| Full name: malic enzyme 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.2 | ||
| Entrez ID: 4200 | HGNC ID: HGNC:6984 | Ensembl Gene: ENSG00000082212 | OMIM ID: 154270 |
| Drug and gene relationship at DGIdb | |||
Expression of ME2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ME2 | 4200 | 209397_at | -0.1198 | 0.9105 | |
| GSE20347 | ME2 | 4200 | 209397_at | 0.2939 | 0.1302 | |
| GSE23400 | ME2 | 4200 | 209397_at | 0.1751 | 0.0627 | |
| GSE26886 | ME2 | 4200 | 209397_at | 0.6007 | 0.0143 | |
| GSE29001 | ME2 | 4200 | 209397_at | 0.0495 | 0.8846 | |
| GSE38129 | ME2 | 4200 | 209397_at | 0.1542 | 0.3461 | |
| GSE45670 | ME2 | 4200 | 209397_at | 0.0166 | 0.9503 | |
| GSE53622 | ME2 | 4200 | 55164 | 0.1489 | 0.1346 | |
| GSE53624 | ME2 | 4200 | 55164 | 0.1941 | 0.0441 | |
| GSE63941 | ME2 | 4200 | 209397_at | -0.2571 | 0.6050 | |
| GSE77861 | ME2 | 4200 | 209397_at | 0.4017 | 0.1375 | |
| GSE97050 | ME2 | 4200 | A_23_P321261 | -0.0428 | 0.9141 | |
| SRP007169 | ME2 | 4200 | RNAseq | 0.6575 | 0.0699 | |
| SRP008496 | ME2 | 4200 | RNAseq | 0.8954 | 0.0041 | |
| SRP064894 | ME2 | 4200 | RNAseq | 0.1660 | 0.4359 | |
| SRP133303 | ME2 | 4200 | RNAseq | 0.1937 | 0.2283 | |
| SRP159526 | ME2 | 4200 | RNAseq | 0.3352 | 0.3992 | |
| SRP193095 | ME2 | 4200 | RNAseq | -0.0091 | 0.9638 | |
| SRP219564 | ME2 | 4200 | RNAseq | -0.2972 | 0.4713 | |
| TCGA | ME2 | 4200 | RNAseq | -0.2612 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ME2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ME2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ME2 | 4200 | 1 | 9 | 20 | |
| GSE20123 | ME2 | 4200 | 1 | 9 | 20 | |
| GSE43470 | ME2 | 4200 | 0 | 4 | 39 | |
| GSE46452 | ME2 | 4200 | 1 | 26 | 32 | |
| GSE47630 | ME2 | 4200 | 5 | 20 | 15 | |
| GSE54993 | ME2 | 4200 | 9 | 0 | 61 | |
| GSE54994 | ME2 | 4200 | 1 | 17 | 35 | |
| GSE60625 | ME2 | 4200 | 0 | 4 | 7 | |
| GSE74703 | ME2 | 4200 | 0 | 4 | 32 | |
| GSE74704 | ME2 | 4200 | 1 | 6 | 13 | |
| TCGA | ME2 | 4200 | 8 | 45 | 43 |
Total number of gains: 27; Total number of losses: 144; Total Number of normals: 317.
Somatic mutations of ME2:
Generating mutation plots.
Highly correlated genes for ME2:
Showing top 20/481 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ME2 | MRPL9 | 0.766396 | 3 | 0 | 3 |
| ME2 | CACNA2D4 | 0.754333 | 3 | 0 | 3 |
| ME2 | NAPB | 0.721797 | 3 | 0 | 3 |
| ME2 | DDX58 | 0.713965 | 3 | 0 | 3 |
| ME2 | FANCL | 0.710532 | 3 | 0 | 3 |
| ME2 | HDHD2 | 0.707241 | 3 | 0 | 3 |
| ME2 | ACBD6 | 0.702374 | 3 | 0 | 3 |
| ME2 | CBX5 | 0.692605 | 3 | 0 | 3 |
| ME2 | METTL23 | 0.69189 | 4 | 0 | 4 |
| ME2 | DEGS1 | 0.690952 | 3 | 0 | 3 |
| ME2 | ZCCHC7 | 0.69039 | 5 | 0 | 4 |
| ME2 | ZNF397 | 0.688524 | 4 | 0 | 3 |
| ME2 | RNF13 | 0.685216 | 4 | 0 | 3 |
| ME2 | CORO2B | 0.683144 | 3 | 0 | 3 |
| ME2 | MAK16 | 0.683006 | 4 | 0 | 3 |
| ME2 | UXS1 | 0.682011 | 4 | 0 | 3 |
| ME2 | RCN2 | 0.676064 | 5 | 0 | 4 |
| ME2 | PCGF6 | 0.675955 | 4 | 0 | 3 |
| ME2 | DBF4 | 0.67543 | 4 | 0 | 3 |
| ME2 | MED30 | 0.67445 | 4 | 0 | 4 |
For details and further investigation, click here
