IFIT1

 

Full name: interferon induced protein with tetratricopeptide repeats 1 Alias Symbol: GARG-16
Type: protein-coding gene Cytoband: 10q23.31
Entrez ID: 3434 HGNC ID: HGNC:5407 Ensembl Gene: ENSG00000185745 OMIM ID: 147690
Drug and gene relationship at DGIdb

 

IFIT1 involved pathways:

KEGG pathway Description View
hsa05160Hepatitis C

 

Expression of IFIT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFIT1 3434 203153_at 0.3377 0.8749
GSE20347 IFIT1 3434 203153_at 1.6655 0.0024
GSE23400 IFIT1 3434 203153_at 1.0922 0.0000
GSE26886 IFIT1 3434 203153_at 1.3192 0.0424
GSE29001 IFIT1 3434 203153_at 2.3605 0.0010
GSE38129 IFIT1 3434 203153_at 1.0424 0.0244
GSE45670 IFIT1 3434 203153_at 1.9843 0.0028
GSE53622 IFIT1 3434 63996 0.8883 0.0002
GSE53624 IFIT1 3434 63996 1.7141 0.0000
GSE63941 IFIT1 3434 203153_at -1.2268 0.4815
GSE77861 IFIT1 3434 203153_at 0.5435 0.3441
GSE97050 IFIT1 3434 A_23_P52266 0.0422 0.9304
SRP007169 IFIT1 3434 RNAseq 2.3683 0.0000
SRP008496 IFIT1 3434 RNAseq 2.6595 0.0000
SRP064894 IFIT1 3434 RNAseq 2.6184 0.0000
SRP133303 IFIT1 3434 RNAseq 0.8805 0.0067
SRP159526 IFIT1 3434 RNAseq -0.4120 0.6181
SRP193095 IFIT1 3434 RNAseq 1.9322 0.0000
SRP219564 IFIT1 3434 RNAseq 0.6910 0.4559
TCGA IFIT1 3434 RNAseq 0.7454 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by IFIT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFIT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFIT1 3434 2 7 21
GSE20123 IFIT1 3434 2 6 22
GSE43470 IFIT1 3434 0 8 35
GSE46452 IFIT1 3434 0 11 48
GSE47630 IFIT1 3434 2 14 24
GSE54993 IFIT1 3434 7 0 63
GSE54994 IFIT1 3434 1 11 41
GSE60625 IFIT1 3434 0 0 11
GSE74703 IFIT1 3434 0 6 30
GSE74704 IFIT1 3434 1 4 15
TCGA IFIT1 3434 7 27 62

Total number of gains: 22; Total number of losses: 94; Total Number of normals: 372.  

 

Somatic mutations of IFIT1:

 

Generating mutation plots.

 

Highly correlated genes for IFIT1:

 

Showing top 20/424 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFIT1IFI44L0.85324513013
IFIT1IFI440.83905913013
IFIT1IFIT30.83110913012
IFIT1IFI60.82050213013
IFIT1RSAD20.81351713013
IFIT1DDX600.80820113013
IFIT1ISG150.79366512012
IFIT1MX10.77951212012
IFIT1IFI350.76365513013
IFIT1HERC50.76142813012
IFIT1XAF10.75405513013
IFIT1CMPK20.753656907
IFIT1RBM390.749003303
IFIT1EPSTI10.741972808
IFIT1IFITM10.740317909
IFIT1IFIH10.73368411010
IFIT1DDX60L0.730375707
IFIT1IFIT50.72864413012
IFIT1USP410.72567303
IFIT1SP1000.72431213012

For details and further investigation, click here