI6 | 0.777301 | 12 | 0 | 12 |
| XAF1 | CMPK2 | 0.775375 | 8 | 0 | 7 |
| XAF1 | DDX60 | 0.757816 | 13 | 0 | 13 |
| XAF1 | IFIT1 | 0.754055 | 13 | 0 | 13 |
| XAF1 | IFI44L | 0.752775 | 13 | 0 | 12 |
| XAF1 | IFIT3 | 0.743857 | 13 | 0 | 13 |
| XAF1 | STAT1 | 0.74269 | 13 | 0 | 13 |
| XAF1 | EPSTI1 | 0.739684 | 9 | 0 | 8 |
| XAF1 | MX1 | 0.725652 | 11 | 0 | 10 |
| XAF1 | DTX3L | 0.724958 | 7 | 0 | 6 |
| XAF1 | RSAD2 | 0.72416 | 13 | 0 | 12 |
| XAF1 | IRF9 | 0.722732 | 8 | 0 | 8 |
| XAF1 | PRPF4B | 0.716089 | 3 | 0 | 3 |
| XAF1 | SP110 | 0.712047 | 13 | 0 | 12 |
| XAF1 | HERC5 | 0.711639 | 12 | 0 | 12 |
| XAF1 | IFI35 | 0.711476 | 12 | 0 | 12 |
| XAF1 | DDX60L | 0.71039 | 7 | 0 | 5 |
| XAF1 | UBE2L6 | 0.707655 | 12 | 0 | 11 |
For details and further investigation, click here
